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The Time Course of Cognitive Deficits in Experimental Subarachnoid Hemorrhage

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Subarachnoid Hemorrhage

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 127))

Abstract

Subarachnoid hemorrhage (SAH) is a devastating stroke type. Approximately 50% of survivors suffer from the permanent disability, caused by the cognitive deficits. To enrich the pre-clinical research on the neurological deficits after SAH, we investigate the temporal cognitive deficits and the longitudinal course of cognitive recovery in endovascular perforation SAH murine model. The SAH mice show reproducible body weakness and headache-symbolized moaning symptoms, which is closed to clinical patients. SAH mice exhibit significantly impaired cognitive function in domains of learning ability, short-term and long-term memory. The cognitive deficits occur mostly in the early phase and recover gradually till day 10 after SAH. The systematical assessments of cognitive function after experimental aneurysmal SAH elucidate the time course of cognitive deficits and provide the time window of potential interventions.

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Acknowledgments

The authors appreciate the help and support from the colleagues of the Department of Surgery, The Chinese University of Hong Kong.

Conflict of Interest Statement: The authors declared no financial or intellectual conflict of interest.

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Authors and Affiliations

  1. Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China

    Zhiyuan Vera Zheng, Wai Sang Poon & Kwok Chu George Wong

  2. Department of Surgery, Chow Tai Fook-Cheng Yu Tung Surgical Stem cell Research Centre, The Chinese University of Hong Kong, Hong Kong, China

    Ping Kuen Lam

Authors
  1. Zhiyuan Vera Zheng
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  2. Ping Kuen Lam
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  3. Wai Sang Poon
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  4. Kwok Chu George Wong
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Corresponding author

Correspondence to Kwok Chu George Wong .

Editor information

Editors and Affiliations

  1. Department of Anethesiology, Loma Linda University Medical Center, Loma Linda, CA, USA

    Robert D. Martin

  2. Department of Neurosurgery, Loma Linda University Medical Center, Loma Linda, CA, USA

    Warren Boling

  3. Department of Neurosurgery, First Affiliated Hospital of Soochow University, Suzhou, China

    Gang Chen

  4. Department of Anesthesiology and Physiology, Loma Linda University Medical Center, Loma Linda, CA, USA

    John H. Zhang

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Zheng, Z.V., Lam, P.K., Poon, W.S., Wong, K.C.G. (2020). The Time Course of Cognitive Deficits in Experimental Subarachnoid Hemorrhage. In: Martin, R., Boling, W., Chen, G., Zhang, J. (eds) Subarachnoid Hemorrhage. Acta Neurochirurgica Supplement, vol 127. Springer, Cham. https://doi.org/10.1007/978-3-030-04615-6_18

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  • DOI: https://doi.org/10.1007/978-3-030-04615-6_18

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-04614-9

  • Online ISBN: 978-3-030-04615-6

  • eBook Packages: MedicineMedicine (R0)

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