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Subarachnoid Hemorrhage Pattern Predicts Acute Cerebral Blood Flow Response in the Rat

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Subarachnoid Hemorrhage

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 127))

Abstract

There is considerable variability in the presentation of patients with acute subarachnoid hemorrhage (aSAH). Evidence suggests that a thick, diffuse clot better predicts the development of delayed cerebral ischemia and poor outcomes. In a rodent model of acute SAH, we directly measured the effects of the volume of blood injected versus the pattern of distribution of hemorrhage in the subarachnoid space on markers of early brain injury, namely, cerebral blood flow (CBF), cerebrospinal fluid (CSF) concentrations of P450 eicosanoids and catecholamines, and cortical spreading depolarizations (CSDs). There is a significant decrease in CBF, an increase in CSF biomarkers, and a trend toward increasing frequency and severity of CSDs when grouped by severity of hemorrhage but not by volume of blood injected. In severe hemorrhage grade animals, there was a progressive decrease in CBF after successive CSD events. These results suggest that the pattern of SAH (thick diffuse clots) correlates with the “clinical” severity of SAH.

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Acknowledgments

This work was supported by the Veterans Administration Merit # 5I01 BX001659-03 from the US Department of Veterans Affairs.

Conflict of Interest: The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, USA

    Jesse J. Liu, Jeffrey S. Raskin, Ravi Samatham & Justin S. Cetas

  2. Portland VA Medical Center, Portland, OR, USA

    Robin McFarlane & Justin S. Cetas

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  1. Jesse J. Liu
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  2. Jeffrey S. Raskin
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  3. Robin McFarlane
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  4. Ravi Samatham
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  5. Justin S. Cetas
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Corresponding author

Correspondence to Justin S. Cetas .

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Editors and Affiliations

  1. Department of Anethesiology, Loma Linda University Medical Center, Loma Linda, CA, USA

    Robert D. Martin

  2. Department of Neurosurgery, Loma Linda University Medical Center, Loma Linda, CA, USA

    Warren Boling

  3. Department of Neurosurgery, First Affiliated Hospital of Soochow University, Suzhou, China

    Gang Chen

  4. Department of Anesthesiology and Physiology, Loma Linda University Medical Center, Loma Linda, CA, USA

    John H. Zhang

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Liu, J.J., Raskin, J.S., McFarlane, R., Samatham, R., Cetas, J.S. (2020). Subarachnoid Hemorrhage Pattern Predicts Acute Cerebral Blood Flow Response in the Rat. In: Martin, R., Boling, W., Chen, G., Zhang, J. (eds) Subarachnoid Hemorrhage. Acta Neurochirurgica Supplement, vol 127. Springer, Cham. https://doi.org/10.1007/978-3-030-04615-6_14

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  • DOI: https://doi.org/10.1007/978-3-030-04615-6_14

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-04614-9

  • Online ISBN: 978-3-030-04615-6

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