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Opioid Metabolism, Variability, and Overdose Management in Pediatric Airway Patients

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Anesthetic Management for the Pediatric Airway

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Abstract

The use of opioids for perioperative pain management in children with pediatric airway and tonsillectomy procedures results in clinical challenges because of reported postoperative deaths and life-threatening respiratory depression. This is especially a major concern in children with significant obstructive sleep apnea. This chapter reviews opioid metabolism, genetic factors that affect opioid metabolism, adverse postoperative outcomes, and management of opioid overdose in children undergoing airway procedures.

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Author information

Authors and Affiliations

  1. Anesthesia and Pain Medicine, Children’s National Medical Center, George Washington University, Washington, DC, USA

    Sean-Patrick Alexander

  2. Department of Anesthesia, Riley Hospital for Children at Indiana University Health, Indianapolis, IN, USA

    Senthil Packiasabapathy & Senthilkumar Sadhasivam

Authors
  1. Sean-Patrick Alexander
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  2. Senthil Packiasabapathy
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  3. Senthilkumar Sadhasivam
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Corresponding author

Correspondence to Senthilkumar Sadhasivam .

Editor information

Editors and Affiliations

  1. School of Medicine, George Washington University School of Medicine, Washington, DC, USA

    Diego Preciado

  2. Department of Anesthesiology, Children’s National Health System, Washington, DC, USA

    Susan Verghese

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Alexander, SP., Packiasabapathy, S., Sadhasivam, S. (2019). Opioid Metabolism, Variability, and Overdose Management in Pediatric Airway Patients. In: Preciado, D., Verghese, S. (eds) Anesthetic Management for the Pediatric Airway . Springer, Cham. https://doi.org/10.1007/978-3-030-04600-2_17

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  • DOI: https://doi.org/10.1007/978-3-030-04600-2_17

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-04599-9

  • Online ISBN: 978-3-030-04600-2

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