Abstract
Connective tissue disorders describe diseases affecting the fascia and are now understood to encompass both genetic and autoimmune causes. Although the diseases have divergent mechanisms, the term is still commonly used and found in the name of some diseases such as “mixed connective tissue disorder.” Of the genetic disorders such as Marfan syndrome or Loeys-Dietz syndrome, some of the causative genes have been identified and mechanisms well explored. Other disorders such as fibromuscular dysplasia remain important clinically without clearly known genetic mechanisms. Depending on the mode of inheritance, each one of the genetic diseases has different proportion of women affected. Connective tissue disorders with autoimmune etiologies, i.e. autoimmune diseases, are common affecting millions of people within the United States and known to injure most organs in the body ranging from skin to kidney to heart to nervous system.
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References
Fairweather D, Rose NR. Women and autoimmune diseases. Emerg Infect Dis. 2004;10(11):2005–11.
Whitacre CC. Sex differences in autoimmune disease. Nat Immunol. 2001;2(9):777–80.
Eidinger D, Garrett TJ. Studies of the regulatory effects of the sex hormones on antibody formation and stem cell differentiation. J Exp Med. 1972;136(5):1098–116.
Fairweather D, Frisancho-Kiss S, Rose NR. Sex differences in autoimmune disease from a pathological perspective. Am J Pathol. 2008;173(3):600–9.
Kim S, Liva SM, Dalal MA, Verity MA, Voskuhl RR. Estriol ameliorates autoimmune demyelinating disease: implications for multiple sclerosis. Neurology. 1999;52(6):1230–8.
Langer-Gould A. Sex hormones and multiple sclerosis: another informative failure. Lancet Neurol. 2016;15(1):22–3.
Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997;40(9):1725.
D’Cruz DP, Khamashta MA, Hughes GRV. Systemic lupus erythematosus. Lancet. 2007;369(9561):587–96.
Johnson RT, Richardson EP. The neurological manifestations of systemic lupus erythematosus. Medicine (Baltimore). 1968;47(4):337–69.
Unterman A, Nolte JES, Boaz M, Abady M, Shoenfeld Y, Zandman-Goddard G. Neuropsychiatric syndromes in systemic lupus erythematosus: a meta-analysis. Semin Arthritis Rheum. 2011;41(1):1–11.
Mitsikostas DD, Sfikakis PP, Goadsby PJ. A meta-analysis for headache in systemic lupus erythematosus: the evidence and the myth. Brain J Neurol. 2004;127(Pt 5):1200–9.
Palagini L, Mosca M, Tani C, Gemignani A, Mauri M, Bombardieri S. Depression and systemic lupus erythematosus: a systematic review. Lupus. 2013;22(5):409–16.
al CR et. Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000... – PubMed – NCBI [Internet]. [cited 2018 Feb 19]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/14530779.
Schoenfeld SR, Kasturi S, Costenbader KH. The epidemiology of atherosclerotic cardiovascular disease among patients with SLE: a systematic review. Semin Arthritis Rheum. 2013;43(1):77–95.
Appenzeller S, Cendes F, Costallat LTL. Epileptic seizures in systemic lupus erythematosus. Neurology. 2004;63(10):1808–12.
Brandt JE, Priori R, Valesini G, Fairweather D. Sex differences in Sjögren’s syndrome: a comprehensive review of immune mechanisms. Biol Sex Differ. 2015;6:19.
Bhattacharyya S, Helfgott SM. Neurologic complications of systemic lupus erythematosus, sjögren syndrome, and rheumatoid arthritis. Semin Neurol. 2014;34(4):425–36.
Horvath IF, Szodoray P, Zeher M. Primary Sjögren’s syndrome in men: clinical and immunological characteristic based on a large cohort of Hungarian patients. Clin Rheumatol. 2008;27(12):1479–83.
Ramos-Casals M, Solans R, Rosas J, Camps MT, Gil A, Del Pino-Montes J, et al. Primary Sjögren syndrome in Spain: clinical and immunologic expression in 1010 patients. Medicine (Baltimore). 2008;87(4):210–9.
Kassan SS, Moutsopoulos HM. Clinical manifestations and early diagnosis of sjögren syndrome. Arch Intern Med. 2004;164(12):1275–84.
Delalande S, de Seze J, Fauchais A-L, Hachulla E, Stojkovic T, Ferriby D, et al. Neurologic manifestations in primary Sjögren syndrome: a study of 82 patients. Medicine (Baltimore). 2004;83(5):280–91.
Chai J, Logigian EL. Neurological manifestations of primary Sjogren’s syndrome. Curr Opin Neurol. 2010;23(5):509–13.
Mori K, Iijima M, Koike H, Hattori N, Tanaka F, Watanabe H, et al. The wide spectrum of clinical manifestations in Sjögren’s syndrome-associated neuropathy. Brain J Neurol. 2005;128(Pt 11):2518–34.
Gupta S, Gupta N. Sjögren syndrome and pregnancy: a literature review. Perm J. 2017;21:16–47.
De Carolis S, Salvi S, Botta A, Garofalo S, Garufi C, Ferrazzani S, et al. The impact of primary Sjogren’s syndrome on pregnancy outcome: our series and review of the literature. Autoimmun Rev. 2014;13(2):103–7.
Sharma AM, Kline B. The United States registry for fibromuscular dysplasia: new findings and breaking myths. Tech Vasc Interv Radiol. 2014;17(4):258–63.
Olin JW, Gornik HL, Bacharach JM, Biller J, Fine LJ, Gray BH, et al. Fibromuscular dysplasia: state of the science and critical unanswered questions: a scientific statement from the American Heart Association. Circulation. 2014;129(9):1048–78.
Plouin P-F, Perdu J, La Batide-Alanore A, Boutouyrie P, Gimenez-Roqueplo A-P, Jeunemaitre X. Fibromuscular dysplasia. Orphanet J Rare Dis. 2007;2:28.
Olin JW, Sealove BA. Diagnosis, management, and future developments of fibromuscular dysplasia. J Vasc Surg. 2011;53(3):826–836.e1.
Rushton AR. The genetics of fibromuscular dysplasia. Arch Intern Med. 1980;140:233–6.
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Ryan, S.L., Bhattacharyya, S., O’Neal, M.A. (2019). Connective Tissue Disorders in Women. In: O’Neal, M. (eds) Neurology and Psychiatry of Women. Springer, Cham. https://doi.org/10.1007/978-3-030-04245-5_2
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