Skip to main content

When on ECMO: Awaken, Extubate and Mobilize

  • Chapter
  • First Online:
Difficult Decisions in Cardiothoracic Critical Care Surgery

Abstract

Background: The use of extracorporeal membrane oxygenation (ECMO) has increased significantly to support cardio-respiratory failure patients. The ECMO utilization has worsened immobility for the critically ill patients.

Objective: To evaluate the evidence for the effects of early mobilization in cardiothoracic surgery patients receiving ECMO on feasibility and safety, duration of ECMO utilization as well as ICU and hospital length of stay.

Methods: Using a combination of MeSH terms: “early mobilization” and “ECMO”, Medline: Ovid, Embase, Scopus and CINAHL databases were searched. Studies were evaluated to determine fit to the inclusion criteria. Considering the limited amount of high quality evidence found, the inclusion criteria were expanded to include studies evaluating sedation interruption, extubation and early mobilization in intensive care unit patients with/without ECMO.

Results: Eighteen studies were selected. The quality of the selected studies was assessed using the GRADE system. All the included studies reported on a multidisciplinary team implementing early mobilization which was feasible and safe in patients receiving ECMO. One study reported on reducing the duration of ECMO, two studies reported reducing ICU and hospital length of stay and reducing ICU and hospital mortality among ECMO patients receiving early mobilization.

Conclusions: An experienced, multidisciplinary team undertaking early mobilization seems feasible and safe. Early mobilization is beneficial in reducing critical care associated complications as well as reduces ICU and hospital length of stay in patients receiving ECMO.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

ARDS:

Acute respiratory distress syndrome

ECMO:

Extracorporeal membrane oxygenation

E-CPR:

Extracorporeal membrane oxygenation (ECMO) assisted cardiopulmonary resuscitation

ICU:

Intensive care unit

PICS:

Post-intensive care syndrome

prICULOS:

Prolonged ICU length of stay

PTSD:

Post-traumatic stress disorder

SCCM:

Society of Critical Care Medicine

VA-ECMO:

Veno-arterial extracorporeal membrane oxygenation

VV-ECMO:

Veno-venous extracorporeal membrane oxygenation

References

  1. Webb SA, Pettila V, Seppelt I, for the ANZIC Influenza Investigators, et al. Critical care services and 2009 H1N1 influenza in Australia and New Zealand. N Engl J Med. 2009;361(20):1925–34.

    Article  PubMed  Google Scholar 

  2. Zangrillo A, Biondi-Zoccai G, Landoni G, et al. Extracorporeal membrane oxygenation (ECMO) in patients with H1N1 influenza infection: a systematic review and meta-analysis including 8 studies and 266 patients receiving ECMO. Crit Care. 2013;17(1):R30.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Freed DH, Henzler D, White CW, et al. Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada. Can J Anaesth. 2010;57(3):240–7.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Sauer CM, Yuh DD, Bonde P. Extracorporeal membrane oxygenation use has increased by 433% in adults in the United States from 2006 to 2011. ASAIO J. 2015;61(1):31–6.

    Article  CAS  PubMed  Google Scholar 

  5. Lee H, Ko YJ, Suh GY, et al. Safety profile and feasibility of early physical therapy and mobility for critically ill patients in the medical intensive care unit: beginning experiences in Korea. J Crit Care. 2015;30(4):673–7.

    Article  PubMed  Google Scholar 

  6. Munshi L, Kobayashi T, DeBacker J, et al. Intensive care physiotherapy during extracorporeal membrane oxygenation for acute respiratory distress syndrome. Ann Am Thorac Soc. 2017;14(2):246–53.

    PubMed  Google Scholar 

  7. Chavez J, Bortolotto SJ, Paulson M, et al. Promotion of progressive mobility activities with ventricular assist and extracorporeal membrane oxygenation devices in a cardiothoracic intensive care unit. Dimens Crit Care Nurs DCCN. 2015;34(6):348–55.

    Article  PubMed  Google Scholar 

  8. Abrams D, Javidfar J, Farrand E, et al. Early mobilization of patients receiving extracorporeal membrane oxygenation: a retrospective cohort study. Crit Care. 2014;18(1):R38.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Rahimi RA, Skrzat J, Reddy DRS, et al. Physical rehabilitation of patients in the intensive care unit requiring extracorporeal membrane oxygenation: a small case series. Phys Ther. 2013;93(2):248–55.

    Article  PubMed  Google Scholar 

  10. Schweickert WD, Pohlman MC, Pohlman AS, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet. 2009;373 North American E(9678):1874–82.

    Article  PubMed  Google Scholar 

  11. Schmidt M, Pellegrino V, Combes A, et al. Mechanical ventilation during extracorporeal membrane oxygenation. Crit Care. 2014;18(1):203.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Peek GJ, Mugford M, Tiruvoipati R, et al. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. Lancet. 2009;374(9698):1351–63.

    Article  PubMed  Google Scholar 

  13. Sklar MC, Beloncle F, Katsios CM, et al. Extracorporeal carbon dioxide removal in patients with chronic obstructive pulmonary disease: a systematic review. Intensive Care Med. 2015;41(10):1752–62.

    Article  CAS  PubMed  Google Scholar 

  14. Buscher H, Vaidiyanathan S, Al-Soufi S, et al. Sedation practice in veno-venous extracorporeal membrane oxygenation: an international survey. ASAIO J. 2013;59(6):636–41.

    Article  CAS  PubMed  Google Scholar 

  15. Langer T, Santini A, Bottino N, et al. “Awake” extracorporeal membrane oxygenation (ECMO): pathophysiology, technical considerations, and clinical pioneering. Crit Care. 2016;20(1):150.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Gay S, Durand M, Casez M, et al. O-18 extubation after minimal sedation of patients treated with ECMO. J Cardiothorac Vasc Anesth. 2011;25(3):S8.

    Article  Google Scholar 

  17. Barr J, Fraser GL, Puntillo K, et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013;41(1):263–306.

    Article  PubMed  Google Scholar 

  18. Li Z, Peng X, Zhu B, et al. Active mobilization for mechanically ventilated patients: a systematic review. Arch Phys Med Rehabil. 2013;94(3):551–61.

    Article  PubMed  Google Scholar 

  19. Santos PMR, Ricci NA, Suster ÉAB, et al. Effects of early mobilisation in patients after cardiac surgery: a systematic review. Physiotherapy. 2017;103(1):1–12.

    Article  Google Scholar 

  20. Chen S, Su CL, Wu YT, et al. Physical training is beneficial to functional status and survival in patients with prolonged mechanical ventilation. J Formos Med Assoc. 2011;110(9):572–9.

    Article  PubMed  Google Scholar 

  21. Dong Z, Yu B, Zhang Q, et al. Early rehabilitation therapy is beneficial for patients with prolonged mechanical ventilation after coronary artery bypass surgery. Int Heart J. 2016;57(2):241–6.

    Article  CAS  PubMed  Google Scholar 

  22. Kayambu G, Boots R, Paratz J. Early physical rehabilitation in intensive care patients with sepsis syndromes: a pilot randomised controlled trial. Intensive Care Med. 2015;41(5):865–74.

    Article  PubMed  Google Scholar 

  23. Patman S, Sanderson D, Blackmore M. Physiotherapy following cardiac surgery: is it necessary during the intubation period? Aust J Physiother. 2001;47(1):7–16.

    Article  CAS  PubMed  Google Scholar 

  24. Hodgson C, Bellomo R, Berney S, et al, for the TEAM Study Investigation. Early mobilization and recovery in mechanically ventilated patients in the ICU: a bi-national, multi-centre, prospective cohort study. Crit Care. 2015;19:81.

    Google Scholar 

  25. Kayambu G, Boots R, Paratz J. Physical therapy for the critically ill in the ICU: a systematic review and meta-analysis. Crit Care Med. 2013;41(6):1543–54.

    Article  PubMed  Google Scholar 

  26. Kress JP. Clinical trials of early mobilization of critically ill patients. Crit Care Med. 2009;37:S442–7.

    Article  PubMed  Google Scholar 

  27. Schweickert WD, Kress JP. Implementing early mobilization interventions in mechanically ventilated patients in the ICU. Chest. 2011;140(6):1612–7.

    Article  PubMed  Google Scholar 

  28. Kram SL, DiBartolo MC, Hinderer K, et al. Implementation of the ABCDE bundle to improve patient outcomes in the intensive care unit in a rural community hospital. Dimens Crit Care Nurs. 2015;34(5):250–8.

    Article  PubMed  Google Scholar 

  29. Rehder KJ, Turner DA, Hartwig MG, et al. Active rehabilitation during extracorporeal membrane oxygenation as a bridge to lung transplantation. Respir Care. 2013;58(8):1291–8.

    Article  PubMed  Google Scholar 

  30. Garcia JP, Iaconao A, Kon ZN, et al. Ambulatory extracorporeal membrane oxygenation: a new approach for bridge-to-lung transplantation. J Thorac Cardiovasc Surg. 2010;139(6):e137–9.

    Article  PubMed  Google Scholar 

  31. Garcia JP, Kon ZN, Evans C, et al. Ambulatory veno-venous extracorporeal membrane oxygenation: innovation and pitfalls. J Thorac Cardiovasc Surg. 2011;142(4):755–61.

    Article  PubMed  Google Scholar 

  32. Shehabi Y, Bellomo R, Reade MC, et al. Early intensive care sedation predicts long-term mortality in ventilated critically ill patients. Am J Respir Crit Care Med. 2012;186(8):724–31.

    Article  PubMed  Google Scholar 

  33. Shehabi Y, Chan L, Kadiman S, et al. Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study. Intensive Care Med. 2013;39(5):910–8.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Tanaka LM, Azevedo LC, Park M, et al. Early sedation and clinical outcomes of mechanically ventilated patients: a prospective multicenter cohort study. Crit Care. 2014;18(4):R156.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Kerlin MP, Small DS, Cooney E, et al. A randomized trial of nighttime physician staffing in an intensive care unit. N Engl J Med. 2013;368(23):2201–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Kress JP, Pohlman AS, O’Connor MF, et al. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med. 2000;342(20):1471–7.

    Article  CAS  PubMed  Google Scholar 

  37. Girard TD, Kress JP, Fuchs BD, et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet. 2008;371(9607):126–34.

    Article  PubMed  Google Scholar 

  38. Strøm T, Martinussen T, Toft P. A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial. Lancet (London, England). 2010;375(9713):475.

    Article  Google Scholar 

  39. Balas MC, Vasilevskis EE, Olsen KM, et al. Effectiveness and safety of the awakening and breathing coordination, delirium monitoring/management, and early exercise/mobility (ABCDE) bundle. Crit Care Med. 2014;42(5):1024.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Ko Y, Cho YH, Park YH, et al. Feasibility and safety of early physical therapy and active mobilization for patients on extracorporeal membrane oxygenation. ASAIO J. 2015;61(5):564–8.

    Article  CAS  PubMed  Google Scholar 

  41. Boling B, Dennis DR, Tribble TA, et al. Safety of nurse-led ambulation for patients on venovenous extracorporeal membrane oxygenation. Prog Transplant (Aliso Viejo, Calif). 2016;26(2):112–6.

    Article  Google Scholar 

  42. Polastri M, Loforte A, Dell'Amore A, et al. Physiotherapy for patients on awake extracorporeal membrane oxygenation: a systematic review. Physiother Res Int. 2016;21(4):203–9.

    Article  PubMed  Google Scholar 

  43. Hein OV, Birnbaum J, Wernecke K, et al. Prolonged intensive care unit stay in cardiac surgery: risk factors and long-term-survival. Ann Thorac Surg. 2006;81(3):880–5.

    Article  PubMed  Google Scholar 

  44. Schelling G, Richter M, Roozendaal B, et al. Exposure to high stress in the intensive care unit may have negative effects on health-related quality-of-life outcomes after cardiac surgery. Crit Care Med. 2003;31(7):1971–80.

    Article  PubMed  Google Scholar 

  45. Jackson DL, Proudfoot CW, Cann KF, et al. The incidence of sub-optimal sedation in the ICU: a systematic review. Crit Care. 2009;13(6):R204.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Arora, R.C., Nagpal, D., Lamarche, Y., Sanjanwala, R., Szwajcer, A. (2019). When on ECMO: Awaken, Extubate and Mobilize. In: Lonchyna, V. (eds) Difficult Decisions in Cardiothoracic Critical Care Surgery. Difficult Decisions in Surgery: An Evidence-Based Approach. Springer, Cham. https://doi.org/10.1007/978-3-030-04146-5_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-04146-5_19

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-04145-8

  • Online ISBN: 978-3-030-04146-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics