Abstract
This chapter examines four of the most common drugs used in the prevention of postoperative atrial fibrillation in cardiac surgery. The pros and cons of each are weighed, and their effectiveness evaluated based on the best available studies. Finally, the authors’ personal view of the data and how we incorporate it into our practice is reviewed.
Keywords
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Maisel WH, Rawn JD, Stevenson WG. Atrial fibrillation after cardiac surgery. Ann Intern Med. 2001;125:1061–72.
Ho KM, Lewis JP. Prevention of atrial fibrillation in cardiac surgery: tie to consider a multimodality pharmacological approach. Cardiovasc Ther. 2010;28:59–65.
Mathew JP, Fontes ML, Tudor IC, et al. A multicenter risk index for atrial fibrillation after cardiac surgery. JAMA. 2004;291:1720–9.
Arsenault KA, Yusuf AM, Crystal E, et al. Interventions for preventing post-operative atrial fibrillation in patients undergoing heart surgery. Cochrane Database Syst Rev. 2013;1:CD003611.
Fuster V, Ryden LE, Cannom DS, et al. 2011ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2011;123(10):e269–367.
Burgess DC, Kilborn MJ, Keech AC. Interventions for prevention of post-operative atrial fibrillation and its complications after cardiac surgery: a meta-analysis. Eur Heart J. 2006;27:2846–57.
Ji T, Feng C, Sun L, et al. Are beta-blockers effective for preventing post-coronary artery bypass grafting atrial fibrillation? Direct and network meta-analyses. Ir J Med Sci. 2016;185:503–11.
Kerin NZ, Jacob S. The efficacy of sotalol in preventing postoperative atrial fibrillation: a meta-analysis. Am J Med. 2011;124(9):875.e1–9.
Mooss AN, Wurdeman RL, Sugimoto JT, et al. Amiodarone versus sotalol for the treatment of atrial fibrillation after open heart surgery: the Reduction in Postoperative Cardiovascular Arrhythmic Events (REDUCE) trial. Am Heart J. 2004;148:641–8.
Auer J, Weber T, Berent R, et al. A comparison between oral antiarrhythmic drugs in the prevention of atrial fibrillation after cardiac surgery: the pilot study of prevention of postoperative atrial fibrillation (SPPAF), a randomized, placebo-controlled trial. Am Heart J. 2004;147:636–43.
Kluger J, White CM. Amiodarone prevents symptomatic atrial fibrillation and reduces the rick of cerebrovascular accidents and ventricular tachycardia after open heart surgery: results of the atrial fibrillation suppression trial (AFIST). Card Electrophysiol Rev. 2003;7(2):165–7.
Daoud EG, Strickberger SA, Man KC, et al. Preoperative amiodarone as prophylaxis against atrial fibrillation after heart surgery. N Engl J Med. 1997;337(25):1785–91.
Redle JD, Khurana A, Marzan R, et al. Prophylactic oral amiodarone compared with placebo for prevention of atrial fibrillation after coronary artery bypass surgery. Am Heart J. 1999;138(1 Pt 1):144–50.
Maras D, Boskovic SD, Popovic Z, et al. Single-day loading dose of oral amiodarone for the prevention of new-onset atrial fibrillation after coronary artery bypass surgery. Am Heart J. 2001;141(5):E8.
Mitchell LB, Exner DV, Wyse DG, et al. Prophylactic oral amiodarone for the prevention of arrhythmias that begin early after revascularization, valve replacement, or repair; PAPABEAR: a randomized controlled trial. JAMA. 2005;294(24):3093–100.
Crystal E, Connolly SJ, Sleik K, et al. Interventions on prevention of postoperative atrial fibrillation in patients undergoing heart surgery: a meta-analysis. Circulation. 2002;196:75–80.
Patel AA, White CM, Gillespie EL, et al. Safety of amiodarone in the prevention of postoperative atrial fibrillation: a meta-analysis. Am J Health-Syst Pharm. 2006;63:829–37.
White CM, Ciri S, Tsikouris, et al. A comparison of two individual amiodarone regimens to placebo in open heart surgery patients. Ann Thorac Surg. 2002;74(1):69–74.
Miller S, Crystal E, Garfinkle M, et al. Effects of magnesium on atrial fibrillation after cardiac surgery: a meta-analysis. Heart. 2005;91:618–23.
Lancaster TS, Schill MR, Greenberg JW, et al. Potassium and magnesium supplementation do not protect against atrial fibrillation after cardiac operation: a time-matched analysis. Ann Thorac Surg. 2016;102:1181–9.
Gu WJ, Wu ZJ, Wang PF, et al. Intravenous magnesium prevents atrial fibrillation after coronary artery bypass grafting: a meta-analysis of 7 double-blind, placebo-controlled, randomized clinical trials. Trials. 2012;13:41.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Eridon, J.M., Ferguson, M.K. (2019). Prevention of Postoperative Atrial Fibrillation After Adult Cardiac Surgery. In: Lonchyna, V. (eds) Difficult Decisions in Cardiothoracic Critical Care Surgery. Difficult Decisions in Surgery: An Evidence-Based Approach. Springer, Cham. https://doi.org/10.1007/978-3-030-04146-5_15
Download citation
DOI: https://doi.org/10.1007/978-3-030-04146-5_15
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-04145-8
Online ISBN: 978-3-030-04146-5
eBook Packages: MedicineMedicine (R0)