Skip to main content
SpringerLink
Log in
Book cover

Metabolic Bone Diseases pp 169–182Cite as

Sclerotic Bone Disorders

  • Chapter
  • First Online:

  • 1008 Accesses

Abstract

Sclerotic bone diseases are heterogenous group characterized by increased bone density as a result of bone-remodeling abnormalities. Osteosclerosis results from increased osteoblastic and/or decreased osteoclastic activity resulting in trabecular bone thickening and subsequent increase in skeletal mass. These disorders can be hereditary/genetic bone disorders or acquired secondary to systemic disease, metabolic, or environmental factors. It is extremely important to diagnose localized or generalized sclerotic bone disease and identify the culprit as, in many cases, it can be treatable. Subsequent follow-up depends in large part on the causative factor with the goal to prevent fractures and deformities. In this chapter, we will review some of the known causes of osteosclerosis with a focus on metabolic and acquired causes.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Abbreviations

BMD:

Bone mineral density

CKD-MBD:

Chronic kidney disease-mineral and bone disorder

DXA:

Dual-energy X-ray absorptiometry

HOA:

Hypertrophic osteoarthropathy

References

  1. Whyte MP, McAlister WH, Novack DV, Clements KL, Schoenecker PL, Wenkert D. Bisphosphonate-induced osteopetrosis: novel bone modeling defects, metaphyseal osteopenia, and osteosclerosis fractures after drug exposure ceases. J Bone Miner Res. 2008;23(10):1698–707.

    Article  Google Scholar 

  2. Driessen GJ, Gerritsen EJ, Fischer A, Fasth A, Hop WC, Veys P, et al. Long-term outcome of haematopoietic stem cell transplantation in autosomal recessive osteopetrosis: an EBMT report. Bone Marrow Transplant. 2003;32(7):657–63.

    Article  CAS  Google Scholar 

  3. Sly WS, Hewett-Emmett D, Whyte MP, Yu YS, Tashian RE. Carbonic anhydrase II deficiency identified as the primary defect in the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification. Proc Natl Acad Sci U S A. 1983;80(9):2752–6.

    Article  CAS  Google Scholar 

  4. Olan F, Portela M, Navarro C, Gaxiola M, Silveira LH, Ruiz V, et al. Circulating vascular endothelial growth factor concentrations in a case of pulmonary hypertrophic osteoarthropathy. Correlation with disease activity. J Rheumatol. 2004;31(3):614–6.

    PubMed  Google Scholar 

  5. Uppal S, Diggle CP, Carr IM, Fishwick CW, Ahmed M, Ibrahim GH, et al. Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy. Nat Genet. 2008;40(6):789–93.

    Article  CAS  Google Scholar 

  6. Slobodin G, Rosner I, Feld J, Rimar D, Rozenbaum M, Boulman N, et al. Pamidronate treatment in rheumatology practice: a comprehensive review. Clin Rheumatol. 2009;28(12):1359–64.

    Article  Google Scholar 

  7. Moorthi RN, Moe SM. CKD-mineral and bone disorder: core curriculum 2011. Am J Kidney Dis. 2011;58(6):1022–36.

    Article  Google Scholar 

  8. Bakkaloglu SA, Wesseling-Perry K, Pereira RC, Gales B, Wang HJ, Elashoff RM, et al. Value of the new bone classification system in pediatric renal osteodystrophy. Clin J Am Soc Nephrol. 2010;5(10):1860–6.

    Article  CAS  Google Scholar 

  9. Picolos MK, Lavis VR, Orlander PR. Milk-alkali syndrome is a major cause of hypercalcaemia among non-end-stage renal disease (non-ESRD) inpatients. Clin Endocrinol (Oxf). 2005;63(5):566–76.

    Article  Google Scholar 

  10. Picolos MK, Sims CR, Mastrobattista JM, Carroll MA, Lavis VR. Milk-alkali syndrome in pregnancy. Obstet Gynecol. 2004;104(5 Pt 2):1201–4.

    Article  Google Scholar 

  11. Beall DP, Scofield RH. Milk-alkali syndrome associated with calcium carbonate consumption. Report of 7 patients with parathyroid hormone levels and an estimate of prevalence among patients hospitalized with hypercalcemia. Medicine (Baltimore). 1995;74(2):89–96.

    Article  CAS  Google Scholar 

  12. Biesalski HK. Comparative assessment of the toxicology of vitamin A and retinoids in man. Toxicology. 1989;57(2):117–61.

    Article  CAS  Google Scholar 

  13. Penniston KL, Tanumihardjo SA. The acute and chronic toxic effects of vitamin A. Am J Clin Nutr. 2006;83(2):191–201.

    Article  CAS  Google Scholar 

  14. Sina Jasim DW, Robert A. Wermers. Skeletal fluorosis related to habitual tea consumption: long-term follow up after reduction and discontinuation of tea. AACE Clinical case reports. 2017.

    Google Scholar 

  15. Mennel EA, John SD. Osteosclerotic metaphyseal dysplasia: a skeletal dysplasia that my mimic lead poisoning in a child with hypotonia and seizures. Pediatr Radiol. 2003;33:11–4.

    Article  Google Scholar 

  16. Whyte MP. Primer on the metabolic bone diseases and disorders of mineral metabolism. 8th edition. 2013

    Chapter  Google Scholar 

Download references

Conflict of Interest

  • All authors state that they have no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Internal Medicine and Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA

    Sina Jasim

  2. Department of Medicine and Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN, USA

    Robert Wermers & Daniel L. Hurley

Authors
  1. Sina Jasim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert Wermers
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Daniel L. Hurley
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Daniel L. Hurley .

Editor information

Editors and Affiliations

  1. Division of Endocrinology and Metabolism, Loyola University Medical Center, Maywood, IL, USA

    Pauline M. Camacho

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Jasim, S., Wermers, R., Hurley, D.L. (2019). Sclerotic Bone Disorders. In: Camacho, P. (eds) Metabolic Bone Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-03694-2_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-03694-2_12

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-03693-5

  • Online ISBN: 978-3-030-03694-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation