Skip to main content

Laboratory and Immunological Tests in Rheumatology

  • Chapter
  • First Online:
Illustrated Handbook of Rheumatic and Musculo-Skeletal Diseases

Abstract

A wide spectrum of various laboratory and immunological tests are available in the everyday clinical practice for patients with rheumatic diseases. Some tests help physicians in establishing a diagnosis or simply categorising/classifying a suspected disease. Others, demonstrate the extent but also the nature of any pathological changes, while others are necessary to monitor disease activity of an inflammatory disorder and help the physician to assess the therapeutic response.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References and Further Reading

  • De Vita S, Soldano F, Isola M, Monti G, Gabrielli A, Tzioufas A, Ferri C, Ferraccioli GF, Quartuccio L, Corazza L, De Marchi G, Ramos Casals M, Voulgarelis M, Lenzi M, Saccardo F, Fraticelli P, Mascia MT, Sansonno D, Cacoub P, Tomsic M, Tavoni A, Pietrogrande M, Zignego AL, Scarpato S, Mazzaro C, Pioltelli P, Steinfeld S, Lamprecht P, Bombardieri S, Galli M. Preliminary classification criteria for the cryoglobulinaemic vasculitis. Ann Rheum Dis. 2011;70(7):1183–90.

    Article  Google Scholar 

  • Meroni PL, Schur PH. ANA screening: an old test with new recommendations. Ann Rheum Dis. 2010. https://doi.org/10.1136/ard.2009.127100.

    Article  CAS  Google Scholar 

  • Morehead K. Evaluation of the patient – B. Laboratory assessment. In: Primer of the rheumatic diseases. 13th ed. New York: Springer; 1998.

    Google Scholar 

  • Quartuccio L, Isola M, Corazza L, Ramos-Casals M, Retamozo S, Ragab GM, Zoheir MN, El-Menyawi MA, Salem MN, Sansonno D, Ferraccioli G, Gremese E, Tzioufas A, Voulgarelis M, Vassilopoulos D, Scarpato S, Pipitone N, Salvarani C, Guillevin L, Terrier B, Cacoub P, Filippini D, Saccardo F, Gabrielli A, Fraticelli P, Sebastiani M, Tonsic M, Tavoni A, Mazzaro C, Pioltelli P, Nishimoto N, Scaini P, Zignego AL, Ferri C, Monti G, Pietrogrande M, Bombardieri S, Galli M, De Vita S. Validation of the classification criteria for cryoglobulinaemic vasculitis. Rheumatology (Oxford). 2014;53(12):2209–13.

    Article  Google Scholar 

  • Scholz J, Grossmann K, Knutter I, Hiermann R, Sowa M, Rober N, Rodiger S, Schierack P, Reinhold D, Bogdanos DP, Meroni PL, Radice A, Conrad K, Roggenbuck D. Second generation analysis of antinuclear antibody (ANA) by combination of screening and confirmatory testing. Clin Chem Lab Med. 2015;53(12):1991–2002.

    Article  CAS  Google Scholar 

  • Toes R, Zirkzee E, Mariette X. Immunology and the rheumatic diseases. In: EULAR textbook on rheumatic diseases. 2nd ed. London: BMJ; 2012.

    Google Scholar 

  • Tzioufas AG, Manoussakis MN, Costello R, Silis M, Papadopoulos NM, Moutsopoulos HM. Cryoglobulinemia in autoimmune rheumatic diseases. Evidence of circulating monoclonal cryoglobulins in patients with primary Sjögren’s syndrome. Arthritis Rheum. 1986;29(9):1098–104.

    Article  CAS  Google Scholar 

  • Tzioufas AG, Manoussakis MN, Drosos AA, Silis G, Gharavi AE, Moutsopoulos HM. Enzyme immunoassays for the detection of IgG and IgM anti-dsDNA antibodies: clinical significance and specificity. Clin Exp Rheumatol. 1987;5(3):247–53.

    CAS  PubMed  Google Scholar 

  • Tzioufas AG, Terzoglou C, Stavropoulos ED, Athanasiadou S, Moutsopoulos HM. Determination of anti-ds-DNA antibodies by three different methods: comparison of sensitivity, specificity and correlation with lupus activity index (LAI). Clin Rheumatol. 1990;9(2):186–92.

    Article  CAS  Google Scholar 

  • Tzioufas AG, Katsikis PD, Youinou PY, Moutsopoulos HM. Sjögren’s syndrome: an oligo-monoclonal B-cell process. Clin Exp Rheumatol. 1990;8(Suppl 5):17–21.

    PubMed  Google Scholar 

  • Tzioufas A, Wassmuth R, Dafni U, Guialis A, Haga H, Isenberg D, Jonsson R, Kalden J, Kiener H, Sakarellos C, Smolen J, Sutcliffe N, Vitali C, Yiannaki E, Moutsopoulos H. Clinical, immunological, and immunogenetic aspects of autoantibody production against Ro/SSA, La/SSB and their linear epitopes in primary Sjögren’s syndrome (pSS): a European multicenter study. Ann Rheum Dis. 2002;61(5):398–404.

    Article  CAS  Google Scholar 

  • Vossenaar ER, Zendman AJ, van Venrooij WJ, Pruijn GJ. PAD a growing family of citrullinating enzymes: genes, features and involvement in disease. BioEssays. 2003;25(11):1106–18.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Pelechas, E., Kaltsonoudis, E., Voulgari, P.V., Drosos, A.A. (2019). Laboratory and Immunological Tests in Rheumatology. In: Illustrated Handbook of Rheumatic and Musculo-Skeletal Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-03664-5_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-03664-5_2

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-03663-8

  • Online ISBN: 978-3-030-03664-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics