Meta-analysis of the Immunomodulatory Effect of Ganoderma Lucidum Spores Using an Automatic Pipeline

  • Rui Liu
  • Yumeng Zhang
  • Ziwen Chen
  • Liqiang Wang
  • Shuaibing He
  • Guifeng Hua
  • Chang LiuEmail author
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 10983)


Although many studies have been conducted on the chemistry and pharmacological activities of Ganoderma lucidum spores (GLS), there is a lack of systematic review on the health promoting functions especially immunomodulatory effects of GLS. In the current study, we constructed a data model and utilized R modules and PERL language to implement a pipeline that is capable of carrying out multiple meta-analyses automatically. Using GLS as the study subject, we carried out meta-analyses on 53 outcome measures using the automatic meta-analysis pipeline. Among them, 19 outcome measures were found to be significantly affected after GLS treatment (with p value < 0.05). 8 of them have I^2 less than 50%, indicating low level of study heterogeneity. Through the analysis of GLS, the automatic meta-analysis pipeline has been shown to be suitable for high-throughput meta-analysis and visualization. Also, the information derived from this study could assist policy-makers and functional food consumers to determine whether GLS could be a recommended choice for immunomodulatory effect.


Ganoderma lucidum spore Meta-analysis Immunomodulatory effect 



This work was supported by grants from CAMS Innovation Fund for Medical Sciences (CIFMS) (2016-I2M-3-016 and 2017-I2M-1-013), From the Chinese Academy of Medical Science.


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Rui Liu
    • 1
  • Yumeng Zhang
    • 1
  • Ziwen Chen
    • 1
  • Liqiang Wang
    • 2
  • Shuaibing He
    • 2
  • Guifeng Hua
    • 1
  • Chang Liu
    • 2
    Email author
  1. 1.Central China Normal UniversityWuhanChina
  2. 2.Institute of Medicinal Plant DevelopmentChinese Academy of Medical ScienceBeijingChina

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