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Endophytic Fungi: Promising Source of Novel Bioactive Compounds

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Advances in Endophytic Fungal Research

Part of the book series: Fungal Biology ((FUNGBIO))

Abstract

Natural products have been used since earliest times for the treatment of several ailments. They offer excellent prospects for discovery of bioactive compounds and are the basis for the synthesis of effective drugs. Natural products from endophytic fungi of medicinal plants have been recognized as potential sources of bioactive compounds. Endophytes exemplify a diverse microbial community that exists in distinct environments and their diversity in these unique habitats benefits in the exploration of novel bioactive compounds. Fungal endophytes occur ubiquitously in plants and are generally asymptomatic within the host plants. The mutualistic association of a plant with an endophyte could influence the production of analogous bioactive compounds as the host plant. An understanding of biologically active compound production mechanism and their activity is essential for the development of new compounds in the drug discovery process. From the time when taxol, a potent anticancer compound was discovered, research on endophytic fungi has gained momentum and yielded several compounds with antibacterial, antiviral, antioxidant, immunosuppressant, anti-inflammatory, anti-diabetic, and anticancer properties. The main focus of this chapter is to provide a concise approach to the origin, classification, host-endophyte symbiosis, and the endophytic fungal role in diverse areas such as plant growth enhancers, antimicrobials, anticancer agents, and antioxidants. This chapter aims to highlight the potential benefits of secondary metabolites of endophytic fungi in varied fields which are valuable to mankind.

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Authors and Affiliations

  1. Fungal Metabolite Research Laboratory, Department of Microbiology and Biotechnology, Bangalore University, Jnanabharathi Campus, Bangalore, Karnataka, India

    Fazilath Uzma & Srinivas Chowdappa

  2. Department of Studies in Molecular Biology, University of Mysore, Manasagangotri, Mysore, Karnataka, India

    Chakrabhavi D. Mohan

  3. Department of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysore, Karnataka, India

    Chandra N. Siddaiah

Authors
  1. Fazilath Uzma
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  2. Chakrabhavi D. Mohan
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  3. Chandra N. Siddaiah
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  4. Srinivas Chowdappa
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Editors and Affiliations

  1. Molecular Microbiology and Systematics Laboratory, Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India

    Bhim Pratap Singh

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Uzma, F., Mohan, C.D., Siddaiah, C.N., Chowdappa, S. (2019). Endophytic Fungi: Promising Source of Novel Bioactive Compounds. In: Singh, B. (eds) Advances in Endophytic Fungal Research. Fungal Biology. Springer, Cham. https://doi.org/10.1007/978-3-030-03589-1_12

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