Abstract
Plants are the primary sources for most of the food items for all organisms. Human beings have also used plants for purposes other than food, for example, for making tools and houses as well as medicine. Most of the civilizations have a rich history of traditional medicine based on plant extracts or preparations. In last few centuries, the active compounds from plants have been isolated and characterized. These active compounds belong to class of molecules called as secondary metabolites which are further divided into several subclasses: alkaloids, polyphenols, flavonoids, and terpenes. Polyphenols are a large group of secondary metabolites in plants. They are widely distributed among the plant species and are found in vegetables, fruits, and beans for tea and coffee. The common examples of polyphenols are flavonoids, phenolic acids, and lignans. There are many biological and pharmacological activities attributed to the phenolic acids. They have antioxidant, anti-inflammatory, and cytoprotective properties. With the emergence of diabetes as major metabolic disorder, there has been a search for natural compounds. In last two decades, there are many reports which have suggested the role of phenolic acids in the prevention of glycation-mediated secondary complications of diabetes. This chapter deals with the recent advances in the field of phenolic acids and their application in the treatment of disorders like diabetes and neurodegeneration.
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Abbreviations
- AGE:
-
Advanced glycation end product
- PRP:
-
Proline-rich proteins
- RNS:
-
Reactive nitrogen species
- ROS:
-
Reactive oxygen species
- SOM:
-
Soil organic matter
References
Aherne SA, O’Brien NM (2002) Dietary flavanols: chemistry, food content and metabolism. Nutrition 18:75–81
Ahmed N (2005) Advanced glycation end-products - role in pathology of diabetic complications. Diabetes Res Clin Pract 67:3–21
Ali A, Sharma R, Sivakami S (2014) Role of natural compounds in the prevention of DNA and proteins damage by glycation. Bionano Front 7:25–30
Alov P, Tsakovska I, Pajeva I (2015) Computational studies of free radical- scavenging properties of phenolic compounds. Curr Top Med Chem 15:85–104
Anani K, Adjrah Y, Ameyapoh Y, Karou SD, Agbonon A, de Souza C, Gbeassor M (2015) Effects of hydroethanolic extracts of Balanitesaegyptiaca (L.) Delile (Balanitaceae) on some resistant pathogens bacteria isolated from wounds. J Ethnopharmacol 164:16–21
Apostolidis E, Kwon YI, Shetty K (2006) Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pac J Clin Nutr 15:433–441
Apostolidis E, Kwon YI, Shetty K (2007) Inhibitory potential of herb, fruit, and fungal-enriched cheese against key enzymes linked to type 2 diabetes and hypertension. Inn Food Sci Emerg Technol 8:46–54
Appel HM (1993) Phenolics in ecological interactions: the importance of oxidation. J Chem Ecol 19(7):1521–1552
Arct J, Bielenda B, Oborska A, Pytkowska K (2003) The tea and its cosmetic application. J Appl Cosmetol 21:117–127
Arct J, Pytkowska K (2008) Flavonoids as components of biologically active cosmeceuticals. Clin Dermatol 26:347–357
Ashok PK, Upadhyaya K (2012) Tannins are astringent. J Pharmacogn Phytochem 1:45–50
Ayres DC, Loike JD (1990) Lignans: chemical, biological & clinical properties. Cambridge University Press, Cambridge, UK
Bakkalbasi E, Mentes O, Artik N (2009) Food ellagitannins— occurrence, effects of processing and storage. Crit Rev Food Sci Nutr 49:283–298
Banan P, Ali A (2016) Preventive effect of phenolic acids on in vitro glycation. Ann Phytomed 5:97–102
Bazzocco S, Mattila I, Guyot S (2008) Factors affecting the conversion of apple polyphenols to phenolic acids and fruit matrix to short-chain fatty acids by human faecalmicrobiota in vitro. Eur J Nutr 47:442–452
Beninger CW, Gu L, Prior RL (2007) Changes in polyphenols of the seed coat during the after-darkening process in pinto beans (Phaseolus vulgaris L.). J Agric Food Chem 53:7777–7782
Berrou J, Tostivint I, Verrecchia F, Berthier C, Boulanger E, Mauviel A, Marti HP, Wautier MP, Wautier JL, Rondeau E, Hertig A (2009) Advanced glycation end-products regulate extracellular matrix protein and protease expression by human glomerular mesangial cells. Int J Mol Med 23:513–520
Bitsch R (1996) Pflanzen Phenol und ihregesundheitlicheWirkung. Natwiss Rundsch 2:47–51
Booker FL, Maier CA (2001) Atmospheric carbon dioxide, irrigation, and fertilization effects on phenolic and nitrogen concentrations in loblolly pine (Pinus taeda) needles. Tree Physiol 21(9):609–616
Bragazza L, Freeman C, Jones T (2006) Atmospheric nitrogen deposition promotes carbon loss from peat bogs. Proc Natl Acad Sci U S A 103(51):19386–19389
Bravo L (1998) Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev 56(11):317–333
Breinholt V (1999) Desirable versus harmful levels of intake of flavonoids and phenolic acids. In: Kumpulainen JT, Salonen JT (eds) Natural antioxidants and anticarcinogens in nutrition, health and disease. The Royal Society of Chemistry, London, UK, pp 93–99
Buendia B, Gil MI, Tudela JA (2010) HPLC-MS analysis of proanthocyanidin oligomers and other phenolics in 15 strawberry cultivars. J Agric Food Chem 58:3916–3926
Cai K, Bennick A (2006) Effect of salivary proteins on the transport of tannin and quercetin across intestinal epithelial cells in culture. Biochem Pharmacol 72:974–980
Cai H, Xie Z, Liu G, Sun X, Peng G, Lin B, Liao Q (2014) Isolation, identification and activities of natural antioxidants from Callicarpa kwangtungensis chun. PLoS One 9:160
Castelluccio C, Paganga G, Melikian N, Bolwell GP, Pridham J, Sampson J, Rice-Evans C (1995) Antioxidant potential of intermediates in phenylpropanoid metabolism in higher plants. FEBS Lett 368:188–192
Cinta B, Lluis A, Salvado M (2010) Hypolipidemic effects of proanthocyanidins and their underlying biochemical and molecular mechanisms. Mol Nutr Food Res 54:37–59
Clifford M, Scalbert A (2000) Ellagitannins—nature, occurrence and dietary burden. J Sci Food Agric 80:1118–1125
Czemplik M, Zuk M, Kulma A, Kuc S, Szopa J (2011) GMflax as a source of effective antimicrobial compounds. Sci Microb Pathog Commun Curr Res Technol Adv 76:39–47
Decker EA (1995) Phenolics: prooxidants or antioxidants? Nutr Rev 10:210–219
Drynan JW, Clifford MN, Obuchowicz J, Kuhnert N (2010) The chemistry of low molecular weight black tea polyphenols. Nat Prod Rep 27:417–462
Dudonne S, Poupard P, Coutiere P, Woillez M, Richard T, Merillon JM, Vitrac X (2011) Phenolic composition and antioxidant properties of poplar bud (Populus nigra) extract: Individual antioxidant contribution of phenolics and transcriptional effect on skin aging. J Agric Food Chem 59:4527–4536
Ellis T, Hill PW, Fenner N, Williams GG, Godbold D, Freeman C (2009) The interactive effects of elevated carbon dioxide and water table drawdown on carbon cycling in a Welsh ombrotrophic bog. Ecol Eng 35(6):978–986
Evans WC (1996) Trease and Evans’ pharmacognosy, 14th edn. Harcourt Brace and Co, Singapore, pp 273–275
Fernández de SB, Hernández T, Estrella I, Gómez-Cordovés C (1992) Variation in phenol content in grapes during ripening: Low-molecular-weight phenols. Z Lebensm Unters Forsch 194:351–354
Freeman C, Fenner N, Ostle NJ (2004) Export of dissolved organic carbon from peatlands under elevated carbon dioxide levels. Nature 430(6996):195–198
Gil MI, Tomas-Barberan FA, Hess-Pierce B, Holcroft DM, Kafer AA (2000) Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem 48:4581–4589
Gotham J (1989) Methods in plant biochemistry. In: Harborne JB (ed) Plant phenolics, vol Vol. 1. Academic Press, London, UK, pp 78–96
Harbowy ME, Balentine DA (1997) Tea chemistry. CRC Crit Rev Plant Sci 16:415–480
Haslam E (2003) Thoughts on thearubigins. Phytochemistry 64:61–73
Hasna E (2009) Polyphenols: food sources, properties and applications - a review. Int J Food Sci Technol 44:2512–2518
Hättenschwiler S, Vitousek PM (2000) The role of polyphenols in terrestrial ecosystem nutrient cycling. Trends Ecol Evol 15(6):238–242
Heldt HW, Heldt F (1997) Plant biochemistry and molecular biology. Oxford University Press, Oxford; New York
Heleno SA, Martins A, Queiroz MJ, Ferreira IC (2015) Bioactivity of phenolic acids: Metabolites versus parent compounds: A review. Food Chem 173:501–513
Hertog MGL, Hollman PCH, Katan MB, Kromhout (1993) Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. D Nutr Cancer 20:21–29
Ho CT (1993) In: Ohigashi H, Osawa T, Terao J, Walanabe S, Yoshikawa T (eds) Food factors for cancer prevention. Springer, Tokyo, Japan, pp 593–597
Horner JD, Gosz JR, Cates RG (1988) The role of carbon-based plant secondary metabolites in decomposition in terrestrial ecosystems. Am Nat 132:869–883
Huang MT, Ferraro T (1882) In: Huang MT, Ho CT, Lee CY (eds) Phenolic compounds in food and their effects on health II: antioxidants & cancer prevention. American Chemical Society, Washington, D.C, pp 8–34
Jang M, Cai L, Udeani GO, Slowing ΚV, Thomas CF, Beecher CWW, Fong HHS, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275:218–220
Kang MH, Naito M, Tsujihara N, Osawa T (1998) Sesamolin inhibits lipid peroxidation in rat liver and kidney. J Nutr 128:1018–1022
Kennedy JA, Hayasaka Y, Vidal S (2001) Composition of grape skin proanthocyanidins at different stages of berry development. J Agric Food Chem 49:5348–5355
Khaki A, Fatemek F, Mohammad N, Amir AK, Chelar CO, Marefat N (2009) The effects of ginger on spermatogenesis and sperm parameters. Iran J Reprod Med 7(1):7–12
Koponen JM, Happonen AM, Mattila PH, Torronen AR (2007) Contents of anthocyanins and ellagitannins in selected foods consumed in Finland. J Agric Food Chem 55:1612–1619
Kostolanska J, Jakus V, Barak L (2009) Monitoring of early and advanced glycation in relation to the occurrence of microvascular complications in children and adolescents with type 1 diabetes mellitus. Physiol Res 58:553–561
Kraus TEC, Zasoski RJ, Dahlgren RA (2004) Fertility and pH effects on polyphenol and condensed tannin concentrations in foliage and roots. Plant Soil 262(1–2):95–109
Kuhnert N, Drynan JW, Obuchowicz J (2010) Mass spectrometric characterization of black tea thearubigins leading to an oxidative cascade hypothesis for thearubigin formation. Rapid Commun Mass Spectrom 24:3387–3404
Kurzer MS, Xu X (1997) Dietary phytoestrogens. Annu Rev Nutr 17:353–381
Langley RG, Krueger GG, Griffiths CE (2005) Psoriasis: Epidemiology, clinical features, and quality of life. Ann Rheum Dis 64(Suppl. 2):ii18–ii23
Lin D, Xiao M, Zhao J, Li Z, Xing B, Li X, Kong M, Li L, Zhang Q, Liu Y, Chen H, Qin W, Wu H, Chen S (2016) An overview of plant phenolic compounds and their importance in human nutrition and management of Type 2 Diabetes. Molecules 21:2–19
Lin JK (2004) In: Meskin MS, Bidlack WR, Davies AJ, Lewis D, Randolph RK (eds) Phytochemicals: mechanisms of action. CRC Press, Boca Raton, FL, pp 79–108
Liu W, Wei Z, Ma H, Cai A, Liu Y, Sun J, DaSilva NA, Johnson SL, Kirschenbaum LJ, Cho BP, Dain JA, Rowley DC, Shaikh ZA, Seeram NPV (2017) Anti-glycation and anti-oxidative effects of a phenolic-enriched maple syrup extract and its protective effects on normal human colon cells. Food Funct 82:757–766
Macheix JJ, Fleuriet Α, Billot J (1990) Fruit phenolics. CRC Press, Boca Raton, FL
Manach C, Hubert J, Llorach R, Scalbert A (2009) Review: the complex links between dietary phytochemicals and human health deciphered by metabolomics. Mol Nutr Food Res 53:1303–1315
Mane C, Souquet JM, Olle D (2007) Optimization of simultaneous flavanol, phenolic acid, and anthocyanin extraction from grapes using an experimental design: application to the characterization of Champagne grape varieties. J Sci Food Agric 55:7224–7233
Mattivi F, Guzzon R, Vrhovsek U (2006) Metabolite pro- filing of grape: flavonols and anthocyanins. J Agric Food Chem 54:7692–7702
McDougall GJ, Shpiro F, Doboson P, Smith P, Blake A, Stewart D (2005) Different polyphenolic compounds of soft fruits inhibit α-amylase and α-glucosidase. J Agric Food Chem 53:2760–2766
Milder IE, Arts IC, van de Putte B, Venema DP, Hollman PC (2005) Lignan contents of Dutch plant foods: a database including lariciresinol, pinoresinol, secoisolariciresinol and matairesinol. Br J Nutr 93:393–402
Moo-Huchin VM, Moo-Huchin MI, Estrada-León RJ, Cuevas-Gloryc L, Estrada-Motaa IA, Ortiz-Vázquezc E, Betancur-Anconad D, Sauri-Duchc E (2015) Antioxidant compounds, antioxidant activity and phenolic content in peel from three tropical fruits from Yucatan, Mexico. Food Chem 166:17–22
Nadkarni KM (1998) Indian materiamedica, 3rd edn. Bombay Popular Prakashan, Mumbai, pp 830–834
Norby RJ, Cotrufo MF, Ineson P, O'Neill EG, Canadell JG (2001) Elevated CO2, litter chemistry, and decomposition: a synthesis. Oecologia 127(2):153–165
Nybakken L, Johansson O, Palmqvist K (2009) Defensive compound concentration in boreal lichens in response to simulated nitrogen deposition. Glob Chang Biol 15(9):2247–2260
Ollis WD, Brown AG, Haslam E (1966) The constitution of theaflavin. Tetrahedron Lett 1193–1204
Ososki AL, Kennelly EJ (2009) Phytoestrogens: A review of the present state of research. Phytother Res 17:845–869
Oszmianski J, Wojdylo A (2009) Comparative study of phenolic content and antioxidant activity of strawberry puree, clear, and cloudy juices. Eur Food Res Technol 228:623–631
Ozo NO, Caygill JC (1986) O-dihydroxyphenoloxidase action on natural polyhydric phenolics and enzymic browning of edible yams. J Sci Food Agric 37:283–288
Pastore S, Potapovich A, Kostyuk V, Mariani V, Lulli D, de Luca C, Korkina L (2009) Plant Polyphenols Effectively Protect Hacat Cells from Ultraviolet C-Triggered Necrosis and Suppress Inflammatory Chemokine Expression. Ann N Y Acad Sci 1171:305–313
Penuelas J, Estiarte M (1998) Can elevated carbon dioxide affect secondary metabolism and ecosystem function? Trends Ecol Evol 13(1):20–24
Pinho E, Ferreira IC, Barros L, Carvalho AM, Soares G, Henriques M (2014) Antibacterial potential of northeastern Portugal wild plant extracts and respective phenolic compounds. Biomed Res Int 2014:814590
Pourcel L, Routaboul JM, Cheynier V (2007) Flavonoid oxidation in plants: from biochemical properties to physiological functions. Trends Plant Sci 12:29–36
Quideau S, Deffieux D, Douat-Casassus C, Pouyse’gu L (2011) Plant polyphenols: chemical properties, biological activities, and synthesis. Angew Chem Int Ed Engl 50:586–621
Raisanen T, Ryyppo A, Julkunen-Tiitto R, Kellomaki S (2008) Effects of elevated carbon dioxide and temperature on secondary compounds in the needles of Scots pine (Pinus sylvestris). Trees 22(1):121–135
Rhein LD, Fluhr JW (2010) Aging skin: current and future therapeutic strategies. Allured Business Media, Carol Stream, IL, USA, pp 182–184, 225–240
Roberts EAH, Cartwright RA, Oldschool M (1959) The phenolic substances of manufactured tea. I. Fractionation and paper chromatography of water-soluble substances. J Sci Food Agric 8:72–80
Sadowska-Bartosz I, Bartosz G (2014) Effect of antioxidants supplementation on aging and longevity. Biomed Res Int 2014:404680
Sapis JC, Macheix JJ, Cordonnier RE (1983) The browning capacity of grapes. II. Browning potential and polyphenol oxidase activities in different mature grape varieties [Red and white]. J Agric Food Chem 31:342–345
Schroder H (2007) Protective mechanisms of the Mediterranean diet in obesity and type 2 diabetes. J Nutr Biochem 18:149–160
Shin S, Lee J, Kim M, Kum H, Jung E, Park D (2015) Anti-glycation activities of phenolic constituents from Silybum marianum (Milk Thistle) flower in vitro and on human explants. Molecules 20:549–564
Siegenthaler A, Buttler A, Bragazza L (2010) Litter- and ecosystem-driven decomposition under elevated CO2 and enhanced N deposition in a Sphagnum peatland. Soil Biol Biochem 42(6):968–977
Sies H (2010) Polyphenols and health: update and perspectives. Arch Biochem Biophys 501:2–5
Sinsabaugh RL (2010) Phenol oxidase, peroxidase and organic matter dynamics of soil. Soil Biol Biochem 42(3):391–404
Tanaka T, Matsuo Y, Kouno I (2010) Chemistry of secondary polyphenols produced during processing of tea and selected foods. Int J Mol Sci 11:14–40
Taylor SL, Higley ΝΑ, Bush RK (1986) Sulfites in foods: uses, analytical methods, residues, fate, exposure assessment, metabolism, toxicity, and hypersensitivity. Adv Food Res 30:1–76
Toberman H, Laiho R, Evans CD (2010) Long-term drainage for forestry inhibits extracellular phenol oxidase activity in Finnish boreal mire peat. Eur J Soil Sci 61(6):950–957
Torronen R (2009) Sources and health effects of dietary ellagitannins. In: Quideau S (ed) Chemistry and biology of ellagitannins—an underestimated class of bioactive plant polyphenols. World Scientific, Singapore, pp 298–319
Tsuda T (2008) Regulation of adipocyte function by anthocyanins: possibility of preventing the metabolic syndrome. J Agric Food Chem 56:642–646
Ucle´s SJR, Bakry FB, Rillouet JM (2010) A preliminary chemotaxonomic study on the condensed tannins of green banana flesh in the Musa genus. Biochem Syst Ecol 38:1010–1017
Umukoro S, Ashorobi RB (2007) Further studies on the antinociceptive action of aqueous seed extract of Aframomum melegueta. J Ethnopharmacol 109:501–504
Veteli TO, Mattson WJ, Niemella P (2007) Do elevated temperature and carbon dioxide generally have counteracting effects on phenolic phytochemistry of boreal trees? J Chem Ecol 33(2):287–296
Wilson T, Singh AP, Vorsa N (2008) Human glycemic response and phenolic content of unsweetened cranberry juice. J Med Food 11:46–54
Wojdylo A, Oszmianski J, Laskowski P (2008) Polyphenolic compounds and antioxidant activity of new and old apple varieties. J Agric Food Chem 56:6520–6530
Wu LC, Prior R (2005a) Systematic identification and characterization of anthocyanins by HPLC-ESI-MS/MS in common foods in the United States: fruits and berries. J Agric Food Chem 53:2589–2599
Wu LC, Prior R (2005b) Identification and characterization of anthocyanins by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry in common foods in the United States: vegetables, nuts, and grains. J Agric Food Chem 53:3101–3113
Wu T, He M, Zang X, Zhou Y, Qiu T, Pan S, Xu X (2013, 1828) A structure-activity relationship study of flavonoids as inhibitors of E. coli by membrane interaction effect. Biochim Biophys Acta BBA Biomem:2751–2756
Yi W, Wetzstein HY (2010) Biochemical, biological and histological evaluation of some culinary and medicinal herbs grown under greenhouse and field conditions. J Sci Food Agric 90(6):1063–1070
Yoo HG, Lee BH, Kim W, Lee JS, Kim GH, Chun OK, Koo SI, Kim DO (2014) Lithospermum erythrorhizon extract protects keratinocytes and fibroblasts against oxidative stress. J Med Food 17:1189–1196
Yui S, Fujiwara S, Harada K, Motoike-Hamura M, Sakai M, Matsubara S, Miyazak K (2017) Beneficial effects of lemon balm leaf extract on in vitro glycation of proteins, arterial stiffness, and skin elasticity in healthy adults. JJ Nutr Sci Vitaminol 63:59–68
Zvereva EL, Kozlov MV (2006) Consequences of simultaneous elevation of carbon dioxide and temperature for plant-herbivore interactions: a meta analysis. Glob Chang Biol 12(1):27–41
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Khatri, S., Paramanya, A., Ali, A. (2019). Phenolic Acids and Their Health-Promoting Activity. In: Ozturk, M., Hakeem, K. (eds) Plant and Human Health, Volume 2. Springer, Cham. https://doi.org/10.1007/978-3-030-03344-6_27
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