Abstract
The skin and mucosal level of the immune system where most immune processes take place is described. The reader can find some new data concerning the tissue-specific homeostatic cytokines, which make cells of the immune system move in the certain skin and mucosal departments. This important topic is often absent in immunology manuals.
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Bibliography
Reviews
Aguilera Montilla N, Perez Blas M, Lopez Santalla M, Martin Villa JM. Mucosal immune system: a brief review. Inmunología. 2004;23(2):207–16.
Haniffa M, Gunawan M, Jardine L. Human skin dendritic cells in health and disease. J Dermatol Sci. 2015;77(2015):85–92. https://doi.org/10.1016/j.jdermsci.2014.08.012.
Iwasaki A, Foxman EF, Molony RD. Early local immune defences in the respiratory tract. Nat Rev Immunol. 2017;17:7–20. https://doi.org/10.1038/nrl.2016.117.
Kurashima Y, Kiyono H. New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development. Exp Mol Med. 2014;46:e83. https://doi.org/10.1038/emm.2014.7.
Ogra PL, Faden H, Welliver RC. Vaccination strategies for mucosal immune responses. Clin Microbiol Rev. 2001;14(2):430–45. https://doi.org/10.1128/CMR.14.2.430–445.2001.
Peterson LW, Artis D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol. 2014;14:141–53. https://doi.org/10.1038/nri3608.
Reboldi A, Cyster JG. Peyer's patches: organizing B-cell responses at the intestinal frontier. Immunol Rev. 2016;271(1):230–45. https://doi.org/10.1111/imr.12400.
Smolinska S, Jutel M, Crameri R, O’Mahony L. Histamine and gut mucosal immune regulation. Allergy. 2014;69:273–81. https://doi.org/10.1111/all.12330.
Weiner HL, da Cunha AP, Quintana F, Wu H. Oral tolerance. Immunol Rev. 2011;241:241–59. https://doi.org/10.1111/j.1600-065X.2011.01017.x.
Zawrotniak M, Kozik A, Rapala-Kozik M. Chapter 1. Neutrophil extracellular traps in infectious human diseases. In: Khajh M, editor. Role of neutrophils in disease pathogenesis, vol. 2017. London: InTech. p. 1–25. https://doi.org/10.5772/intechopen.68443.
Landmark Papers
Brandtzaeg P, Kiyono H, Pabst R, Russell MW. Terminology: nomenclature of mucosa-associated lymphoid tissue. Mucosal Immunol. 2008;1:31–7. https://doi.org/10.1038/mi.2007.9.
Mann ER, Smith KM, Bernardo D, Al-Hassi HO, Knight SC, Hart AL. Review: skin and the immune system. Clin Exp Dermatol Res. 2012;S2:1–16. https://doi.org/10.4172/2155-9554.S2-003.
Ruddle NH. Lymphatic vessels and tertiary lymphoid organs. J Clin Invest. 2014;124(3):953–9. https://doi.org/10.1172/JCI71611.
Suggested Reading
Anjue’re F, Bekri S, Bihl F, Braud VM, Cuburu N, Czerkinsky C, Hervouet C, Luci C. B cell and T cell immunity in the female genital tract: potential of distinct mucosal routes of vaccination and role of tissue-associated dendritic cells and natural killer cells. Clin Microbiol Infect. 2012;18(5):117–22. https://doi.org/10.1111/j.1469-0691.2012.03995.x.
Egawa G, Kabashima K. Skin as a peripheral lymphoid organ: revisiting the concept of skin-associated lymphoid tissues. J Investig Dermatol. 2011;131:2178–85. https://doi.org/10.1038/jid.2011.198.
Griffith JW, Sokol CL, Luster AD. Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annu Rev Immunol. 2014;32:659–702. https://doi.org/10.1146/annurev-immunol-032713-120145.
Kiyono H, Fukuyama S. NALT - versus Peyer’s-patch-mediated mucosal immunity. Nat Rev Immunol. 2004;4:699–710. https://doi.org/10.1038/nri1439.
Kotredes KP, Thomas B, Gamero AM. The protective role of type I interferon in the gastrointestinal tract. Front Immunol. 2017;8(410):1–24. https://doi.org/10.3389/fimmu.2017.00410.
McGovern N, Schlitzer A, Gunawan M, et al. Human dermal CD14+ cells are a transient population of monocyte-derived macrophages. Immunity. 2014;41(3):465–77. https://doi.org/10.1016/j.immuni.2014.08.006.
Rahnama M, Czupkałło Ł, Kozicka-Czupkałło M, Łobacz M. Gingival crevicular fluid – composition and clinical importance in gingivitis and periodontitis. Pol J Public Health. 2014;124(2):96–8. https://doi.org/10.2478/pjph-2014-0022.
Randall TD, Mebius RE. The development and function of mucosal lymphoid tissues: a balancing act with micro-organisms. Mucosal Immunol. 2014;7(3):455–66. https://doi.org/10.1038/mi.2014.11.
Rescigno M, Di Sabatino A. Dendritic cells in intestinal homeostasis and disease. J Clin Invest. 2009;119(9):2441–50. https://doi.org/10.1172/JCI39134.
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Klimov, V.V. (2019). Skin and Mucosal Immune System. In: From Basic to Clinical Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-03323-1_2
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DOI: https://doi.org/10.1007/978-3-030-03323-1_2
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