Insertion Related Infection Prevention with Vascular Access Devices
The goal of vascular access devices is to provide for the administration of the therapies required to help the patient recover while causing the least amount of damage to the patient’s vascular system. One of the ways to preserve patient vasculature is through the prevention of infections associated with these devices. The central line bundle, created by Peter Pronovost in a landmark study known as the keystone study in Michigan, consists of five components that, when strictly adhered to during the insertion of a central line catheter, are known to reduce the risk of catheter-related BSIs. The five components include hand hygiene, maximal barrier precautions during insertion, use of chlorhexidine as a skin antisepsis, optimal catheter site selection with avoidance of the femoral vein for central venous access in adult patients, and daily review of line necessity with prompt removal of unnecessary lines. These five components to prevent infection during the insertion of a central catheter are reviewed within this chapter. Care and maintenance considerations, equally important in the prevention of infection, are covered in detail throughout the rest of this book.
KeywordsCVAD infection prevention Central line bundle Personal protective equipment Site selection Device necessity
A monumental amount of attention has been devoted to preventing infections during the insertion phase of a vascular catheter’s life cycle. The very act of breaking the skin barrier and inserting a medical device directly through the vein wall and into the blood stream deserves special attention, as the patient’s natural infection prevention barriers have been disrupted. Defining key infection prevention elements during the insertion of a central catheter (known as the central line bundle) and monitoring adherence to these elements has resulted in tremendously positive results; knowledge of and adherence to these protocols has become a core expectation for all healthcare environments (APIC 2015; The Joint Commission 2012). Due to the positive impact sustained by adhering to the central line bundle, these core elements (hand hygiene, maximal barrier precautions during insertion, use of chlorhexidine as a skin antisepsis, optimal catheter site selection with avoidance of the femoral vein for central venous access in adult patients, daily review of line necessity with prompt removal of unnecessary lines) deserve further review and understanding.
10.2 Hand Hygiene
Since the days of Ignaz Semmelweis, hand hygiene has been a fundamental part of any infection prevention strategy (WHO 2009). Hand washing is the cornerstone to aseptic technique practiced by all medical professionals to decrease the risk of bacterial contamination and the transmission of microbes from patient to patient (PICC Excellence 2018).
With Soap and Water:
Wet hands with water.
Apply enough soap to cover all hand surfaces.
Rub hands palm to palm.
Rub right palm over left dorsum with fingers interlaced. Repeat on other side.
Rub hands palm to palm with fingers interlaced.
Rub back of fingers to opposing palms with fingers interlocked.
Perform rotational rubbing of left thumb clasped in right palm and vice versa.
Perform rotational rubbing, backward and forward, with clasped fingers of right hand in left palm and vice versa.
Rinse hands thoroughly under running water.
Use clean paper towel to dry hands. Do not wave hands or blow on skin to dry.
Turn off faucet using same paper towel.
Hand Rub Procedure (WHO 2015):
Apply a palm full of product in cupped hand and cover all surfaces.
Rub hands palm to palm.
Rub right palm over left dorsum with fingers interlaced and vice versa.
Rub hands palm to palm with fingers interlaced.
Rub backs of fingers to opposing palms with fingers interlocked.
Perform rotational rubbing of left thumb clasped in right palm and vice versa.
Perform rotational rubbing, backwards and forwards with clasped fingers of right hand in left palm and vice versa.
Allow to air-dry. Once dry, your hands are ready for your gloves.
Soap and water cleansing is still necessary after caring for patients who have Clostridium difficile as these spores are not susceptible to alcohol-based waterless cleansers (Gorski et al. 2016). Clostridium difficile has recently been renamed/reclassified as Clostridiodes difficile.
To protect the caregiver as well as the patient, gloves are used any time the hands will encounter blood or bodily fluids, or other potential pathogens, or when patients are on isolation precautions. Gloves are applied after hand hygiene has been performed, and hygiene is performed again following glove removal.
Handwashing requirements and recommendations per guidance publications
SHEA Compendium (Marschall et al. 2014)
• Perform hand hygiene prior to catheter insertion or manipulation
• Use an alcohol-based waterless product or antiseptic soap and water
• Use of gloves does not obviate hand hygiene
Guidelines for the Prevention of Intravascular Catheter-Related Infections (O’Grady et al. 2011a)
• Perform hand hygiene procedures, either by washing hands with conventional soap and water or with alcohol-based hand rubs (ABHR)
• Handwashing should be performed before and after palpating catheter insertion sites as well as before and after inserting, replacing, accessing, repairing, or dressing an intravascular catheter. Palpation of the insertion site should not be performed after the application of antiseptic, unless aseptic technique is maintained
EPIC3 (Loveday et al. 2014)
• Decontaminate hands and wear a new pair of clean non-sterile gloves before manipulating each patient’s catheter. Decontaminate hands immediately following the removal of gloves
• When decontaminating hands using an alcohol-based hand rub, hands should be free of dirt and organic material, and hand rub solution must come into contact with all surfaces of the hand; hands should be rubbed together vigorously, paying particular attention to the tips of the fingers, the thumbs, and the areas between the fingers, until the solution has evaporated, and the hands are dry
CDC Hand Hygiene Guidelines (2002) (Prevention 2002)
• When hands are visibly dirty or contaminated with proteinaceous material or are visibly soiled with blood or other body fluids, wash hands with either a non-antimicrobial soap and water or an antimicrobial soap and water
• If hands are not visibly soiled, use an alcohol-based hand rub or an antimicrobial soap and water for routinely decontaminating hands in all other clinical situations
• Decontaminate hands before donning sterile gloves when inserting a central intravascular catheter
• Decontaminate hands before inserting indwelling urinary catheters, peripheral vascular catheters, or other invasive devices that do not require a surgical procedure
• Decontaminate hands after removing gloves
INS Standards of Practice(Gorski et al. 2016)
• Perform hand hygiene with an alcohol-based hand rub or antimicrobial soap and water during patient care
– Before having direct contact with the patient
– Before donning sterile gloves when inserting a central intravascular catheter
– Before inserting a peripheral vascular catheter
– After contact with the patient’s intact or non-intact skin
– After contact with body fluids or excretions, mucous membranes, and wound dressings (if the hands are not visibly soiled)
– After contact with inanimate objects (including medical equipment) in the immediate vicinity of the patient
– After removing gloves
• Use an alcohol-based hand rub routinely when performing hand hygiene unless the hands are visibly soiled, or there is an outbreak of a spore-forming pathogen or norovirus gastroenteritis
WHO Five Moments for Hand Hygiene (WHO 2009)
• Wash hands only when visibly soiled; otherwise hand rub
• Hand rub before patient contact, before inserting catheters, after risk of exposure to bodily fluids, after patient contact, and after contact with patient surroundings
10.3 Maximal Barrier Precautions
Non-sterile caps and masks
Sterile large full-body drapes
The clinician wears the gown, cap, gloves, and mask to protect the patient from the clinician’s microorganisms, and the patient is covered in full-body drapes to protect the patient from having his own microorganisms or bed microorganisms move from non-treated areas into areas that have been cleaned in an aseptic manner.
10.3.1 Sterile Gown
The sterile gown is used as part of the insertion procedure to prevent the transfer of microbes from the clinician to the patient, reducing the risk of infection. The sterile gown, which should be donned prior to donning sterile gloves, is folded so that the clinician can don the gown in a manner that maintains sterility. The clinician slips hands through the armholes and moves the arms in an outward motion, being careful not to touch any non-sterile items in the area. The gown unfolds, covering the clinician’s arms and shoulders. An assistant can then grasp the strings and tie the gown behind the clinician’s neck. To avoid contamination of the sleeves, hands should not be put through the sleeves and out the open end of the gown; keep cuffs of gown well over hands. Once gown is on and tied, it is time to don the sterile gloves.
Gloves are required for all intravascular insertion procedures. According to the CDC and INS, sterile gloves are to be worn for the insertion of all arterial, central venous and midline catheters (Gorski et al. 2016; O’Grady et al. 2011a). Requirement for the use of sterile versus non-sterile gloves for peripheral intravenous catheter (PIVC) insertions is in a period of evolution. The CDC recommendations indicate that clean gloves for the insertion of PIVC, but sterile gloves if the site is re-palpated (O’Grady et al. 2011a). INS standards specify the use of a new pair of disposable, non-sterile gloves for peripheral intravenous insertions if Standard-ANTT is being used (no re-palpation of the site after asepsis) throughout the insertion procedure but suggests increased attention to aseptic technique and consideration of sterile gloves, as well as contamination concerns with the use of clean versus sterile gloves (Gorski et al. 2016).
10.3.3 How to Don Sterile Gloves
Open the sterile pack prior to donning gown so that the gloves can be accessed easily. The gloves are folded and cuffed exposing the inner glove so that the outer glove is not touched by the hand.
Grasp the cuff of one glove with the fingertips of the opposite hand which is still covered by the sterile gown sleeve. This way, only the sterile gown touches the sterile glove.
Slip hand into glove and pull the cuff over to unroll glove and cover hand and sleeve cuff.
Using the gloved hand, open the second glove from underneath the cuff allowing the sterile glove to touch the sterile portion of the second glove; slide second hand into glove and unfold to cover hand and sleeve cuff.
Important tips (PICC Excellence 2018):
Always overlap sterile gown with glove cuffs.
It is essential to avoid touching non-sterile items once sterile gloves are applied; the hands and fingers may be kept interlaced and in front of you at or above waist level to avoid inadvertent contamination.
When clean gloves are used there is also potential for contamination by touching environmental surfaces prior to handling insertion supplies. Change clean gloves immediately before an invasive procedure such as VAD insertion.
Refrain from adjusting the mask or scratching the nose once sterile gloves are in place.
Any break or tear in the sterile gloves or touching the sterile glove to a non-sterile surface requires immediate removal with gown cuffs pulled down and application of new sterile gloves.
Audits may be performed to not only assess the appropriate application and use of gloves but also provide a more careful review of glove usage including considerations such as maintaining sterility and changing gloves when contaminated.
10.3.4 Sterile Drapes
A full-body sterile drape is placed on the patient to minimize the movement of microorganisms into the site selected for the catheter insertion procedure and to prevent contamination of the catheter prior to insertion into the bloodstream by allowing it to touch only the sterile surface of the full-body drape. Once the sterile drape is positioned, it is not moved or rearranged. Keep in mind that once a patient is draped, only the top surface of the draped area is considered sterile. Areas where skin is exposed, such as with a fenestration, should be skin adherent to avoid contamination from un-prepped skin. Exposed skin, regardless of prepping, remains a source of contamination. Do not touch skin with gloved hands or with the catheter.
10.4 Patient Skin Preparation
Skin preparation using chlorhexidine is another step in the central line bundle known to reduce the risk of infection. Two distinct steps must be performed prior to penetrating the skin barrier for the insertion of a vascular access device: the skin at and near the insertion site must be cleaned of any visible soil, and the insertion site must be prepared with an antiseptic agent (Gorski et al. 2016).
Many clinicians choose to cleanse the skin with soap and water or a skin cleansing wipe or other product formulation (Garland et al. 1995). This may help reduce the bioburden and the risk of inactivation of the antimicrobial solution if proteinaceous materials are present. However, a large French study failed to identify a difference in infection rates when a detergent cleansing was added prior to application of the antiseptic agent (Mimoz et al. 2015).
Chlorhexidine bathing is effective in reducing the bioload on the body especially when the chlorhexidine is applied without rinsing. Routine bathing of patients with chlorhexidine results in reduction of CLABSI. Randomized trials, meta-analyses, and guideline recommendations provide a strong basis for this practice (Timsit et al. 2018).
10.5 Appropriate Skin Decontamination
Once the skin is cleaned, it is ready to be prepared with an antiseptic. While alcohol and betadine offer some antimicrobial benefit, chlorhexidine gluconate (CHG) has become the standard for skin preparation prior to IV insertions for patients greater than 2 months old. According to the label, CHG must be used with caution in children less than 2 months of age. Commercially available preparations of CHG are combined with alcohol to achieve rapid kill as well as persistence. Early studies strongly supported the use of CHG over povidone-iodine for skin preparations (Maki et al. 1994). The CDC recommends >0.5% chlorhexidine (CHG) with 70% alcohol as the antiseptic of choice (O’Grady et al. 2011a). A recent study by McCann et al. did not find a statistically significant improvement in CLABSI rates when increasing CHG to 2% in alcohol over more routinely used concentrations (McCann et al. 2016). While no agent can completely rid the skin of every microorganism, CHG is proven to be effective over the most common infecting microbes. Chlorhexidine is recommended both for its broad-spectrum action on bacteria, viruses, and fungi and its residual effect. CHG provides continual residual killing action for 48–72 h after application. Label claims vary per formulation, but at least one product now has a label claim for a 7-day kill which may offer some benefits (Healthcare 2017).
With all products, understanding appropriate use requires careful reading of instructions prior to use. Each comes with specific instructions regarding appropriate application method, duration of scrub time and necessary dry time based on volume of product used and anatomical location. Ensuring that products are applied appropriately is a significant consideration that likely does not receive enough attention during process monitoring (Casey et al. 2017).
In general, the widely available skin disinfection products in the US market promote a frictional back and forth method of application using pressure as described below (Silva 2014):
Apply antiseptic solution using a frictional back and forth motion until all applicator solution is used.
Allow antiseptic solution to air-dry (do not blow or blot dry).
Because chlorhexidine with alcohol dries much faster, it reduces the likelihood that the catheter will be inserted before bacteria have died. Regardless of the product selected, ensuring that the product has dried completely prior to application of the transparent dressing minimizes the risk of skin irritation.
When ultrasound is used as part of the insertion process, the device’s cleanliness and disinfection procedures need to be ascertained. For central and midline placement, the use of sterile gel and sterile probe cover during the insertion procedure is a standard practice. As with all medical equipment, cleaning and disinfection must follow manufacturer’s recommendations and accepted infection control standards. Delicate transducers may require products that are not routinely used in the organization. If non-sterile gel is used during the initial assessment, ensure that single use sterile packets are available for use during the insertion procedure. Ensure that maintenance of non-sterile versus sterile gels is consistent with recommended practices to reduce inadvertent contamination (Oleszkowicz et al. 2015).
The Association for Vascular Access (AVA) published Guidance on Transducer Disinfection that established the need to develop processes for transducer (probe) cleaning in conjunction with patient use, validation of clinician training, and use of commercially manufactured sheath for all patient-based activities that involve contact with blood/body fluids or non-intact skin, evaluate outcomes, and document performance and training (Association for Vascular Access 2018). Programs should also review recommendations for frequency of probe cable and unit disinfection beyond just the transducer, as contamination of these surfaces is also noted as a significant concern.
For ultrasound-guided PIVC insertion, clinicians have found success with varying levels of ANTT. Be aware of facility policies which dictate the frequency of cleaning the entire surfaces of equipment (not just the probe) particularly when caring for patients in isolation precautions. For the infection control considerations of this chapter, ultrasound may also have additional impact by decreasing the number of attempts necessary to gain access.
10.7 Site Selection
Risk consideration based on knowledge of skin flora concentrations (arm veins versus femoral)
Diagnosis (how long will the catheter be in use)
Therapy (what kind of infusions are required)
Vessel health and size (looking for straight, non-stenosed, bouncy, large veins)
Age of patient (infant vs. adult)
Length of time treatment required
Some areas of insertion, such as the neck or femoral area, are prone to higher infection rates than other sites (arm) due to high microbial counts, humidity, and difficulty in dressing adherence. These factors must be taken into consideration when selecting and disinfecting an insertion site. For example, the femoral site is generally avoided due to its heavy colonization; however, a more recent review article suggests that the risk of infection from this site may no longer be as disparate from other locations (Marik et al. 2012) as originally believed.
Tunneling a CVAD to an area of greater safety may improve outcomes as in the case of mid-thigh femoral vein insertion. Moving an insertion location from the groin, axilla, or neck onto the leg, mid-upper arm, or chest, respectively, improves the ability to maintain transparent dressing adherence, reduces contamination caused by dressing disruption, and moves the insertion location onto a more secure and stable platform.
When the internal jugular vein is selected, care must be given for optimal placement to allow for maintenance of an intact dressing, which may require updated insertion practices. An intact dressing provides an important barrier to microbial transmission. Understanding the importance of an intact dressing helps the inserter when considering various options for insertion site location.
The location of a PIVC can impact outcomes and failure rates. For peripheral devices, there has been much published in support of the use of the forearm as the preferred insertion site to promote longer dwell time; decrease pain, phlebitis, infiltration, and dislodgement; and facilitate patient self-care (Fields et al. 2012; Gorski et al. 2016; Wallis et al. 2014). Insertion in the forearm creates a stable location for securement and dressing. There are considerations for other locations and the ability to maintain an intact dressing such as present with devices located in the hand or antecubital fossa.
Careful assessment of specific anatomical characteristics along the vein path allows for planning of optimal needle insertion or exit site to minimize the risk related to ongoing care and maintenance of the device. This pre-insertion assessment should include an external visual inspection looking for optimal access sites (e.g., away from areas of flexion or skin irritation/compromise) and an internal inspection with use of ultrasound to determine vein path and health. The goal with any distal catheter tip placement is to maximize three factors.
10.8 Daily Review of Line Necessity
The most effective way to prevent catheter-related BSI is to simply not have a catheter. As basic as this sounds, it is paramount to infection prevention. As soon as the catheter is no longer medically necessary, it should be removed. While this is a recommendation by many healthcare groups and authors, establishing a policy and process with measured staff compliance for daily review is rare.
Is the catheter still necessary for treatment of this patient or just convenient (don’t retain for convenience such as periodic blood draws)?
Can the patient be switched to a peripheral IV or to oral medications?
Are there any catheter-related complications?
Are there alternative therapies that could be used that would allow for the removal of the line?
Is therapy completed or being discontinued?
Is the patient satisfied and comfortable with the current delivery of medications?
The goal of vascular access devices is to provide for the administration of the therapies required to help the patient recover while causing the least amount of damage to the patient’s vascular system. As soon as it is determined that the vascular access device is no longer medically necessary, it should be removed from the patient.
10.9 Use of Insertion Checklists and Observers
It is recommended that an observer be present during any central venous catheter (CVC) insertion procedure to ensure aseptic technique is maintained throughout the procedure (O’Grady et al. 2011a). The Society for Healthcare Epidemiology of America (SHEA) recommendations state, “CVC insertion should be observed by a nurse, physician or other healthcare personnel who has received appropriate education, is certified to perform the procedure and has received education in aseptic technique to ensure that aseptic technique is maintained” (Marschall et al. 2014). “This observer should be empowered to stop the procedure if breaches in aseptic technique are observed.” Following a checklist during a central vascular insertion procedure has such a profound effect on patient safety that in 2013, the Agency for Healthcare Research and Quality named “bundles that include checklists to prevent central line-associated bloodstream infection (CLABSI)” one of the top 10 “strongly encouraged patient safety practices” (Chopra et al. 2013).
The use of CLIP was introduced with the expectation that it would be completed by a trained observer (ideally empowered to stop the procedure in the event of a breach in sterile technique). There is some concern with the nursing insertion teams at times being staffed without the ability to have a trained observer. Expert consensus is that it is not ideal to assess one’s own compliance with Surgical-ANTT; expanding practice to allow a trained observer to be present is in the best interest of patient safety (of note, this need not be another vascular access nurse or even another registered nurse but can be accomplished by another staff member with adequate training). Work continues to be published evaluating the impact of care bundles and checklists as effective means to improve outcomes (Blot et al. 2014).
Clinical bundle modified (DeVries et al. 2016)
Components of protected clinical bundle
Chlorhexidine and alcohol skin prep
Provide adequate skin disinfection of bacteria on skin
Sterile gloves if re-palpation of skin
Aseptic non touch technique
Intravenous catheter with integrated
Reduces manipulation consistent with INS standards
Indicated to reduce skininfections, skin colonization and bloodstream infection
Securement is strong element in preventing catheter movement
Alcohol disinfection caps
Provide intraluminal protection
A regional teaching hospital identified a rising rate of central line-associated bloodstream infections and wanted to verify the medical and nursing staff understood and applied the foundational principles of infection prevention to their insertion and maintenance practices with CVADs. Most of the infections were occurring in the early days following insertion, so the main emphasis was on insertion-related considerations.
A vascular access infection prevention committee was formed. The committee identified the foundational practices, standards, and guidelines from the Centers for Disease Control (CDC), Evidence-based Practices in Infection Control (EPIC), Society of Healthcare Epidemiology of America (SHEA), and others. They incorporated education on the central line bundle and checklist, evidence-based maintenance practices for aseptic technique, and prepared an evaluation tool for staff observation. A two-step process included education and observation to verify understanding of the foundational principles. Following the completion of the education, based on data collected during observation, it was decided that the central line bundle checklist required an independent observer to verify the steps. After analyzing the temporal association with this intervention with decreased early-onset infections, the committee determined the integration of the observer would provide a long-term solution for CVAD insertion infection prevention compliance in this teaching facility.
Due to the nature of changing medical staff and attrition among nursing staff, the committee was later deemed a permanent committee and went on to establish other methods to standardize infection prevention practices with all vascular access insertion and management at the hospital.
Summary of Key Points
The prevention of catheter-related BSIs is paramount to the preservation of vessel health.
Adhering to the components of the central line bundle during a central line insertion procedure has proven to be an effective way to prevent catheter-related BSIs.
- 3.The five components of the central line bundle include:
Maximal barrier precautions during insertion
Use of chlorhexidine as a skin antisepsis
Optimal catheter site selection with avoidance of the femoral vein for central venous access in adult patients
Daily review of catheter necessity with prompt removal of unnecessary catheters
As an infection prevention strategy, catheters should be removed as soon as they are deemed no longer medically necessary.
It is recommended that an observer be present during any central venous catheter (CVC) insertion procedure to ensure ANTT is maintained throughout the procedure.
The use of a checklist to prevent central line-associated bloodstream infection is one of the top 10 “strongly encouraged patient safety practices.”
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