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Congenital Hyperinsulinism pp 85–93Cite as

18F-DOPA PET

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Part of the book series: Contemporary Endocrinology ((COE))

Abstract

One of the main goals in the evaluation of congenital hyperinsulinism is to distinguish medically treatable disease from disease requiring surgical management. Over the past 20 years, it has become clear that some patients with severe disease that is unresponsive to medical therapy may benefit from pancreatectomy. One of the big challenges has been distinguishing between two histopathologic forms of HI, diffuse disease, which is not curable, and focal disease, which can be cured with limited pancreatic resection. Diagnostic evaluation with the 18-F-L-3,4-dihydroxyphenylalanine [18F]-DOPA PET scan has been shown to have moderate-good sensitivity for diagnosis of a focal lesion but almost 100% accuracy in localizing a detected lesion. The finding of a focal lesion can change surgical approach, decrease surgical morbidity, and lead to a cure of this devastating disease.

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Author information

Authors and Affiliations

  1. Department of Radiology, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Lisa J. States

  2. Otto-von-Guericke Universität, Universitätskinderklinik, Magdeburg, Germany

    Klaus Mohnike

Authors
  1. Lisa J. States
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  2. Klaus Mohnike
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Correspondence to Lisa J. States .

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Editors and Affiliations

  1. Division of Endocrinology and Diabetes, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania and The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Diva D. De León-Crutchlow

  2. Division of Endocrinology and Diabetes, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania and The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Charles A. Stanley

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States, L.J., Mohnike, K. (2019). 18F-DOPA PET. In: De León-Crutchlow, D., Stanley, C. (eds) Congenital Hyperinsulinism. Contemporary Endocrinology. Humana Press, Cham. https://doi.org/10.1007/978-3-030-02961-6_7

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  • DOI: https://doi.org/10.1007/978-3-030-02961-6_7

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  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-030-02960-9

  • Online ISBN: 978-3-030-02961-6

  • eBook Packages: MedicineMedicine (R0)

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