Abstract
Worldwide, cervical cancer is the fourth most common cancer among women, with an estimated 528,000 new cases (7.9% of cancer in women) and 266,000 deaths (7.5% of cancer deaths in women) in the year 2012 and a 5-year prevalence of 1.5 million cases (9% of women with cancer). About 85% of the cases occur in developing countries, where cervical cancer accounts for 12% of all cancers in women. The cervical and endometrial cancers originate in the uterus but differ drastically in terms of aetiology, clinical presentation and characteristics, prognosis and survival. Cervical cancer is a model of viral carcinogenesis and most common in developing countries, whereas endometrial cancer is a model of hormonal carcinogenesis and most common in developed countries. The aim of this chapter is to provide an overview of key concepts in cancer epidemiology and to describe the global patterns and trends in incidence and mortality, aetiology and prevention of cervical cancer.
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References
Memon A. Epidemiological understanding: an overview of basic concepts and study designs. In: Pencheon D, et al., editors. Oxford handbook of public health practice. 2nd ed. Oxford: Oxford University Press; 2006. p. 100–11.
Memon A. Epidemiology of gynaecological cancers. In: Shafi M, et al., editors. Gynaecological oncology. Cambridge: Cambridge University Press; 2010. p. 1–13.
Forman D, Bray F, Vrewster D, et al. Cancer incidence in five continents, Vol X (electronic version) Lyon, IARC. 2013. Available from: http://ci5.iarc.fr/CI5-X
Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr
The Surveillance, Epidemiology, and End Results (SEER) Program. Available from: http://seer.cancer.gov
National Cancer Institute. Cervical cancer. 2014. Available from: http://www.cancer.gov/cancertopics/types/cervical
Centers for Disease Control and Prevention (CDC), National Programme of Cancer Registries (NPCR). Available from: http://apps.nccd.cdc.gov/uscs and http://www.cdc.gov/cancer/npcr
Ryerson A, Eheman C, Altekruse S, et al. Annual report to the nation on the status of cancer, 1975–2012, featuring the increasing incidence of liver cancer. Cancer. 2016;122(9):1312–37.
Ylitalo N, Stuver S, Adami H. Cervical cancer. In: Hans-Olov A, et al., editors. Textbook of cancer epidemiology. 2nd ed. New York: Oxford University Press; 2008. p. 446–67.
Cancer Research UK. Available from: http://info.cancerresearchuk.org
Schiffman M, Castle P, Jeronimo J, et al. Human papillomavirus and cervical cancer. Lancet. 2007;370(9590):890–907.
Castle P, Rodriguez A, Burk R, et al. Short term persistence of human papillomavirus and risk of cervical precancer and cancer: population based cohort study. BMJ. 2009;339:b2569.
Crosbie E, Einstein M, Franceschi S, et al. Human papillomavirus and cervical cancer. Lancet. 2013;382(9895):889–99.
Guan P, Howell-Jones R, Li N, et al. Human papillomavirus types in 115,789 HPV-positive women: a meta-analysis from cervical infection to cancer. Int J Cancer. 2012;131(10):2349–59.
Li N, Franceschi S, Howell-Jones R, et al. Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: variation by geographical region, histological type and year of publication. Int J Cancer. 2011;128(4):927–35.
Cox J. The development of cervical cancer and its precursors: what is the role of human papillomavirus infection? Curr Opin Obstet Gynecol. 2006;18(suppl.1):S5–S13.
Sellors J, Karwalajtys T, Kaczorowski J, et al. Incidence, clearance and predictors of human papillomavirus infection in women. CMAJ. 2003;168(4):421–5.
Dunne E, Unger E, Stenberg M, et al. Prevalence of HPV infection among females in the United States. JAMA. 2007;297(8):813–9.
Plummer M, de Martel C, Vignat J, et al. Global burden of cancers attributable to infections in 2012: a synthetic analysis. Lancet Glob Health. 2016;4(9):609–16.
Franceschi S, Herrero R, Clifford G, et al. Variations in the age-specific curves of human papillomavirus prevalence in women worldwide. Int J Cancer. 2006;119(11):2677–84.
De Sanjose S, Diaz M, Castellsague X, et al. Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis. 2007;7(7):453–9.
International Collaboration of Epidemiological Studies of Cervical Cancer. Carcinoma of the cervix and tobacco smoking: collaborative reanalysis of individual data on 13,541 women with carcinoma of the cervix and 23,017 women without carcinoma of the cervix from 23 epidemiological studies. Int J Cancer. 2006; 118 6 :1481–95.
Kapeu A, Luostarinen T, Jellum E, et al. Is smoking an independent risk factor for invasive cervical cancer? A nested case-control study within Nordic biobanks. Am J Epidemiol. 2008;169(4):480–8.
Plummer M, Herrero R, Franceschi S, et al. Smoking and cervical cancer: pooled analysis of the IARC multi-centric case-control study. Cancer Causes Control. 2003;14(9):805–14.
Schiffman M, Brinton L. The epidemiology of cervical carcinogenesis. Cancer. 1995;76(suppl.10):1888–901.
Palefsky J, Holly E. Molecular virology and epidemiology of human papillomavirus and cervical cancer. Cancer Epidemiol Biomark Prev. 1995;4(4):415–28.
Burger M, Hollema H, Gouw A, et al. Cigarette smoking and human papillomavirus in patients with reported cervical cytological abnormality. BMJ. 1993;306(6880):749–52.
International Agency for Research on Cancer. Human papillomavirus. IARC monographs. 2012; 100b:255–313.
De Vuyst H, Gichangi P, Estambale B, et al. Human papillomavirus types in women with invasive cervical carcinoma by HIV status in Kenya. Int J Cancer. 2008;122(1):244–6.
Sun X, Kuhn L, Ellerbrock T, et al. Human papillomavirus infection in women infected with the human immunodeficiency virus. N Engl J Med. 1997;337(19):1343–9.
Rohner E, Sengayi M, Goeieman B, et al. Cervical cancer risk and impact of pap-based screening in HIV-positive women on antiretroviral therapy in Johannesburg, South Africa. Int J Cancer. 2017;141(3):488–96.
Strickler H, Palefsky J, Shah K, et al. Human papillomavirus type 16 and immune status in human immunodeficiency virus-seropositive women. J Natl Cancer Inst. 2003;95(14):1062–71.
Dahlstrom L, Andersson K, Luostarinen T, et al. Prospective seroepidemiologic study of human papillomavirus and other risk factors in cervical cancer. Cancer Epidemiol Biomark Prev. 2011;20(12):2541–50.
Smith J, Bosetti C, Munoz N, et al. Chlamydia trachomatis and invasive cervical cancer: a pooled analysis of the IARC multicentric case-control study. Int J Cancer. 2004;111(3):431–9.
Smith J, Munoz N, Herrero R, et al. Evidence for chlamydia trachomatis as a human papillomavirus cofactor in the etiology of invasive cervical cancer in Brazil and the Philippines. J Infect Dis. 2002;185m(3):324–31.
Wallin K, Wiklund F, Luostarinen T, et al. A population-based prospective study of chlamydia trachomatis infection and cervical carcinoma. Int J Cancer. 2002;101(4):371–4.
Koskela P, Anttila T, Bjorge T, et al. Chlamydia trachomatis infection as a risk factor for invasive cervical cancer. Int J Cancer. 2000;85(1):35–9.
Munoz N, Franceschi S, Bosetti C, et al. Role of parity and human papillomavirus in cervical cancer: the IARC multicentric case-control study. Lancet. 2002;359(9312):1093–101.
Silins I, Ryd W, Strand A, et al. Chlamydia trachomatis infection and persistence of human papillomavirus. Int J Cancer. 2005;116(1):110–5.
Winer R, Hughes J, Feng Q, et al. Condom use and the risk of genital human papillomavirus infection in young women. N Engl J Med. 2006;354(25):2645–54.
Ursin G, Pike M, Preston-Martin S, et al. Sexual, reproductive and other risk factors for adenocarcinoma of the cervix: results from a population-based case-control study (California, United States). Cancer Causes Control. 1996;7(3):391–401.
Lee J, So K, Piyathilake C, et al. Mild obesity, physical activity, calorie intake, and the risks of cervical intraepithelial neoplasia and cervical cancer. PLoS One. 2013;8(6):e66555.
Garcia-Closas R, Castellsague X, Bosch X, et al. The role of diet and nutrition in cervical carcinogenesis: a review of recent evidence. Int J Cancer. 2005;117(4):629–37.
Peirson L, Fitzpatrick-Lewis D, Ciliska D, et al. Screening for cervical cancer: a systematic review and meta-analysis. Syst Rev. 2013;2:35.
NHS Choices. Available from: http://www.nhs.uk/pages/home.aspx
Landy R, Pesola F, Castanon A, et al. Impact of cervical screening on cervical cancer mortality: estimation using stage-specific results from a nested case-control study. Br J Cancer. 2016;115(9):1140–6.
Leeman A, del Pino M, Molijn A, et al. HPV testing in first-void urine provides sensitivity for CIN2+detection comparable with a smear taken by a clinician or a brush-based self-sample: cross-sectional data from a triage population. BJOG. 2017;124(9):1356–63.
Blake D, Crosbie E, Kitson S. Urinary HPV testing may offer hope for cervical screening non-attenders. BJOG. 2017;124(9):1364.
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Memon, A., Bannister, P. (2019). Epidemiology of Cervical Cancer. In: Farghaly, S. (eds) Uterine Cervical Cancer. Springer, Cham. https://doi.org/10.1007/978-3-030-02701-8_1
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DOI: https://doi.org/10.1007/978-3-030-02701-8_1
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