Skip to main content

Medicinal Mushrooms: Cultivation and Pharmaceutical Impact

  • Chapter
  • First Online:
Biology of Macrofungi

Part of the book series: Fungal Biology ((FUNGBIO))

Abstract

Mushroom cultivation for medicinal use marks a milestone that the society has moved into an era where mushrooms are no longer perceived as mere food that enhance the experience of satiety but edibles with valuable medicinal properties to wage against modern lifestyle diseases. The complex mushroom properties coupled with high cost to synthesize them artificially allow improved, fresh and creative ways of cultivation to expand. The cultivation rescues several rare medicinal species from extinction in the wild, reduce the impact of over harvest, exempt from heavy metal contamination and reduce the difficulty in terms of supply to meet demands. Yet, like cultivating mushrooms for food, unattainable cultivating procedures and etiquettes will cripple any potential chances of any mushroom properties to be developed as pharmaceuticals. Cultivating mushroom for its pharmaceutical properties demands different sets of quality control to ascertain the yield is safe, high in bioactive constituents and will deliver the expected bioactivities when consumed. Though the cultivation techniques for specific medicinal properties of mushrooms are still at infantry, the prospect is growing rapidly. The modern society will soon need the involvement of respective health authorities to enforce lawful manufacturing processes and guidelines. Mushroom pharmaceuticals are a not-too-distant future reality.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abdullah N, Haimi MZD, Lau BF, Annuar MSM (2013) Domestication of a wild medicinal sclerotial mushroom, Lignosus rhinocerotis (Cooke) Ryvarden. Ind Crop Prod 47:256–261

    Article  Google Scholar 

  • Adotey G, Quarcoo A, Holliday JC, Fofie S, Saaka B (2011) Effect of immunomodulating and antiviral agent of medicinal mushrooms (immune assist 24/7 TM) on CD4+ T-lymphocyte counts of HIV-infected patients. Int J Med Mushrooms 13(2):109–113

    Article  PubMed  Google Scholar 

  • Baral B, Shrestha B, da Silva JAT (2015) A review of Chinese Cordyceps with special reference to Nepal, focusing on conservation

    Google Scholar 

  • Barneche S, Alborés S, Borthagaray G, Cerdeiras MP, Vázquez A (2017) Anti-MRSA activity of fruiting body extracts of spectacular Rustgill mushroom, Gymnopilus junonius (Agaricomycetes). Int J Med Mushrooms 19(3):243–248

    Article  PubMed  Google Scholar 

  • Berlant SR (2005) The entheomycological origin of Egyptian crowns and the esoteric underpinnings of Egyptian religion. J Ethnopharmacol 102(2):275–288

    Article  PubMed  Google Scholar 

  • Capasso L (1998) 5300 years ago, the ice man used natural laxatives and antibiotics. Lancet 352(9143):1864

    Article  CAS  PubMed  Google Scholar 

  • Carhart-Harris RL, Roseman L, Bolstridge M, Demetriou L, Pannekoek JN, Wall MB (2017) Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. Sci Rep 7(1):13187

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chaiyasut C, Kruatama C, Sirilun S (2010) Breaking the spores of Ganoderma lucidum by fermentation with Lactobacillus plantarum. Afric J Biotechnol 9(43):7379–7382

    CAS  Google Scholar 

  • Chang ST (1980) Mushrooms as human food. BioSci 30(6):399–401

    Article  CAS  Google Scholar 

  • Chang ST (2008) Overview of mushroom cultivation and utilization as functional foods. In: Cheung PCK (ed) Mushrooms as functional foods. Wiley, Hoboken, pp 1–33

    Chapter  Google Scholar 

  • Chang ST, Hayes WA (2013) The biology and cultivation of edible mushrooms. Elsevier Science, Saint Louis, p 2013

    Google Scholar 

  • Chen J-T, Tominaga K, Sato Y, Anzai H, Matsuoka R (2010) Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Complement Med 16(12):1295–1299

    Article  CAS  PubMed  Google Scholar 

  • Chen P, Yong Y, Gu Y, Wang Z, Zhang S, Lu L (2015) Comparison of antioxidant and antiproliferation activities of polysaccharides from eight species of medicinal mushrooms. Int J Med Mushrooms 17(3):287–295

    Article  PubMed  Google Scholar 

  • Chen Y-S, Liu B-L, Chang YN (2011) Effects of light and heavy metals on Cordyceps militaris fruit body growth in rice grain-based cultivation. Korean J Chem Eng 28(3):875–879

    Article  CAS  Google Scholar 

  • Cheung PCK (2008) Mushrooms as functional foods: Wiley, ISBN 978–0–470-05406-2

    Google Scholar 

  • Cui M-L, Yang HY, He GQ (2015) Submerged fermentation production and characterization of intracellular triterpenoids from Ganoderma lucidum using HPLC-ESI-MS. J Zhejiang Univ Sci B 16(12):998–1010

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Daba A, Ezeronye O (2003) Anti-cancer effect of polysaccharides isolated from higher basidiomycetes mushrooms. Afr J Biotechnol 2(12):672–678

    Article  Google Scholar 

  • Das S, Masuda M, Hatashita M, Sakurai A, Sakakibara M (2008) A new approach for improving cordycepin productivity in surface liquid culture of Cordyceps militaris using high-energy ion beam irradiation. Lett Appl Microbiol 47(6):534–538

    Article  CAS  PubMed  Google Scholar 

  • Eik L-F, Naidu M, David P, Wong KH, Tan YS, Sabaratnam V (2012) Lignosus rhinocerus (Cooke) Ryvarden: a medicinal mushroom that stimulates neurite outgrowth in PC-12 cells. Evid-Based Complementary Altern Med 2012(1):7

    Google Scholar 

  • Evelyn J, De la Bédoyère G (2004) The diary of John Evelyn. Boydell Press

    Google Scholar 

  • Fabing HD (1956) On going berserk: a neurochemical inquiry. Am J of Psychiatry 113(5):409–415

    Article  CAS  Google Scholar 

  • Fang QH, Zhong JJ (2002) Submerged fermentation of higher fungus Ganoderma lucidum for production of valuable bioactive metabolites—ganoderic acid and polysaccharide. Biochem Eng J 10(1):61–65

    Article  CAS  Google Scholar 

  • Friedman M (2016) Mushroom polysaccharides: chemistry and antiobesity, antidiabetes, anticancer, and antibiotic properties in cells, rodents, and humans. Foods 5(4):80

    Article  PubMed Central  CAS  Google Scholar 

  • Fung SY, Cheong PCH, Tan NH, Ng ST, Tan CS (2018) Nutrient and chemical analysis of the fruiting body of a cultivar of the Chinese caterpillar mushroom, Ophiocordyceps sinensis (Ascomycetes). Int J Med Mush 20(5):459–469

    Article  Google Scholar 

  • Fung SY, Tan CS (2017) The bioactivity of Tiger Milk mushroom: Malaysia’s prized medicinal mushroom. In: Medicinal plants and fungi: Recent advances in research and development. Springer, Singapore, pp 111–133

    Chapter  Google Scholar 

  • Geng P, Siu KC, Wang Z, Wu JY (2017) Antifatigue functions and mechanisms of edible and medicinal mushrooms. Biomed Res Int 2017:1–16. https://doi.org/10.1155/2017/9648496

    Article  CAS  Google Scholar 

  • Gunde-Cimerman N, Cimerman A (1995) Pleurotus fruiting bodies contain the inhibitor of 3-Hydroxy-3-Methylglutaryl-coenzyme a reductase—lovastatin. Exp Mycol 19(1):1–6

    Article  CAS  PubMed  Google Scholar 

  • Hetland G, Johnson E, Lyberg T, Kvalheim G (2011) The mushroom Agaricus blazei Murill elicits medicinal effects on tumor, infection, allergy and inflammation through its modulation of innate immunity and amelioration of Th1/Th2 imbalance and inflammation. Adv Pharmacol Sci 2011:157015

    PubMed  PubMed Central  Google Scholar 

  • Huang N (1999) A new species of medicinal mushroom-cultivation of Hurulingzhi. Edible fungi China 18:8–9

    Google Scholar 

  • Huang Y, Lu J, Zhu B, Wen Q, Jia F, Zeng S (1987) Prevention and improvement of adrenal glands and thymus hormones, and infertile sperm count improve by 300% after Cordyceps supplement. Zhong Cheng Yao Yan Jiu 10:24–25

    Google Scholar 

  • Hueber FM (2001) Rotted wood–alga–fungus: the history and life of Prototaxites Dawson 1859. Rev Palaeobot Palynol 116(1–2):123–158

    Article  Google Scholar 

  • Hwang BS, Lee IK, Choi HJ, Yun BS (2015) Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii. Bioorganic Med Chem Lett 25(16):3256–3260

    Article  CAS  Google Scholar 

  • Jiraungkoorskul K, Jiraungkoorskul W (2016) Review of naturopathy of medicinal mushroom, Ophiocordyceps sinensis, in sexual dysfunction. Pharmacogn Rev 10(19):1–5

    Article  PubMed  PubMed Central  Google Scholar 

  • Jones K (1998) Reishi mushroom. Alt Complement Ther 4(4):256–266

    Article  Google Scholar 

  • Jose Alves M, CFR Ferreira I, Dias J, Teixeira V, Martins A, Pintado M (2013) A review on antifungal activity of mushroom (basidiomycetes) extracts and isolated compounds. Curr Top Med Chem 13(21):2648–2659

    Article  CAS  Google Scholar 

  • Katoh R, Ooshiro M (2007) Enhancement of antitumor effect of tegafur/uracil (UFT) plus leucovorin by combined treatment with protein-bound polysaccharide, PSK, in mouse models. Cell Mol Immunol 4:295-299

    Google Scholar 

  • Kim GY, Kim SH, Hwang SY, Kim HY, Park YM, Park SK, Lee MK, Lee SH, Lee TH, Lee JD (2003) Oral administration of proteoglycan isolated from Phellinus linteus in the prevention and treatment of collagen-induced arthritis in mice. Biol Pharm Bull 26(6):823–831

    Article  PubMed  Google Scholar 

  • Kim S-Y, Shrestha B, Sung GH, Han SK, Sung JM (2010) Optimum conditions for artificial fruiting body formation of Cordyceps cardinalis. Mycobiol 38(2):133–136

    Article  CAS  Google Scholar 

  • Kinoshita J, Fushida S, Harada S, Makino I, Nakamura K, Oyama K, Fujita H, Ninomiya I, Fujimura T, Kayahara M, Ohta T (2010) PSK enhances the efficacy of docetaxel in human gastric cancer cells through inhibition of nuclear factor-κB activation and survivin expression. Int J Oncol 36(3):593–600

    Article  CAS  PubMed  Google Scholar 

  • Kong B, Tan N, Fung S, Pailoor J, Tan C, Ng S (2016) Nutritional composition, antioxidant properties, and toxicology evaluation of the sclerotium of Tiger Milk mushroom Lignosus tigris cultivar E. Nut Res 36(2):174–183

    Article  CAS  Google Scholar 

  • Kozarski M, Klaus A, Jakovljevic D, Todorovic N, Vunduk J, Petrović P, Niksic M, Vrvic MM, Van Griensven L (2015) Antioxidants of edible mushrooms. Molecules 20(10):19489–19525

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lam W, Wang C, Tsui T, Wai M, Tang H, Wong Y (2012) Extract of white button mushroom affects skin healing and angiogenesis. Microsc Res Tech 75(10):1334–1340

    Article  CAS  PubMed  Google Scholar 

  • Lau BF, Abdullah N, Aminudin N, Lee HB, Tan PJ (2015) Ethnomedicinal uses, pharmacological activities, and cultivation of Lignosus spp. (Tiger Milk Mushrooms) in Malaysia–a review. J Ethnopharmacol 169:441–458

    Article  CAS  PubMed  Google Scholar 

  • Lau BF, Abdullah N, Aminudin N, Lee HB, Yap KC, Sabaratnam V (2014) The potential of mycelium and culture broth of Lignosus rhinocerotis as substitutes for the naturally occurring sclerotium with regard to antioxidant capacity, cytotoxic effect, and low-molecular-weight chemical constituents. PLoS One 9(7):e102509

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lee ML, Tan NH, Fung SY, Tan CS, Ng ST (2012) The antiproliferative activity of sclerotia of Lignosus rhinocerus (Tiger Milk Mushroom). Evid Based Complement Alternat Med 2012: Article ID697603

    Google Scholar 

  • Lee SS, Chang YS, Noraswati MNR (2009) Utilization of macrofungi by some indigenous communities for food and medicine in peninsular Malaysia. Forest Ecol Manag 257(10):2062–2065

    Article  Google Scholar 

  • Lee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, Lee KC, Lee LY, Chen WP, Chen CC, Huang WS, Kuo HC (2014a) Protective effects of Hericium erinaceus mycelium and its isolated Erinacine A against Ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci 15(9):15073–15089

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee SS, Tan NH, Fung SY, Sim SM, Tan CS, Ng ST (2014b) Anti-inflammatory effect of the sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden, the Tiger Milk mushroom. BMC Complement Altern Med 14(1):359

    Article  PubMed  PubMed Central  Google Scholar 

  • Lefevre CK, Hall IR (2001) The status of truffle cultivation: a global perspective. International Society for Horticultural Science (ISHS), Leuven

    Google Scholar 

  • Lemieszek M, Rzeski W (2012) Anticancer properties of polysaccharides isolated from fungi of the Basidiomycetes class. Contemp Oncol 16(4):285–289

    CAS  Google Scholar 

  • Li S, Dong C, Ha W, Liu X (2016) Development of Ling-zhi industry in China – emanated from the artificial cultivation in the Institute of Microbiology, Chinese Academy of Sciences (IMCAS). Mycology 7(2):74–80

    Article  PubMed  PubMed Central  Google Scholar 

  • Lin WH, Tsai MT, Chen YS, Hou RCW, Hung HF, Li CH, Wang HK, Lai MN, Jeng KCG (2007) Improvement of sperm production in subfertile boars by Cordyceps militaris supplement. Am J Chi Med 35(04):631–641

    Article  Google Scholar 

  • Liu YW, Gao JL, Guan J, Qian ZM, Feng K, Li SP (2009) Evaluation of antiproliferative activities and action mechanisms of extracts from two species of Ganoderma on tumor cell lines. J Agric Food Chem 57:3087–3093

    Article  CAS  PubMed  Google Scholar 

  • Lo TCT, Chang CA, Chiu KH, Tsay PK, Jen JF (2013) Correlation evaluation of antioxidant properties on the monosaccharide components and glycosyl linkages of polysaccharide with different measuring methods. Carbohydrate Poly 86:320–327

    Article  CAS  Google Scholar 

  • Lull C, Wichers HJ, Savelkoul HFJ (2005) Antiinflammatory and immunomodulating properties of fungal metabolites. Mediat Inflamm 2005(2):63–80

    Article  Google Scholar 

  • Ma B-J, Shen J-W, Yu H-Y, Ruan Y, Wu T-T, Zhao X (2010) Hericenones and erinacines: stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus. Mycol 1(2):92–98

    Article  CAS  Google Scholar 

  • Markova N, Kussovski V, Drandarska I, Nikolaeva S, Georgieva N, Radoucheva T (2003) Protective activity of Lentinan in experimental tuberculosis. Int Immunopharmacol 3(10–11):1557–1562

    Article  CAS  PubMed  Google Scholar 

  • Marley G (2009) Mushrooms for health: Medicinal secrets of Northeastern fungi: Down East, ISBN-13: 9780892728084

    Google Scholar 

  • McCall O (2018) Medicinal mushroom: A top food trend in 2018. Retrieved from https://born2invest.com/articles/medicinal-mushroom-top-food-trend-2018/

  • Michael PB, Alyssa AF, Jessica AP, Claire EW, Barbosa PCR, Rick JS (2015) Psilocybin-assisted treatment for alcohol dependence: a proof-of-concept study. J Psychopharmacol 29(3):289–299

    Article  CAS  Google Scholar 

  • Misachi J. The world’s top producers of mushroom and truffle 2017. Available from: https://www.worldatlas.com/articles/the-world-s-top-producers-of-mushroom-and-truffle.html

    Google Scholar 

  • Mizuno M, Ki M, Ito H, Kawade M, Terai H, Tsuchida H (1999) Anti-tumor polysaccharide from the mycelium of liquid-cultured Agaricus blazei mill. IUBMB Life 47(4):707–714

    Article  CAS  Google Scholar 

  • Mohanarji S, Dharmalingam S, Kalusalingam A (2012) Screening of Lignosus rhinocerus extracts as antimicrobial agents against selected human pathogens. J Pharm Biomed Sci 18(11):1–4

    Google Scholar 

  • Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T (2009) Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res 23(3):367–372

    Article  CAS  PubMed  Google Scholar 

  • Narsing Rao MP, Xiao M, Li W-J (2017) Fungal and bacterial pigments: secondary metabolites with wide applications. Front Microbiol 8:1113

    Article  PubMed  PubMed Central  Google Scholar 

  • Ng TB, Wang HX (2005) Pharmacological actions of Cordyceps, a prized folk medicine. J Pharm Pharmacol 57(12):1509–1519

    Article  CAS  PubMed  Google Scholar 

  • Patel S, Goyal A (2012) Recent developments in mushrooms as anti-cancer therapeutics: a review. 3 Biotech 2(1):1–15

    Article  PubMed  Google Scholar 

  • Petre M, Teodorescu A (eds) (2011) Medicinal mushrooms cultivation through the solid-state and submerged fermentations of agricultural wastes

    Google Scholar 

  • Phan C-W, David P, Naidu M, Wong K-H, Sabaratnam V (2015) Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Crit Rev Biotechnol 35(3):355–368

    Article  PubMed  CAS  Google Scholar 

  • Pitman JL, McGill JJ, Keegan KP, Allada R (2006) A dynamic role for the mushroom bodies in promoting sleep in Drosophila. Nature 441(7094):753–756

    Article  CAS  PubMed  Google Scholar 

  • Poucheret P, Fons F, Rapior S (2006) Biological and pharmacological activity of higher fungi: 20-year retrospective analysis. Cryptogam Mycol 27:311–333

    Google Scholar 

  • Pushparajah V, Fatima A, Chong CH, Gambule TZ, Chan CJ, Ng ST (2016) Characterisation of a new fungal immunomodulatory protein from Tiger Milk mushroom, Lignosus rhinocerotis. Sci Rep 6:30010

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rahman NA, Daud F, Kalil MS, Ahmad S (2012) Tiger milk mushroom cultivation by using submerged culture technique. WSEAS Trans Biol Biomed 3(9):83–92

    Google Scholar 

  • Reddy S (2015) Diversity and applications of mushrooms. In: Plant biol Biotechnol. Springer, New Delhi, pp 231–261

    Chapter  Google Scholar 

  • Reis FS, Martins A, Vasconcelos MH, Morales P, Ferreira ICFR (2017) Functional foods based on extracts or compounds derived from mushrooms. Trends Food Sci Technol 66:48–62

    Article  CAS  Google Scholar 

  • Royse D, Baars JJP, Tan Q (2017) In: Zied DC, Pardo-Gim ÃA (eds) Current overview of mushroom production in the world: technology and applications. Wiley, pp 5–13

    Google Scholar 

  • Ruck C (2011) Mushrooms, myth and Mithras: the drug cult that civilized Europe. City Lights Publishers, San Francisco

    Google Scholar 

  • Sabaratnam V, Kah-Hui W, Naidu M, David PR (2013) Neuronal health–can culinary and medicinal mushrooms help? J Tradit Complement Med 3(1):62–68

    Article  PubMed  PubMed Central  Google Scholar 

  • Schultz C (2013) Long before trees overtook the land, earth was covered by giant mushrooms. https://www.smithsonianmag.com/smart-news/long-before-trees-overtook-the-land-earth-was-covered-by-giant-mushrooms-13709647/

    Google Scholar 

  • Schwartz B, Hadar Y (2014) Possible mechanisms of action of mushroom-derived glucans on inflammatory bowel disease and associated cancer. Ann Transl Med 2(2):19

    PubMed  PubMed Central  Google Scholar 

  • Shibnev V, Garaev T, Finogenova M, Kalnina L, Nosik D (2015) Antiviral activity of aqueous extracts of the birch fungus Inonotus obliquus on the human immunodeficiency virus. Vopr Virusol 60(2):35–38

    CAS  PubMed  Google Scholar 

  • Shiitake JK (1995) The healing mushroom US: inner traditions/bear. ISBN 9780892814992

    Google Scholar 

  • Spelman K, Sutherland E, Bagade A (2017) Neurological activity of Lion’s Mane (Hericium erinaceus). J Restorative Med 6(1):19–26

    Article  Google Scholar 

  • Sun B, Wakame K, Sato E, Nishioka H, Aruoma OI, Fujii H (2009) The effect of active hexose correlated compound in modulating cytosine arabinoside-induced hair loss, and 6-mercaptopurine- and methotrexate-induced liver injury in rodents. Cancer Epidemiol 33(3):293–299

    Article  CAS  PubMed  Google Scholar 

  • Tan CS, Ng ST, Yap YHY, Lee SS, Lee ML, Fung SY et al (2012) Breathing new life to a Malaysia lost national treasure the tiger-milk mushroom (Lignosus rhinocerotis). In: Proceedings of the 18th congress of the International Society for Mushroom Science, pp 66–71

    Google Scholar 

  • Tan NH, Fung SY, Pailoor J, Tan CS, Ng ST (2016) Nutritional composition, antioxidant properties, and toxicology evaluation of the sclerotium of Tiger Milk mushroom Lignosus tigris cultivar E. Nut Res 36(2):174–183

    Article  CAS  Google Scholar 

  • Tang YJ, Zhong JJ (2002) Fed-batch fermentation of Ganoderma lucidum for hyperproduction of polysaccharide and ganoderic acid. Enzym Microb Technol 31(1–2):20–28

    Article  CAS  Google Scholar 

  • Tatjana K, Marina K (2013) Therapeutic properties of mushrooms in managing adverse effects in the metabolic syndrome. Curr Top Med Chem 13(21):2734–2744

    Article  CAS  Google Scholar 

  • Teplyakova TV, Kosogova TA (2016) Antiviral effect of Agaricomycetes mushrooms (review). Int J Med Mushrooms 18(5):375–386

    Article  PubMed  Google Scholar 

  • Torisu M, Hayashi Y, Ishimitsu T, Fujimura T, Iwasaki K, Katano M, Yamamoto H, Kimura Y, Takesue M, Kondo M et al (1990) Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer. Cancer Immunol Immunother 31(5):261–268

    Article  CAS  PubMed  Google Scholar 

  • Torkelson CJ, Sweet E, Martzen MR, Sasagawa M, Wenner CA, Gay J, Putiri A, Standish LJ (2012) Phase 1 clinical trial of Trametes versicolor in women with breast cancer. ISRN Oncology 2012:1–7. https://doi.org/10.5402/2012/251632

    Article  Google Scholar 

  • Tuli HS, Sandhu SS, Sharma A (2014) Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin. 3 Biotech 4(1):1–12

    Article  PubMed  Google Scholar 

  • Vitak T, Yurkiv B, Wasser S, Nevo E, Sybirna N (2017) Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus. World J of Diabetes 8(5):187–201

    Article  Google Scholar 

  • Wang HX, Ng TB (2001) Examination of lectins, polysaccharopeptide, polysaccharide, alkaloid, coumarin and trypsin inhibitors for inhibitory activity against human immunodeficiency virus reverse transcriptase and glycohydrolases. Planta Med 67(07):669–672

    Article  CAS  PubMed  Google Scholar 

  • Wasser SP (2002) Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol 60(3):258–274

    Article  CAS  PubMed  Google Scholar 

  • Wasser SP (2014) Medicinal mushroom science: Current perspectives, advances, evidences, and challenges. Biomed J 37(6):345–356

    Article  PubMed  Google Scholar 

  • Wasser SP, Weis AL (1999) Medicinal properties of substances occurring in higher basidiomycetes mushrooms: current perspectives. Int J Med Mushrooms 1(1):31–62

    Article  CAS  Google Scholar 

  • Wei H, Mohd Salleh S, Daud F, Zainal Z, Mazni Othman A, Mohd Saleh N (2014) Optimization of submerged culture conditions for the production of mycelial biomass and exopolysaccharides from Lignosus rhinocerus pp 73–80

    Google Scholar 

  • Weng Y, Xiang L, Matsuura A, Zhang Y, Huang Q, Qi J (2010) Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene. Bioorganic Med Chem 18(3):999–1002

    Article  CAS  Google Scholar 

  • Wong K-H, Lai CKM, Cheung PCK (2009) Stimulation of human innate immune cells by medicinal mushroom sclerotial polysaccharides. Evid-based Complement Altern Med 11(3):215–223

    CAS  Google Scholar 

  • Wu FC, Chen YL, Chang SM, Shih L (2013) Cultivation of medicinal caterpillar fungus, Cordyceps militaris (ascomycetes), and production of cordycepin using the spent medium from Levan fermentation. Int J Med Mush 15(4):393–405

    Article  Google Scholar 

  • Yang S, Jin L, Ren X, Lu J, Meng Q (2014) Optimization of fermentation process of Cordyceps militaris and antitumor activities of polysaccharides in vitro. J Food Drug Anal 22(4):468–476

    Article  CAS  PubMed  Google Scholar 

  • Yap HYY, Tan NH, Fung SY, Aziz AA, Tan CS, Ng ST (2013) Nutrient composition, antioxidant properties and antiproliferative activity of Lignosus rhinocerus Cooke sclerotium. J Sci Food Agric 93(12):2945–2952

    Article  CAS  PubMed  Google Scholar 

  • Yap HYY, Fung SY, Ng ST, Tan CS, Tan NH (2015) Shotgun proteomic analysis of tiger milk mushroom (Lignosus rhinocerotis) and the isolation of a cytotoxic fungal serine protease from its sclerotium. J Ethnopharmacol 174:437–451

    Article  CAS  PubMed  Google Scholar 

  • Yue K, Ye M, Lin X, Zhou Z (2013) The artificial cultivation of medicinal caterpillar fungus, Ophiocordyceps sinensis (Ascomycetes). Int J Med Mushrooms A review:425–434

    Article  PubMed  Google Scholar 

  • Zhang Z, Lv G, Pan H, Pandey A, He W, Fan L (2012) Antioxidant and hepatoprotective potential of endo-polysaccharides from Hericium erinaceus grown on tofu whey. Int J Biol Macromol 51(5):1140–1146

    Article  CAS  PubMed  Google Scholar 

  • Zhou S, Gao Y, Chan E (2005) Clinical trials for medicinal mushrooms: experience with Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Lingzhi mushroom). Int J Med Mushrooms 7(1&2):111–118

    Article  CAS  Google Scholar 

  • Zhu LN, Tang Q, Zhou S, Liu Y, Zhang Z, Gao X, Wang S, Wang Z (2014a) Isolation and purification of a polysaccharide from the caterpillar medicinal mushroom Cordyceps militaris (ascomycetes) fruit bodies and its immunomodulation of RAW 264.7 macrophages. Int J Med Mushrooms 16(3):247–257

    Article  PubMed  Google Scholar 

  • Zhu Y, Chen Y, Li Q, Zhao T, Zhang M, Feng W, Takase M, Wu X, Zhou Z, Yang L, Wu X (2014b) Preparation, characterization, and anti-Helicobacter pylori activity of Bi3+-Hericium erinaceus polysaccharide complex. Carbohydr Polym 110:231–237

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shin Yee Fung .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Cheong, P.C.H., Tan, C.S., Fung, S.Y. (2018). Medicinal Mushrooms: Cultivation and Pharmaceutical Impact. In: Singh, B., Lallawmsanga, Passari, A. (eds) Biology of Macrofungi. Fungal Biology. Springer, Cham. https://doi.org/10.1007/978-3-030-02622-6_14

Download citation

Publish with us

Policies and ethics