Pericytes in the Human Vocal Fold Mucosa

  • Kiminori SatoEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1109)


  1. 1.

    The human vocal fold is a vibrating tissue and vascular structures in organs which have the capacity to vibrate require a specific structure suitable for vibration.

  2. 2.

    The structure of the blood vessels is unique at the vocal fold edge as a vibrating tissue, where only small vessels, including arterioles, venules, and capillaries, are present. The capillaries are distributed in the superficial layer of the lamina propria (Reinke’s space).

  3. 3.

    The blood vessels enter the vocal fold edge from the anterior or posterior end of the membranous vocal fold and run essentially parallel to the vocal fold edge.

  4. 4.

    Many pericytes can be seen around the capillaries in the human vocal fold mucosa. The cell bodies of the pericytes attach to capillary endothelial cells, and the branching processes encircle the capillaries and attach to the capillary endothelial cells at the tips. The processes of pericytes are in close contact with endothelial cells, sharing a common basement membrane with them. The tips of the processes form intercellular tight junctions with endothelial cells.

  5. 5.

    The pericytes in the vocal fold mucosa appear to provide mechanical support and protection to the capillary walls, particularly during phonation. The pericytes also appear to regulate the diameter of the capillary during and after phonation. Pericytes are also thought to be critical cells in vascular biology and angiogenesis, especially in revascularization following vocal fold tissue injury.

  6. 6.

    At birth, pericytes have already encircled the capillaries in the newborn vocal fold mucosa. The pericytes appear ready to provide support and protection of the blood vessels just after birth.

  7. 7.

    Vascular structures and their permeability are related to the specific structures and specific diseases of the human vocal fold mucosa as a vibrating tissue.



Pericyte Capillary Human vocal fold mucosa Vibrating tissue 


  1. 1.
    Colton R, Woo P (2014) Measuring vocal fold function. In: Rubin J, Sataloff R, Korovin G (eds) Diagnosis and treatment of voice disorders, 4th edn. Plural Publishing, San Diego, pp 253–287Google Scholar
  2. 2.
    Fawcett DW (1994) Blood and lymph vascular systems. A textbook of histology. Chapman & Hall, New York, pp 368–409Google Scholar
  3. 3.
    Frenzel H, Kleinsasser O (1982) Ultrastructural study on the small blood vessels of human vocal cords. Arch Otorhinolaryngol 236:147–160CrossRefGoogle Scholar
  4. 4.
    Hirano M (1975) Phonosurgery. Basic and clinical investigation. Otologia (Fukuoka) 21(Suppl 1):239–442Google Scholar
  5. 5.
    Hirano M, Koike Y, Hirose K, Kasuya T (1974) Observation of mucous membrane of human vocal cords under electron microscopy. Jpn J Otol Tokyo 77:650–660Google Scholar
  6. 6.
    Hiroto I, Toyozumi Y, Tomita H, Miyagi T, Kuroki K, Koike Y, Matsushita H (1969) An experimental study on the hemodynamics of the vocal fold during vibration. Jpn J Otol Tokyo 72:884–888Google Scholar
  7. 7.
    Lebeux YJ, Willemot J (1978) Actin- and myosin-like filaments in rat brain pericytes. Anat Rec 190:811–826CrossRefGoogle Scholar
  8. 8.
    Mihashi S, Okada M, Kurita S, Nagata M, Oda M, Hirano M, Nakashima T (1981) Vascular network of the vocal fold. In: Stevens KN, Hirano M (eds) Vocal fold physiology. University of Tokyo Press, Tokyo, pp 45–59Google Scholar
  9. 9.
    Murakami M, Sugita A, Shimada T, Nakamura K (1979) Surface view of pericytes on the retinal capillary in rabbits revealed by scanning electron microscopy. Arch Histol Jpn 42:297–303CrossRefGoogle Scholar
  10. 10.
    Postma GN, Courey MS, Ossoff RH (1998) Microvascular lesions of the true vocal fold. Ann Otol Rhinol Laryngol 107:472–476CrossRefGoogle Scholar
  11. 11.
    Rhodin JA (1968) Ultrastructure of mammalian venous capillaries, venules, and small collection veins. J Ultrastruct Res 25:452–500CrossRefGoogle Scholar
  12. 12.
    Ribatti D, Nico B, Crivellato E (2011) The role of pericytes in angiogenesis. Int J Dev Biol 55:261–268CrossRefGoogle Scholar
  13. 13.
    Sato K (2018) Functional histoanatomy of the human larynx. Springer, SingaporeGoogle Scholar
  14. 14.
    Sato K, Hirano M (1997) Fine three-dimensional structure of pericytes in the vocal fold mucosa. Ann Otol Rhinol Laryngol 106:490–494CrossRefGoogle Scholar
  15. 15.
    Sato K, Hirano M, Nakashima T (1999) Electron microscopic and immunohistochemical investings of Reinke’s edema. Ann Otol Rhinol Laryngol 108:1068–1072CrossRefGoogle Scholar
  16. 16.
    Sheveiki D, Itin A, Soffer D, Keshet E (1992) Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843–845CrossRefGoogle Scholar
  17. 17.
    Shimada T, Nakamura M, Kitahara Y, Kawahara H (1982) Microvasculature of the rat mammary gland using the chemical digestion method. J Electron Microsc 31:185–190Google Scholar
  18. 18.
    Shimada T, Kitamura H, Nakamura M (1992) Three-dimensional architecture of pericytes with special reference to their topographical relationship to microvascular beds. Arch Histol Cytol 55:77–85CrossRefGoogle Scholar
  19. 19.
    Weibel ER (1974) On pericytes, particularly their existence on lung capillaries. Microvasc Res 8:218–235CrossRefGoogle Scholar
  20. 20.
    Zimmermann KW (1923) Der feinere Bau der Blutcapillaren. Z Anat Entwicklungsgesch 68:29–109CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of Otolaryngology-Head and Neck SurgeryKurume University School of MedicineKurumeJapan

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