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Remodelling Potential of the Mitral Heart Valve Leaflet

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Book cover Advances in Heart Valve Biomechanics

Abstract

Little is known about how normal valvular tissues grow and remodel in response to altered loading. In the present work, we used the pregnancy state to represent a non-pathological cardiac volume overload that distends the mitral valve (MV), utilizing both extant and new experimental data and a modified form of our MV structural constitutive model. We determined that there was an initial period of permanent set-like deformation where no remodelling occurs, followed by a remodelling phase which resulted in near-complete restoration of homeostatic tissue-level behaviour. In addition, we observed that changes in the underlying MV interstitial cell (MVIC) geometry closely paralleled the tissue-level remodelling events, undergoing an initial passive perturbation followed by a gradual recovery to the pre-pregnant state. Collectively, these results suggest that valvular remodelling is actively mediated by average MVIC deformations (i.e. not cycle to cycle, but over a period of weeks).

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Acknowledgments

This material is based upon work supported by the National Institutes of Health grant no. R01-HL119297 to MSS, the National Science Foundation grant no. DGE-1610403 to BVR, an American Heart Association Scientist Development Grant Award (16SDG27760143) to CHL, and a Natural Sciences and Engineering Research Council of Canada Discovery Grant to SMW.

Author information

Authors and Affiliations

  1. James T. Willerson Center for Cardiovascular Modeling and Simulation, Institute for Computational Engineering and Sciences, Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA

    Bruno V. Rego & Chung-Hao Lee

  2. School of Biomedical Engineering, Dalhousie University, Halifax, NS, Canada

    Sarah M. Wells

  3. School of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK, USA

    Chung-Hao Lee

  4. The Oden Institute and the Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA

    Michael S. Sacks

Authors
  1. Bruno V. Rego
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  2. Sarah M. Wells
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  3. Chung-Hao Lee
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  4. Michael S. Sacks
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Corresponding author

Correspondence to Michael S. Sacks .

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Editors and Affiliations

  1. The Oden Institute and the Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA

    Michael S. Sacks

  2. The Department of Bioengineering, The University of Texas at Arlington, Arlington, TX, USA

    Jun Liao

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Rego, B.V., Wells, S.M., Lee, CH., Sacks, M.S. (2018). Remodelling Potential of the Mitral Heart Valve Leaflet. In: Sacks, M., Liao, J. (eds) Advances in Heart Valve Biomechanics. Springer, Cham. https://doi.org/10.1007/978-3-030-01993-8_8

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