Abstract
The level of physical stress rules the adaptative response of peripheral nerves, which is crucial to assess their physiological and pathological states. To this aim, in this work, a hybrid computational approach was presented to model the stress response of in vitro peripheral nerves undergoing longitudinal stretch. In addition, the rate of change of stiffness with strain was investigated and quantified through the secant modulus in order to achieve a quantitative framework, providing crucial information for both physical rehabilitation and biomaterial science.
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References
Alexander, M.J., Barkmeier-Kraemer, J.M., Vande Geest, J.P.: Biomechanical properties of recurrent laryngeal nerve in the piglet. Ann. Biomed. Eng. 38(8), 2553–2562 (2010)
Anderson, J.M., Rodriguez, A., Chang, D.T.: Foreign body reaction to biomaterials. Seminars Immunol. 20(2), 86–100 (2008). Innate and Adaptive Immune Responses in Tissue Engineering
Daly, W., Yao, L., Zeugolis, D., Windebank, A., Pandit, A.: A biomaterials approach to peripheral nerve regeneration: bridging the peripheral nerve gap and enhancing functional recovery. J. R. Soc. Interface 9(67), 202–221 (2011)
Dilley, A., Lynn, B., Greening, J., DeLeon, N.: Quantitative in vivo studies of median nerve sliding in response to wrist, elbow, shoulder and neck movements. Clin. Biomech. 18(10), 899–907 (2003)
Dilley, A., Summerhayes, C., Lynn, B.: An in vivo investigation of ulnar nerve sliding during upper limb movements. Clinical Biomech. 22(7), 774–779 (2007)
Giannessi, E., Stornelli, M.R., Sergi, P.N.: A unified approach to model peripheral nerves across different animal species. PeerJ 5, e4005 (2017)
Giannessi, E., Stornelli, M.R., Sergi, P.N.: Fast in silico assessment of physical stress for peripheral nerves. Med. Biol. Eng. Comput. 56, 1541–1551 (2018)
Lacour, S.P., Courtine, G., Guck, J.: Materials and technologies for soft implantable neuroprostheses. Nature Rev. Mater. 1, 16063 (2016)
Lundborg, G.: Limb ischemia and nerve injury. Arch. Surg. 104(5), 631–632 (1972)
Lundborg, G.: Peripheral nerve injuries: pathophysiology and strategies for treatment. J. Hand. Ther. 6(3), 179–188 (1993)
Ma, Z., Hu, S., Tan, J.S., Myer, C., Njus, N.M., Xia, Z.: In vitro and in vivo mechanical properties of human ulnar and median nerves. J. Biomed. Mater. Res. A 101(9), 2718–2725 (2013)
Main, E.K., Goetz, J.E., Rudert, M.J., Goreham-Voss, C.M., Brown, T.D.: Apparent transverse compressive material properties of the digital flexor tendons and the median nerve in the carpal tunnel. J. Biomech. 44(5), 863–868 (2011)
Millesi, H., Zoch, G., Reihsner, R.: Mechanical properties of peripheral nerves. Clin. Orthop. Relat. Res. 314, 76–83 (1995)
Sunderland, S.: The anatomic foundation of peripheral nerve repair techniques. Orthop. Clin. North Am. 12(2), 245–266 (1981)
Topp, K.S., Boyd, B.S.: Structure and biomechanics of peripheral nerves: nerve responses to physical stresses and implications for physical therapist practice. Phys. Ther. 86(1), 92–109 (2006)
Williams, M.J., Utzinger, U., Barkmeier-Kraemer, J.M., Vande Geest, J.P.: Differences in the microstructure and biomechanical properties of the recurrent laryngeal nerve as a function of age and location. J. Biomech. Eng. 136(8), 0810081–0810089 (2014)
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Giannessi, E., Stornelli, M.R., Sergi, P.N. (2019). A Hybrid Framework to Investigate Physical Stress Evolution in Peripheral Nerves. In: Masia, L., Micera, S., Akay, M., Pons, J. (eds) Converging Clinical and Engineering Research on Neurorehabilitation III. ICNR 2018. Biosystems & Biorobotics, vol 21. Springer, Cham. https://doi.org/10.1007/978-3-030-01845-0_28
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DOI: https://doi.org/10.1007/978-3-030-01845-0_28
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