Abstract
In this study we considered the role of the inhibitory interneurons known as Renshaw cells (RC) in the activity of a simulated locomotor neural network. We used a n integrate-and fire-model to reproduce RCs experimental three-phases responses, consisting of a fast activation, a relaxation time and a slow activation. Simulations of RCs within a model of muscle spindle reflex neural network highlighted multiple roles of Renshaw cells in locomotion. We found that RCs synchronize the pool of motor neurons (MNs) they act on, and regulate the relative duration of the antagonist muscle bursts during the gait cycle. This refined model can be used to simulate the interaction between electrodes and spinal circuits to improve the efficacy of spinal cord stimulation protocols.
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References
Jackson, A.: Neural interfaces for the brain and spinal cord–restoring motor function. Nat. Rev. Neurol. 8(12), 690–699 (2012)
Angeli, C.E.: Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in humans. Brain 137, 1394–1409 (2014)
Hofstoetter, U.D.: Periodic modulation of repetitively elicited monosynaptic reflexes of the human lumbosacral spinal cord. J. Neurophysiol. (2015). https://doi.org/10.1152/jn.00136.2015
Moraud, E.M., Capogrosso, M., Formento, E., Wenger, N., DiGiovanna, J., Courtine, G., Micera, S.: Mechanisms underlying the neuromodulation of spinal circuits for correcting gait and balance deficits after spinal cord injury. Neuron 89, 814–828 (2016)
Renshaw, B.: Central effects of centripetal impulses in axons of spinal ventral roots. J. Neurophysiol. 9, 191–204 (1946)
Hultborn, H., Denton, M.E., Wienecke, J., Nielsen, J.B.: Variable amplification of synaptic input to cat spinal motoneurones by dendritic persistent inward current. J. Physiol. 552(Pt 3), 945–952 (2003)
Maltenfort, M.G., Heecan, C.J., Rymer, W.Z.: Decorrelation actions of Renshaw interneuron on the firing of spinal motoneurons within a motor nucleus: a stimulation study. J. Neurophysiol. 80, 309–323 (1998)
Windhorst, U.: Activation of Renshaw cells. Prog. Neurobiol. 35, 135–179 (1990)
Nishimaru, H., Koganezawa, T., Kakizaki, M., Ebihara, T., Yanagawa, Y.: Inhibitory synaptic modulation of Renshaw cell activity in the lumbar spinal cord of neonatal mice. J. Neurophysiol. 103, 3437–3447 (2010)
Carnevale, N., Hines, M.: The Neuron Book. Cambridge University Press, Cambridge (2009)
Bashor, D.P.: A large-scale model of some spinal reflex circuits. Biol. Cybern. 78(2), 147–157 (1998)
Stienen, A.H.A., Schouten, A.C., Schuurmans, J., van der Helm, F.C.T.: Analysis of reflex modulation with a biologically realistic neural network. J. Comput. Neurosci. 23, 333–348 (2007)
Kreuz, T., Haas, J., Morelli, A., Abarbanel, H.D.I., Politi, A.: Measuring spike train synchrony. J. Neurosci. Methods 165, 151–161 (2007)
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Corsi, P., Formento, E., Capogrosso, M., Micera, S. (2019). Role of Renshaw Cells in the Mammalian Locomotor Circuit: A Computational Study. In: Masia, L., Micera, S., Akay, M., Pons, J. (eds) Converging Clinical and Engineering Research on Neurorehabilitation III. ICNR 2018. Biosystems & Biorobotics, vol 21. Springer, Cham. https://doi.org/10.1007/978-3-030-01845-0_21
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DOI: https://doi.org/10.1007/978-3-030-01845-0_21
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