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Nanotheranostics for Cancer Applications pp 231–251Cite as

Topical and Transdermal Nanomedicines for Cancer Therapy

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Part of the book series: Bioanalysis ((BIOANALYSIS,volume 5))

Abstract

Topical and transdermal nanomedicine systems have attracted considerable attention in anticancer therapy. The administration route toward the skin can transport active drugs through the skin barrier and control their entrance into the blood circulation system. Agents delivered through this platform are capable of escaping the first pass of metabolism, which causes physiological degradation of the agent and systemic clearance. Apart from methodology to facilitate the delivery of drug transdermally, the formulation of nanomedicines to preserve the therapeutic’s property is also critical for overall clinical outcomes. This strategy improves the efficiency of encapsulated drugs by potentiating the targeting capability and tailoring the release kinetics toward specific tumors. This chapter summarizes the principles and the recent innovations in the field of transdermal nanomedicine together with opportunities and challenges in clinical translation. For the continued development of novel transdermal devices incorporating nanotechnology, a deeper understanding is required in rational nanoparticle design and their pharmacokinetics.

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Authors and Affiliations

  1. Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, USA

    Yanqi Ye, Jinqiang Wang, Wujin Sun, Hunter N. Bomba & Zhen Gu

  2. Division of Pharmacoengineering and Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Yanqi Ye, Jinqiang Wang, Wujin Sun & Zhen Gu

  3. Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Zhen Gu

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  1. Yanqi Ye
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  1. Department of Chemical Engineering, University of Massachusetts Lowell, Lowell, MA, USA

    Prakash Rai

  2. National Cancer Institute, NIH Nanodelivery Systems and Devices Branch Cancer Imaging Program, Division of Cancer Treatment and Diagnosis, Rockville, MD, USA

    Stephanie A. Morris

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Ye, Y., Wang, J., Sun, W., Bomba, H.N., Gu, Z. (2019). Topical and Transdermal Nanomedicines for Cancer Therapy. In: Rai, P., Morris, S.A. (eds) Nanotheranostics for Cancer Applications. Bioanalysis, vol 5. Springer, Cham. https://doi.org/10.1007/978-3-030-01775-0_10

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