18F-FDG-PET/CT (FDG-PET) in Neurodegenerative Disease

  • Selene Capitanio
  • Matteo Bauckneht
  • Dario Arnaldi
  • Federico Massa
  • Riccardo Meli
  • Valentina Ceriani
  • Flavio Nobili
  • Silvia MorbelliEmail author
Part of the Clinicians’ Guides to Radionuclide Hybrid Imaging book series (CGRHI)


Neurodegenerative diseases are a heterogeneous group of conditions due to different etiologies and different neuropathological and neurochemical alterations leading to different clinical pictures and courses.

With its peculiar ability to noninvasively reflect cerebral synaptic density and activity, FDG-PET plays a major role in evaluating the extent and localization of neuronal dysfunction, thus characterizing the endophenotype of a neuronal injury.

The identification of typical patterns of hypometabolism since the earliest stages of neurodegenerative diseases can support clinicians in differential diagnosis, especially in atypical and challenging cases.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Selene Capitanio
    • 1
  • Matteo Bauckneht
    • 1
  • Dario Arnaldi
    • 2
  • Federico Massa
    • 2
  • Riccardo Meli
    • 2
  • Valentina Ceriani
    • 1
  • Flavio Nobili
    • 2
  • Silvia Morbelli
    • 1
    Email author
  1. 1.Department of Health Sciences (DiSSAL)University of Genoa and Nuclear Medicine Unit, Polyclinic San Martino HospitalGenoaItaly
  2. 2.Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Mother-Child Health (DINOGMI), Clinical Neurology, Polyclinic San Martino HospitalUniversity of GenoaGenoaItaly

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