Interstitial Brachytherapy - Definitive and Adjuvant

Part of the Practical Guides in Radiation Oncology book series (PGRO)


Gynecologic interstitial brachytherapy (ISBT) is the placement of catheters into and surrounding a tumor, with either a high-dose-rate (HDR) and low-dose-rate (LDR) technique. Using an HDR technique, the catheters are afterloaded with radioactive sources, the most common isotope being 192Ir. Brachytherapy (BT) is a key component in the treatment of gynecological cancers, as it allows for dose escalation to the tumor while minimizing the dose to surrounding critical organs at risk, such as the sigmoid, bladder, and rectum. Patterns of care studies established the essential role of BT in the management of cervical cancer and linked its use to improvements in pelvic control and disease-free survival. Furthermore, the use of image-guided BT shows improvement in pelvic control and disease-free survival based on a large review from the American Brachytherapy Cervical Cancer Task Force.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Radiation OncologyUniversity of California Davis HealthSacramentoUSA
  2. 2.Department of Radiation OncologyUniversity of San Diego HealthSan DiegoUSA
  3. 3.Department of Radiation OncologyCedars-Sinai Medical CenterLos AngelesUSA
  4. 4.Department of Radiation OncologyUniversity of Pittsburgh Medical CenterPittsburghUSA
  5. 5.Department of Medical PhysicsMemorial Sloan Kettering Cancer CenterNew YorkUSA

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