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Interstitial Brachytherapy - Definitive and Adjuvant

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Radiation Therapy Techniques for Gynecological Cancers

Part of the book series: Practical Guides in Radiation Oncology ((PGRO))

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Abstract

Gynecologic interstitial brachytherapy (ISBT) is the placement of catheters into and surrounding a tumor, with either a high-dose-rate (HDR) and low-dose-rate (LDR) technique. Using an HDR technique, the catheters are afterloaded with radioactive sources, the most common isotope being 192Ir. Brachytherapy (BT) is a key component in the treatment of gynecological cancers, as it allows for dose escalation to the tumor while minimizing the dose to surrounding critical organs at risk, such as the sigmoid, bladder, and rectum. Patterns of care studies established the essential role of BT in the management of cervical cancer and linked its use to improvements in pelvic control and disease-free survival. Furthermore, the use of image-guided BT shows improvement in pelvic control and disease-free survival based on a large review from the American Brachytherapy Cervical Cancer Task Force.

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References

  1. Hanks GE, Herring DF, Kramer S. Patterns of care outcome studies. Results of the national practice in cancer of the cervix. Cancer. 1983;51(5):959–67.

    Article  CAS  PubMed  Google Scholar 

  2. Mayadev J, et al. American Brachytherapy Task Group Report: a pooled analysis of clinical outcomes for high-dose-rate brachytherapy for cervical cancer. Brachytherapy. 2017;16(1):22–43.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Potter R, et al. Clinical impact of MRI assisted dose volume adaptation and dose escalation in brachytherapy of locally advanced cervix cancer. Radiother Oncol. 2007;83(2):148–55.

    Article  PubMed  Google Scholar 

  4. Potter R, et al. Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer. Radiother Oncol. 2011;100(1):116–23.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Lee LJ, Damato AL, Viswanathan AN. Clinical outcomes of high-dose-rate interstitial gynecologic brachytherapy using real-time CT guidance. Brachytherapy. 2013;12(4):303–10.

    Article  PubMed  Google Scholar 

  6. Demanes DJ, et al. High dose rate transperineal interstitial brachytherapy for cervical cancer: high pelvic control and low complication rates. Int J Radiat Oncol Biol Phys. 1999;45(1):105–12.

    Article  CAS  PubMed  Google Scholar 

  7. Hsu IC, et al. A comparison between tandem and ovoids and interstitial gynecologic template brachytherapy dosimetry using a hypothetical computer model. Int J Radiat Oncol Biol Phys. 2002;52(2):538–43.

    Article  PubMed  Google Scholar 

  8. Davidson MT, et al. Image-guided cervix high-dose-rate brachytherapy treatment planning: does custom computed tomography planning for each insertion provide better conformal avoidance of organs at risk? Brachytherapy. 2008;7:37–42.

    Article  PubMed  Google Scholar 

  9. Gao M, et al. 3D CT-based volumetric dose assessment of 2D plans using GEC-ESTRO guidelines for cervical cancer brachytherapy. Brachytherapy. 2010;9(1):55–60.

    Article  PubMed  Google Scholar 

  10. Haie-Meder C, et al. Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (I): concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV. Radiother Oncol. 2005;74(3):235–45.

    Article  PubMed  Google Scholar 

  11. Potter R, Haie-Meder C, Limbergenc E. Recommendations from gynaecological (GYN) GEC ESTRO working group (II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy—3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology. Radiother Oncol. 2006;78:67–77.

    Article  PubMed  Google Scholar 

  12. Pötter R, et al. Present status and future of high-precision image guided adaptive brachytherapy for cervix carcinoma. Acta Oncol. 2008;47(7):1325–36.

    Article  PubMed  Google Scholar 

  13. van Dyk S, Byram D, Bernshaw D. Use of 3D imaging and awareness of GEC-ESTRO recommendations for cervix cancer brachytherapy throughout Australia and New Zealand. J Med Imaging Radiat Oncol. 2010;54(4):383–7.

    Article  PubMed  Google Scholar 

  14. Pavamani S, et al. Image-guided brachytherapy for cervical cancer: a Canadian Brachytherapy Group survey. Brachytherapy. 2011;10(5):345–51.

    Article  PubMed  Google Scholar 

  15. Grover S, et al. Image guided cervical brachytherapy: 2014 survey of the American Brachytherapy Society. Int J Radiat Oncol Biol Phys. 2016;94(3):598–604.

    Article  PubMed  Google Scholar 

  16. Sturdza A, et al. Image guided brachytherapy in locally advanced cervical cancer: improved pelvic control and survival in RetroEMBRACE, a multicenter cohort study. Radiother Oncol. 2016;120(3):428–33.

    Article  PubMed  Google Scholar 

  17. Kirisits C, et al. The Vienna applicator for combined intracavitary and interstitial brachytherapy of cervical cancer: design, application, treatment planning, and dosimetric results. Int J Radiat Oncol Biol Phys. 2006;65(2):624–30.

    Article  PubMed  Google Scholar 

  18. Fokdal L, et al. Image guided adaptive brachytherapy with combined intracavitary and interstitial technique improves the therapeutic ratio in locally advanced cervical cancer: analysis from the retroEMBRACE study. Radiother Oncol. 2016;120(3):434–40.

    Article  PubMed  Google Scholar 

  19. Martinez A, Cox RS, Edmundson GK. A multiple-site perineal applicator (MUPIT) for treatment of prostatic, anorectal, and gynecologic malignancies. Int J Radiat Oncol Biol Phys. 1984;10(2):297–305.

    Article  CAS  PubMed  Google Scholar 

  20. Mendez LC, et al. Three-dimensional-guided perineal-based interstitial brachytherapy in cervical cancer: a systematic review of technique, local control and toxicities. Radiother Oncol. 2017;123(2):312–8.

    Article  PubMed  Google Scholar 

  21. Fallon J, et al. Long term results from a prospective database on high dose rate (HDR) interstitial brachytherapy for primary cervical carcinoma. Gynecol Oncol. 2016. https://doi.org/10.1016/j.ygyno.2016.10.020.

    Article  Google Scholar 

  22. Kamran SC, et al. Comparison of outcomes for MR-guided versus CT-guided high-dose-rate interstitial brachytherapy in women with locally advanced carcinoma of the cervix. Gynecol Oncol. 2017;145(2):284–90.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Manuel MM, et al. Outcomes with image-based interstitial brachytherapy for vaginal cancer. Radiother Oncol. 2016;120(3):486–92.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Dimopoulos JC, et al. Treatment of locally advanced vaginal cancer with radiochemotherapy and magnetic resonance image-guided adaptive brachytherapy: dose-volume parameters and first clinical results. Int J Radiat Oncol Biol Phys. 2012;82(5):1880–8.

    Article  PubMed  Google Scholar 

  25. Beriwal S, et al. High-dose rate brachytherapy (HDRB) for primary or recurrent cancer in the vagina. Radiat Oncol. 2008;3:7.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Mahantshetty U, et al. Clinical outcome of high-dose-rate interstitial brachytherapy in vulvar cancer: a single institutional experience. Brachytherapy. 2017;16(1):153–60.

    Article  PubMed  Google Scholar 

  27. Castelnau-Marchand P, et al. Brachytherapy as part of the conservative treatment for primary and recurrent vulvar carcinoma. Brachytherapy. 2017;16(3):518–25.

    Article  CAS  PubMed  Google Scholar 

  28. Kellas-Sleczka S, et al. Interstitial high-dose-rate brachytherapy in locally advanced and recurrent vulvar cancer. J Contemp Brachytherapy. 2016;8(1):32–40.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Kamran SC, Manuel MM, Catalano P, et al. MR-versus CT-based high-dose-rate interstitial brachytherapy for vaginal recurrence of endometrial cancer. Brachytherapy. 2017;16(6):1159–68. https://doi.org/10.1016/j.brachy.2017.07.007.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Fokdal L, et al. Toward four-dimensional image-guided adaptive brachytherapy in locally recurrent endometrial cancer. Brachytherapy. 2014;13(6):554–61.

    Article  PubMed  Google Scholar 

  31. Vargo JA, et al. Definitive salvage for vaginal recurrence of endometrial cancer: the impact of modern intensity-modulated-radiotherapy with image-based HDR brachytherapy and the interplay of the PORTEC 1 risk stratification. Radiother Oncol. 2014;113(1):126–31.

    Article  PubMed  Google Scholar 

  32. Kamrava M, et al. American Brachytherapy Society recurrent carcinoma of the endometrium task force patterns of care and review of the literature. Brachytherapy. 2017;16:1129.

    Article  PubMed  Google Scholar 

  33. Martinez-Monge R, et al. Phase II trial of image-based high-dose-rate interstitial brachytherapy for previously irradiated gynecologic cancer. Brachytherapy. 2014;13(3):219–24.

    Article  PubMed  Google Scholar 

  34. Mahantshetty U, et al. Reirradiation using high-dose-rate brachytherapy in recurrent carcinoma of uterine cervix. Brachytherapy. 2014;13(6):548–53.

    Article  PubMed  Google Scholar 

  35. Zolciak-Siwinska A, et al. Computed tomography-planned high-dose-rate brachytherapy for treating uterine cervical cancer. Int J Radiat Oncol Biol Phys. 2016;96(1):87–92.

    Article  PubMed  Google Scholar 

  36. Huang K, et al. High-dose-rate interstitial brachytherapy for the treatment of high-volume locally recurrent endometrial carcinoma. Brachytherapy. 2016;15(5):543–8.

    Article  PubMed  Google Scholar 

  37. Feddock J, et al. Outpatient template-guided permanent interstitial brachytherapy using 131Cs in gynecologic malignancies: initial report. Brachytherapy. 2017;16(2):393–401.

    Article  PubMed  Google Scholar 

  38. Girinsky T, et al. Overall treatment time in advanced cervical carcinomas: a critical parameter in treatment outcome. Int J Radiat Oncol Biol Phys. 1993;27(5):1051–6.

    Article  CAS  PubMed  Google Scholar 

  39. Perez CA, et al. Carcinoma of the uterine cervix. I. Impact of prolongation of overall treatment time and timing of brachytherapy on outcome of radiation therapy. Int J Radiat Oncol Biol Phys. 1995;32(5):1275–88.

    Article  CAS  PubMed  Google Scholar 

  40. Shaverdian N, et al. Effects of treatment duration during concomitant chemoradiation therapy for cervical cancer. Int J Radiat Oncol Biol Phys. 2013;86(3):562–8.

    Article  PubMed  Google Scholar 

  41. Syed AMN, Puthawala A, Neblett D. Transperineal interstitial-intracavitary “Syed-Neblett” applicator in the treatment of carcinoma of the uterine cervix. Endocurie Hypertherm Oncol. 1986;2:1–13.

    Google Scholar 

  42. van der Vyver M, Halpern S, Joseph G. Patient-controlled epidural analgesia versus continuous infusion for labour analgesia: a meta-analysis. Br J Anaesth. 2002;89(3):459–65.

    Article  PubMed  Google Scholar 

  43. Dyer BA, et al. Sustainable gynecological brachytherapy in an increasingly cost-aware healthcare system: conversion of labor-intense interstitial brachytherapy to hybrid intracavitary brachytherapy for locally advanced cervical cancer. Brachytherapy. 2017;16(3):S58–9.

    Article  Google Scholar 

  44. Corn BW, et al. Improved treatment planning for the Syed-Neblett template using endorectal-coil magnetic resonance and intraoperative (laparotomy/laparoscopy) guidance: a new integrated technique for hysterectomized women with vaginal tumors. Gynecol Oncol. 1995;56(2):255–61.

    Article  CAS  PubMed  Google Scholar 

  45. Popowski Y, et al. Open magnetic resonance imaging using titanium-zirconium needles: improved accuracy for interstitial brachytherapy implants? Int J Radiat Oncol Biol Phys. 2000;47(3):759–65.

    Article  CAS  PubMed  Google Scholar 

  46. Viswanathan AN, et al. Magnetic resonance-guided interstitial therapy for vaginal recurrence of endometrial cancer. Int J Radiat Oncol Biol Phys. 2006;66(1):91–9.

    Article  PubMed  Google Scholar 

  47. Viswanathan AN, et al. A prospective trial of real-time magnetic resonance-guided catheter placement in interstitial gynecologic brachytherapy. Brachytherapy. 2013;12(3):240–7.

    Article  PubMed  Google Scholar 

  48. Feldmeier J, Mok E, Ditzel D, et al. A technique for transperineal template implants with compute tomographic guidance and dosimtery and local anesthesia. Endocurie Hypertherm Oncol. 1992;8:105–11.

    Google Scholar 

  49. Erickson B, Albano K, Gillin M. CT-guided interstitial implantation of gynecologic malignancies. Int J Radiat Oncol Biol Phys. 1996;36(3):699–709.

    Article  CAS  PubMed  Google Scholar 

  50. Eisbruch A, et al. Customized gynecologic interstitial implants: CT-based planning, dose evaluation, and optimization aided by laparotomy. Int J Radiat Oncol Biol Phys. 1998;40(5):1087–93.

    Article  CAS  PubMed  Google Scholar 

  51. Nag S, et al. Interstitial brachytherapy for salvage treatment of vaginal recurrences in previously unirradiated endometrial cancer patients. Int J Radiat Oncol Biol Phys. 2002;54(4):1153–9.

    Article  PubMed  Google Scholar 

  52. Nag S, et al. The use of fluoroscopy to guide needle placement in interstitial gynecological brachytherapy. Int J Radiat Oncol Biol Phys. 1998;40(2):415–20.

    Article  CAS  PubMed  Google Scholar 

  53. Stock RG, et al. A new technique for performing Syed-Neblett template interstitial implants for gynecologic malignancies using transrectal-ultrasound guidance. Int J Radiat Oncol Biol Phys. 1997;37(4):819–25.

    Article  CAS  PubMed  Google Scholar 

  54. Sharma DN, et al. Use of transrectal ultrasound for high dose rate interstitial brachytherapy for patients of carcinoma of uterine cervix. J Gynecol Oncol. 2010;21(1):12–7.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Rodgers JR, et al. Toward a 3D transrectal ultrasound system for verification of needle placement during high-dose-rate interstitial gynecologic brachytherapy. Med Phys. 2017;44(5):1899–911.

    Article  CAS  PubMed  Google Scholar 

  56. Kamrava M. Potential role of ultrasound imaging in interstitial image based cervical cancer brachytherapy. J Contemp Brachytherapy. 2014;6(2):223–30.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Alcazar JL, Jurado M. Three-dimensional ultrasound for assessing women with gynecological cancer: a systematic review. Gynecol Oncol. 2011;120(3):340–6.

    Article  PubMed  Google Scholar 

  58. Beriwal S, et al. High-dose-rate interstitial brachytherapy for gynecologic malignancies. Brachytherapy. 2006;5(4):218–22.

    Article  PubMed  Google Scholar 

  59. Beriwal S, et al. Three-dimensional image-based high-dose-rate interstitial brachytherapy for vaginal cancer. Brachytherapy. 2012;11(3):176–80.

    Article  PubMed  Google Scholar 

  60. Childers JM, Brainard P, Rogoff EE, Surwit EA. Laparoscopically assisted transperineal interstitial irradiation and surgical staging for advanced cervical carcinoma. Endocurie Hypertherm Oncol. 1994;10:83–6.

    Google Scholar 

  61. Recio FO, et al. Laparoscopic-assisted application of interstitial brachytherapy for locally advanced cervical carcinoma: results of a pilot study. Int J Radiat Oncol Biol Phys. 1998;40(2):411–4.

    Article  CAS  PubMed  Google Scholar 

  62. Choi JC, et al. Potential decreased morbidity of interstitial brachytherapy for gynecologic malignancies using laparoscopy: a pilot study. Gynecol Oncol. 1999;73(2):210–5.

    Article  CAS  PubMed  Google Scholar 

  63. Lim J, et al. The impact of maximum rectal distention and tandem angle on rectal dose delivered in 3D planned gynecologic high dose-rate brachytherapy. Int J Gynecol Cancer. 2013;23(6):1078–83.

    Article  PubMed  PubMed Central  Google Scholar 

  64. Dimopoulos JC, et al. Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (IV): basic principles and parameters for MR imaging within the frame of image based adaptive cervix cancer brachytherapy. Radiother Oncol. 2012;103(1):113–22.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Beriwal S, et al. American Brachytherapy Society consensus guidelines for interstitial brachytherapy for vaginal cancer. Brachytherapy. 2012;11(1):68–75.

    Article  PubMed  Google Scholar 

  66. Shah AP, et al. Toxicity associated with bowel or bladder puncture during gynecologic interstitial brachytherapy. Int J Radiat Oncol Biol Phys. 2010;77(1):171–9.

    Article  PubMed  Google Scholar 

  67. Tanderup K, et al. Magnetic resonance image guided brachytherapy. Semin Radiat Oncol. 2014;24(3):181–91.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Haack S, et al. Applicator reconstruction in MRI 3D image-based dose planning of brachytherapy for cervical cancer. Radiother Oncol. 2009;91(2):187–93.

    Article  PubMed  Google Scholar 

  69. Hu Y, et al. Improve definition of titanium tandems in MR-guided high dose rate brachytherapy for cervical cancer using proton density weighted MRI. Radiat Oncol. 2013;8:16.

    Article  PubMed  PubMed Central  Google Scholar 

  70. Schindel J, et al. Magnetic resonance imaging (MRI) markers for MRI-guided high-dose-rate brachytherapy: novel marker-flange for cervical cancer and marker catheters for prostate cancer. Int J Radiat Oncol Biol Phys. 2013;86(2):387–93.

    Article  PubMed  Google Scholar 

  71. Potter R, et al. Recommendations from gynaecological (GYN) GEC ESTRO working group (II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology. Radiother Oncol. 2006;78(1):67–77.

    Article  PubMed  Google Scholar 

  72. Report 89. J ICRU. 2013;13(1-2):NP. https://doi.org/10.1093/jicru/ndw042.

  73. Viswanathan AN, et al. Computed tomography versus magnetic resonance imaging-based contouring in cervical cancer brachytherapy: results of a prospective trial and preliminary guidelines for standardized contours. Int J Radiat Oncol Biol Phys. 2007;68(2):491–8.

    Article  PubMed  Google Scholar 

  74. Glaser S, Kim H, Beriwal S. Effect of imaging modality on urethral dosimetry in patients undergoing gynecological brachytherapy. Brachytherapy. 2016;15:S87.

    Article  Google Scholar 

  75. Georg P, et al. Dose effect relationship for late side effects of the rectum and urinary bladder in magnetic resonance image-guided adaptive cervix cancer brachytherapy. Int J Radiat Oncol Biol Phys. 2012;82(2):653–7.

    Article  PubMed  Google Scholar 

  76. Charra-Brunaud C, et al. Impact of 3D image-based PDR brachytherapy on outcome of patients treated for cervix carcinoma in France: results of the French STIC prospective study. Radiother Oncol. 2012;103(3):305–13.

    Article  PubMed  Google Scholar 

  77. Mayadev JS, Benedict S. In: Benedict S, Mayadev JS, Kamrava M, editors. Handbook of image-guided brachytherapy. Cham: Springer; 2017. p. 630.

    Chapter  Google Scholar 

  78. Denham JW, Hauer-Jensen M. The radiotherapeutic injury—a complex ‘wound’. Radiother Oncol. 2002;63(2):129–45.

    Article  PubMed  Google Scholar 

  79. Booth C, et al. Acute gastrointestinal syndrome in high-dose irradiated mice. Health Phys. 2012;103(4):383–99.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Nout RA, et al. Five-year quality of life of endometrial cancer patients treated in the randomised Post Operative Radiation Therapy in Endometrial Cancer (PORTEC-2) trial and comparison with norm data. Eur J Cancer. 2012;48(11):1638–48.

    Article  PubMed  Google Scholar 

  81. Feyer P, Jahn F, Jordan K. Radiation induced nausea and vomiting. Eur J Pharmacol. 2014;722:165–71.

    Article  CAS  PubMed  Google Scholar 

  82. Nussbaum ML, Campana TJ, Weese JL. Radiation-induced intestinal injury. Clin Plast Surg. 1993;20(3):573–80.

    CAS  PubMed  Google Scholar 

  83. Chitapanarux I, et al. Randomized controlled trial of live lactobacillus acidophilus plus bifidobacterium bifidum in prophylaxis of diarrhea during radiotherapy in cervical cancer patients. Radiat Oncol. 2010;5:31.

    Article  PubMed  PubMed Central  Google Scholar 

  84. Urbancsek H, et al. Results of a double-blind, randomized study to evaluate the efficacy and safety of Antibiophilus in patients with radiation-induced diarrhoea. Eur J Gastroenterol Hepatol. 2001;13(4):391–6.

    Article  CAS  PubMed  Google Scholar 

  85. Delia P, et al. Use of probiotics for prevention of radiation-induced diarrhea. World J Gastroenterol. 2007;13(6):912–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. Salminen E, et al. Preservation of intestinal integrity during radiotherapy using live Lactobacillus acidophilus cultures. Clin Radiol. 1988;39(4):435–7.

    Article  CAS  PubMed  Google Scholar 

  87. Kilic D, et al. Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of sulphasalazine in preventing acute gastrointestinal complications due to radiotherapy. Radiother Oncol. 2000;57(2):125–9.

    Article  CAS  PubMed  Google Scholar 

  88. Dennis K, et al. Radiotherapy-induced nausea and vomiting. Expert Rev Pharmacoecon Outcomes Res. 2011;11(6):685–92.

    Article  PubMed  Google Scholar 

  89. Vernia P, et al. Topical butyrate for acute radiation proctitis: randomised, crossover trial. Lancet. 2000;356(9237):1232–5.

    Article  CAS  PubMed  Google Scholar 

  90. Hille A, et al. Sodium butyrate enemas in the treatment of acute radiation-induced proctitis in patients with prostate cancer and the impact on late proctitis. A prospective evaluation. Strahlenther Onkol. 2008;184(12):686–92.

    Article  PubMed  Google Scholar 

  91. Leadon SA. Repair of DNA damage produced by ionizing radiation: a minireview. Semin Radiat Oncol. 1996;6(4):295–305.

    Article  CAS  PubMed  Google Scholar 

  92. Deveney CW, Lewis FR Jr, Schrock TR. Surgical management of radiation injury of the small and large intestine. Dis Colon Rectum. 1976;19(1):25–9.

    Article  CAS  PubMed  Google Scholar 

  93. Mann WJ. Surgical management of radiation enteropathy. Surg Clin North Am. 1991;71(5):977–90.

    Article  CAS  PubMed  Google Scholar 

  94. Eifel PJ, et al. Time course and incidence of late complications in patients treated with radiation therapy for FIGO stage IB carcinoma of the uterine cervix. Int J Radiat Oncol Biol Phys. 1995;32(5):1289–300.

    Article  CAS  PubMed  Google Scholar 

  95. Rotman M, et al. Prophylactic extended-field irradiation of para-aortic lymph nodes in stages IIB and bulky IB and IIA cervical carcinomas. Ten-year treatment results of RTOG 79-20. JAMA. 1995;274(5):387–93.

    Article  CAS  PubMed  Google Scholar 

  96. Haie C, et al. Is prophylactic para-aortic irradiation worthwhile in the treatment of advanced cervical carcinoma? Results of a controlled clinical trial of the EORTC radiotherapy group. Radiother Oncol. 1988;11(2):101–12.

    Article  CAS  PubMed  Google Scholar 

  97. Small W Jr, et al. Extended-field irradiation and intracavitary brachytherapy combined with cisplatin chemotherapy for cervical cancer with positive para-aortic or high common iliac lymph nodes: results of ARM 1 of RTOG 0116. Int J Radiat Oncol Biol Phys. 2007;68(4):1081–7.

    Article  CAS  PubMed  Google Scholar 

  98. Chautems RC, et al. Formaldehyde application for haemorrhagic radiation-induced proctitis: a clinical and histological study. Color Dis. 2003;5(1):24–8.

    Article  CAS  Google Scholar 

  99. Roche B, Chautems R, Marti MC. Application of formaldehyde for treatment of hemorrhagic radiation-induced proctitis. World J Surg. 1996;20(8):1092–4; discussion 1094-5.

    Article  CAS  PubMed  Google Scholar 

  100. Gami B, et al. How patients manage gastrointestinal symptoms after pelvic radiotherapy. Aliment Pharmacol Ther. 2003;18(10):987–94.

    Article  CAS  PubMed  Google Scholar 

  101. Viswanathan AN, et al. Radiation dose-volume effects of the urinary bladder. Int J Radiat Oncol Biol Phys. 2010;76(3 Suppl):S116–22.

    Article  PubMed  PubMed Central  Google Scholar 

  102. Marks LB, et al. The response of the urinary bladder, urethra, and ureter to radiation and chemotherapy. Int J Radiat Oncol Biol Phys. 1995;31(5):1257–80.

    Article  CAS  PubMed  Google Scholar 

  103. Viswanathan AN, et al. Complications of pelvic radiation in patients treated for gynecologic malignancies. Cancer. 2014;120(24):3870–83.

    Article  PubMed  Google Scholar 

  104. Nguyen TV, Petereit DG. High-dose-rate brachytherapy for medically inoperable stage I endometrial cancer. Gynecol Oncol. 1998;71(2):196–203.

    Article  CAS  PubMed  Google Scholar 

  105. McIntyre JF, et al. Ureteral stricture as a late complication of radiotherapy for stage IB carcinoma of the uterine cervix. Cancer. 1995;75(3):836–43.

    Article  CAS  PubMed  Google Scholar 

  106. Shao Y, Lu GL, Shen ZJ. Comparison of intravesical hyaluronic acid instillation and hyperbaric oxygen in the treatment of radiation-induced hemorrhagic cystitis. BJU Int. 2012;109(5):691–4.

    Article  PubMed  Google Scholar 

  107. Hazewinkel MH, et al. Prophylactic vesical instillations with 0.2% chondroitin sulfate may reduce symptoms of acute radiation cystitis in patients undergoing radiotherapy for gynecological malignancies. Int Urogynecol J. 2011;22(6):725–30.

    Article  PubMed  PubMed Central  Google Scholar 

  108. Smit SG, Heyns CF. Management of radiation cystitis. Nat Rev Urol. 2010;7(4):206–14.

    Article  PubMed  Google Scholar 

  109. Hughes LL, et al. Efficacy of radiotherapy for ovarian ablation: results of a breast intergroup study. Cancer. 2004;101(5):969–72.

    Article  PubMed  Google Scholar 

  110. Bese NS, et al. Ovarian ablation by radiation therapy: is it still an option for the ablation of ovarian function in endocrine responsive premenopausal breast cancer patients? Breast. 2009;18(5):304–8.

    Article  PubMed  Google Scholar 

  111. Nath R, et al. Code of practice for brachytherapy physics: report of the AAPM Radiation Therapy Committee Task Group No. 56. American Association of Physicists in Medicine. Med Phys. 1997;24(10):1557–98.

    Article  CAS  PubMed  Google Scholar 

  112. Kubo HD, et al. High dose-rate brachytherapy treatment delivery: report of the AAPM Radiation Therapy Committee Task Group No. 59. Med Phys. 1998;25(4):375–403.

    Article  CAS  PubMed  Google Scholar 

  113. Henkin RE, et al. ACR-ASTRO practice guideline for the performance of therapy with unsealed radiopharmaceutical sources. Clin Nucl Med. 2011;36(8):e72–80.

    Article  PubMed  Google Scholar 

  114. Batchelar DL, et al. Intraoperative ultrasound-based planning can effectively replace postoperative CT-based planning for high-dose-rate brachytherapy for prostate cancer. Brachytherapy. 2016;15(4):399–405.

    Article  PubMed  Google Scholar 

  115. Damato AL, Viswanathan AN. Magnetic resonance-guided gynecologic brachytherapy. Magn Reson Imaging Clin N Am. 2015;23(4):633–42.

    Article  PubMed  Google Scholar 

  116. Cormack RA. Quality assurance issues for computed tomography-, ultrasound-, and magnetic resonance imaging-guided brachytherapy. Int J Radiat Oncol Biol Phys. 2008;71(1 Suppl):S136–41.

    Article  PubMed  Google Scholar 

  117. Hellebust TP, et al. Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group: considerations and pitfalls in commissioning and applicator reconstruction in 3D image-based treatment planning of cervix cancer brachytherapy. Radiother Oncol. 2010;96(2):153–60.

    Article  PubMed  Google Scholar 

  118. Damato AL, et al. Redesign of process map to increase efficiency: reducing procedure time in cervical cancer brachytherapy. Brachytherapy. 2015;14(4):471–80.

    Article  PubMed  PubMed Central  Google Scholar 

  119. Wilkinson DA, Kolar MD. Failure modes and effects analysis applied to high-dose-rate brachytherapy treatment planning. Brachytherapy. 2013;12(4):382–6.

    Article  PubMed  Google Scholar 

  120. Kapur T, et al. 3-T MR-guided brachytherapy for gynecologic malignancies. Magn Reson Imaging. 2012;30(9):1279–90.

    Article  PubMed  PubMed Central  Google Scholar 

  121. Kharofa J, et al. 3-T MRI-based adaptive brachytherapy for cervix cancer: treatment technique and initial clinical outcomes. Brachytherapy. 2014;13(4):319–25.

    Article  PubMed  Google Scholar 

  122. Gill BS, et al. MRI-guided high-dose-rate intracavitary brachytherapy for treatment of cervical cancer: the University of Pittsburgh experience. Int J Radiat Oncol Biol Phys. 2015;91(3):540–7.

    Article  PubMed  Google Scholar 

  123. Damato AL, et al. A system to use electromagnetic tracking for the quality assurance of brachytherapy catheter digitization. Med Phys. 2014;41(10):101702.

    Article  PubMed  PubMed Central  Google Scholar 

  124. Wang W, et al. Evaluation of an active magnetic resonance tracking system for interstitial brachytherapy. Med Phys. 2015;42(12):7114–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  125. Dise J, et al. Development and evaluation of an automatic interstitial catheter digitization tool for adaptive high-dose-rate brachytherapy. Brachytherapy. 2015;14(5):619–25.

    Article  PubMed  Google Scholar 

  126. Damato AL, et al. Independent brachytherapy plan verification software: improving efficacy and efficiency. Radiother Oncol. 2014;113(3):420–4.

    Article  PubMed  Google Scholar 

  127. Damato AL, Viswanathan AN, Cormack RA. Validation of mathematical models for the prediction of organs-at-risk dosimetric metrics in high-dose-rate gynecologic interstitial brachytherapy. Med Phys. 2013;40(10):101711.

    Article  PubMed  PubMed Central  Google Scholar 

  128. Damato AL, Cormack RA, Viswanathan AN. Characterization of implant displacement and deformation in gynecologic interstitial brachytherapy. Brachytherapy. 2014;13(1):100–9.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiation Oncology, University of California Davis Health, Sacramento, CA, USA

    Brandon A. Dyer

  2. Department of Radiation Oncology, University of San Diego Health, San Diego, CA, USA

    Jyoti S. Mayadev

  3. Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Mitch Kamrava

  4. Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Scott Glaser & Sushil Beriwal

  5. Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Antonio Damato

Authors
  1. Brandon A. Dyer
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  2. Jyoti S. Mayadev
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  3. Mitch Kamrava
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  4. Scott Glaser
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  5. Sushil Beriwal
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  6. Antonio Damato
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Corresponding author

Correspondence to Jyoti S. Mayadev .

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Editors and Affiliations

  1. Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, USA

    Kevin Albuquerque

  2. Department of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USA

    Sushil Beriwal

  3. Department of Radiation Oncology, Johns Hopkins University, Baltimore, MD, USA

    Akila N. Viswanathan

  4. Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA

    Beth Erickson

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Dyer, B.A., Mayadev, J.S., Kamrava, M., Glaser, S., Beriwal, S., Damato, A. (2019). Interstitial Brachytherapy - Definitive and Adjuvant. In: Albuquerque, K., Beriwal, S., Viswanathan, A., Erickson, B. (eds) Radiation Therapy Techniques for Gynecological Cancers. Practical Guides in Radiation Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-01443-8_9

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