Abstract
For many acute and chronic pathologies, poor individual outcomes and overall statistics reflect the current unsatisfactory state of healthcare. Severe chronic pathologies such as cardiovascular disorders, diabetes, and cancer are treated after onset of the disease, frequently at near end stages. Replacing the current paradigm of reactive medical treatment with an innovative approach incorporating predictive, preventive and personalised medicine (PPPM) is crucial for modern healthcare. Cost-effective disease management and the central role of PPPM have been acknowledged as a priority by global and regional health-related organisations such as the United Nations, the European Union and the National Institutes of Health.
The prevalence and economic burden of the wound healing (WH) are not minor issues: in the USA alone, over $25 billion US are spent annually treating chronic wounds in 6.5 million patients. Problematic WH and chronic wounds may result from a broad spectrum of suboptimal health conditions and severe pathologies. Deficient WH reflects pathological processes and predicts severe diseases before their clinical manifestation. Both modifiable and non-modifiable risk factors make WH highly individual. Individualised patient profiling utilises systems medicine, predictive diagnostics, prevention and treatment tailored to the individual person, i.e. the innovative approaches of PPPM. Multilevel diagnostics employ comprehensive biomarker panels. Potential applications are multi-faceted: early diagnostics of related pathologies and disease predisposition, effective prevention and treatment of collateral pathologies, prediction and prognosis of postsurgical complications, improved individual outcomes in plastic surgery, etc.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Duarte AA, Mohsin S, Golubnitschaja O. Diabetes care in figures: current pitfalls and future scenario. EPMA J. 2018;9(2). 10.1007/s13167-018-0133-y.
Golubnitschaja O, Debald M, Yeghiazaryan K, Kuhn W, Pešta M, Costigliola V, Grech G. Breast cancer epidemic in the early 21st century: evaluation of risk factors, cumulative questionnaires and recommendations for preventive measures. Tumor Biol. 2016;37(10):12941–57. https://doi.org/10.1007/s13277-016-5168-x.
Golubnitschaja O. Three levels of prediction, prevention and individualised treatment algorithms to advance diabetes care: integrative approach. In: Mozaffari M, editor. The book “new strategies to advance pre/diabetes care: integrative approach by PPPM”. Dordrecht/Heidelberg/New York/London: Springer; 2013. p. 15–28. ISBN 978-94-007-5970-1.
Polivka J Jr, Altun I, Golubnitschaja O. Pregnancy associated breast cancer: the risky status quo and new concepts of predictive medicine. EPMA J. 2018;9(1):1–13. https://doi.org/10.1007/s13167-018-0129-7.
Vaz-Luis I, Lin NU, Keating NL, Barry WT, Winer EP, Freedman RA. Factors associated with early mortality among patients with de novo metastatic breast cancer: a population-based study. Oncologist. 2017;22:386. https://doi.org/10.1634/theoncologist.2016-0369.
Polivka J, Kralickova M, Polivka J, Kaiser C, Kuhn W, Golubnitschaja O. Mystery of the brain metastatic disease in breast cancer patients: improved patient stratification, disease prediction and targeted prevention on the horizon? EPMA J. 2017;8(2):119–27. https://doi.org/10.1007/s13167-017-0087-5.
Golubnitschaja O. Foreword, book series “advances in predictive, preventive and personalised medicine”. Dordrecht/Heidelberg/New York/London: Springer. http://www.springer.com/series/10051.
Sen CK, Gordillo GM, Roy S, Kirsner R, Lambert L, Hunt TK, et al. Human skin wounds: a major and snowballing threat to public health and economy. Wound Repair Regen. 2009;17(6):763–71.
Kunin A, Polivka J Jr, Moiseeva N, Golubnitschaja O. “Dry Mouth” and “Flammer” Syndromes - Neglected Risks in Adolescents and New Concepts by Predictive, Preventive and Personalised Approach. EPMA J. 2018;9(3):307–317. https://doi:10.1007/s13167-018-0145-7.
Avishai E, Yeghiazaryan K, Golubnitschaja O. Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine. EPMA J. 2017;8(1):23–33. https://doi.org/10.1007/s13167-017-0081-y.
Golubnitschaja O, Costigliola V, Grech G. EPMA World Congress: traditional forum in predictive, preventive and personalised medicine for multi-professional consideration and consolidation. EPMA J. 2017;8(Suppl):1–54. https://doi.org/10.1007/s13167-017-0108-4.
Bayat A, McGrouther DA, Ferguson MW. Skin scarring. BMJ. 2003;326(7380):88–92.
Bentov I, Reed MJ. Anesthesia, microcirculation, and wound repair in aging. Anesthesiology. 2014;120(3):760–72. https://doi.org/10.1097/ALN.0000000000000036.
Bhargava M, Viken KJ, Dey S, Steinbach MS, Wu B, Jagtap PD, Higgins L, Panoskaltsis-Mortari A, Weisdorf DJ, Kumar V, Arora M, Bitterman PB, Ingbar DH, Wendt CH. Proteome profiling in lung injury after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2016;22(8):1383–90. https://doi.org/10.1016/j.bbmt.2016.04.021.
Al-Shaqsi S, Al-Bulushi T. Cutaneous scar prevention and management: overview of current therapies. Sultan Qaboos Univ Med J. 2016;16(1):e3–8. https://doi.org/10.18295/squmj.2016.16.01.002.
Bhattacharya S, Aggarwal R, Singh VP, Ramachandran S, Datta M. Downregulation of miRNAs during delayed wound healing in diabetes: role of dicer. Mol Med. 2015;21(1):847–60. https://doi.org/10.2119/molmed.2014.00186.
Brady NJ, Chuntova P, Schwertfeger KL. Macrophages: regulators of the inflammatory microenvironment during mammary gland development and breast cancer. Mediat Inflamm. 2016;2016:4549676. https://doi.org/10.1155/2016/4549676.
Zubor P, Gondova A, Polivka J Jr, Kasajova P, Konieczka K, Danko J, Golubnitschaja O. Breast cancer and Flammer syndrome: any symptoms in common for prediction, prevention and personalised medical approach? EPMA J. 2017;8(2):129–40. https://doi.org/10.1007/s13167-017-0089-3.
Bubnov R, Polivka J Jr, Zubor P, Koniczka K, Golubnitschaja O. Pre-metastatic niches in breast cancer: are they created by or prior to the tumour onset? Flammer Syndrome relevance to address the question. EPMA J. 2017;8(2):141–57. https://doi.org/10.1007/s13167-017-0092-8.
Kunin A, Polivka J Jr, Moiseeva N, Golubnitschaja O. “Dry Mouth” and “Flammer” Syndromes - Neglected Risks in Adolescents and New Concepts by Predictive, Preventive and Personalised Approach. EPMA J. 2018;9(3):307–317. https://doi:10.1007/s13167-018-0145-7].
Golubnitschaja O, Jaksche A, Moenkemann H, Yeghiazaryan K, Karl SE, Schild HH, Löffler KU. Molecular imaging system for possible prediction of active retinopathy in patients with Diabetes mellitus. Amino Acids. 2005;28:229–37.
Yeghiazaryan K, Flammer J, Orgül S, Wunderlich K, Golubnitschaja O. Vasospastic individuals demonstrate significant similarity to glaucoma patients as revealed by gene expression profiling in circulating leukocytes. Mol Vis. 2009;15:2339–48.
Stolzenburg-Veeser L and Golubnitschaja O. Mini-encyclopaedia of the wound healing - Opportunities for integrating multi-omic approaches into medical practice. Journal of Proteomics. 2018;188:71-84. https://doi:10.1016/j.jprot.2017.07.017.
Eming SA, Martin P, Tomic-Canic M. Wound repair and regeneration: mechanisms, signaling, and translation. Sci Transl Med. 2014;6(265):265sr6. https://doi.org/10.1126/scitranslmed.3009337.
Luan A, Hu MS, Leavitt T, Brett EA, Wang KC, Longaker MT, Wan DC. Noncoding RNAs in wound healing: a new and vast frontier. Adv Wound Care (New Rochelle). 2018;7(1):19–27. https://doi.org/10.1089/wound.2017.0765.
Lindley LE, Stojadinovic O, Pastar I, Tomic-Canic M. Biology and biomarkers for wound healing. Plast Reconstr Surg. 2016;138(3 Suppl):18S–28S. https://doi.org/10.1097/PRS.0000000000002682.
Csősz É, Deák E, Kalló G, Csutak A, Tőzsér J. Diabetic retinopathy: proteomic approaches to help the differential diagnosis and to understand the underlying molecular mechanisms. J Proteome. 2017;150:351–8. https://doi.org/10.1016/j.jprot.2016.06.034.
Darby IA, Laverdet B, Bonté F, Desmoulière A. Fibroblasts and myofibroblasts in wound healing. Clin Cosmet Investig Dermatol. 2014;7:301–11. https://doi.org/10.2147/CCID.S50046.
MacLeod AS, Mansbridge JN. The innate immune system in acute and chronic wounds. Adv Wound Care. 2016;5(2):65–78. https://doi.org/10.1089/wound.2014.0608.
Martin P, Nunan R. Cellular and molecular mechanisms of repair in acute and chronic wound healing. Br J Dermatol. 2015;173(2):370–8. https://doi.org/10.1111/bjd.13954.
Leonardi GC, Accardi G, Monastero R, Nicoletti F, Libra M. Ageing: from inflammation to cancer. Immun Ageing. 2018;15(1):1. https://doi.org/10.1186/s12979-017-0112-5.
Mikesh LM, Aramadhaka LR, Moskaluk C, Zigrino P, Mauch C, Fox JW. Proteomic anatomy of human skin. J Proteome. 2013;84:190–200. https://doi.org/10.1016/j.jprot.2013.03.019.
Golubnitschaja O, Yeghiazaryan K, Stricker H, Trog D, Schild HH, Berliner L. Patients with hepatic breast cancer metastases demonstrate highly specific profiles of matrix metalloproteinases MMP-2 and MMP-9 after SIRT treatment as compared to other primary and secondary liver tumours. BMC Cancer. 2016;16:357. https://doi.org/10.1186/s12885-016-2382-2.
Molnar JA, Underdown MJ, Clark WA. Nutrition and chronic wounds. Adv Wound Care. 2014;3(11):663–81. https://doi.org/10.1089/wound.2014.0530.
Nauta TD, van Hinsbergh VW, Koolwijk P. Hypoxic signaling during tissue repair and regenerative medicine. Int J Mol Sci. 2014;15(11):19791–815. https://doi.org/10.3390/ijms151119791.
Cazander G, Jukema GN, Nibbering PH. Complement activation and inhibition in wound healing. Clin Dev Immunol. 2012;2012:534291. https://doi.org/10.1155/2012/534291.
George AL, Bangalore-Prakash P, Rajoria S, et al. Endothelial progenitor cell biology in disease and tissue regeneration. J Hematol Oncol. 2011;4:24. https://doi.org/10.1186/1756-8722-4-24.
Falanga V. Wound healing and its impairment in the diabetic foot. Lancet. 2005;366(9498):1736–43.
Ren Y, Gu G, Yao M, Driver VR. Role of matrix metalloproteinases in chronic wound healing: diagnostic and therapeutic implications. Chin Med J. 2014;127(8):1572–81.
Franco C, Hess S. Recent proteomic advances in developmental, regeneration, and cancer governing signaling pathways. Proteomics. 2015;15(5–6):1014–25. https://doi.org/10.1002/pmic.201400368.
Cebioglu M, Schild HH, Golubnitschaja O. Cancer predisposition in diabetics: risk factors considered for predictive diagnostics and targeted preventive measures. EPMA J. 2010;1(1):130–7. https://doi.org/10.1007/s13167-010-0015-4.
Rieger S, Zhao H, Martin P, Abe K, Lisse TS. The role of nuclear hormone receptors in cutaneous wound repair. Cell Biochem Funct. 2015;33(1):1–13. https://doi.org/10.1002/cbf.3086.
Jiang M, Qiu J, Zhang L, et al. Changes in tension regulates proliferation and migration of fibroblasts by remodeling expression of ECM proteins. Exp Ther Med. 2016;12(3):1542–50. https://doi.org/10.3892/etm.2016.3497.
Kunin A, Polivka J Jr, Moiseeva N, Golubnitschaja O. “Dry Mouth” and “Flammer” Syndromes - Neglected Risks in Adolescents and New Concepts by Predictive, Preventive and Personalised Approach. EPMA J. 2018;9(3):307–317. https://doi:10.1007/s13167-018-0145-7].
Ahn C, Mulligan P, Salcido RS. Smoking-the bane of wound healing: biomedical interventions and social influences. Adv Skin Wound Care. 2008;21(5):227–36. quiz 237–8.
Szabo G, Mandrekar P. A recent perspective on alcohol, immunity, and host defense. Alcohol Clin Exp Res. 2009;33(2):220–32.
Kiecolt-Glaser JK, Marucha PT, Mercado AM, Malarkey WB, Glaser R. Slowing of wound healing by psychological stress. Lancet. 1995;346(8984):1194–6.
Demling RH. Nutrition, anabolism, and the wound healing process: an overview. Eplasty. 2009;9:e9.
Konieczka K, Ritch R, Traverso CE, Kim DM, Kook MS, Gallino A, Golubnitschaja O, Erb C, Reitsamer HA, Kida T, Kurysheva N, Yao K. Flammer syndrome. EPMA J. 2014;5(1):11. https://doi.org/10.1186/1878-5085-5-11.
Golubnitschaja O. Feeling cold and other underestimated symptoms in breast cancer: anecdotes or individual profiles for advanced patient stratification? EPMA J. 2017;8(1):17–22. https://doi.org/10.1007/s13167-017-0086-6.
Golubnitschaja O, Filep N, Yeghiazaryan K, Blom HJ, Hofmann-Apitius M, Kuhn W. Multi-omic approach decodes paradoxes of the triple-negative breast cancer: lessons for predictive, preventive and personalised medicine. Amino Acids. 2018;50:383. https://doi.org/10.1007/s00726-017-2524-0.
Kapinova A, Kubatka P, Zubor P, Golubnitschaja O, Dankova Z, Uramova S, Pilchova I, Caprnde M, Opatrilova R, Richnavsky J, Kruzliak P, Danko J. The hypoxia-responsive long non-coding RNAs may impact on the tumor biology and subsequent management of breast cancer. Biomed Pharmacother. 2018;99:51–8. https://doi.org/10.1016/j.biopha.2017.12.104.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Golubnitschaja, O., Veeser, L.S., Avishai, E., Costigliola, V. (2019). Wound Healing: Proof-of-Principle Model for the Modern Hospital: Patient Stratification, Prediction, Prevention and Personalisation of Treatment. In: Latifi, R. (eds) The Modern Hospital. Springer, Cham. https://doi.org/10.1007/978-3-030-01394-3_33
Download citation
DOI: https://doi.org/10.1007/978-3-030-01394-3_33
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-01393-6
Online ISBN: 978-3-030-01394-3
eBook Packages: MedicineMedicine (R0)