Corneal Endothelium Regeneration: Future Prospects

  • Wei-Ting Ho
  • Hsin-Yu Liu
  • Fung-Rong Hu
  • I-Jong WangEmail author
Part of the Essentials in Ophthalmology book series (ESSENTIALS)


Corneal endothelial dysfunction causes corneal edema and severe visual impairments that may lead to permanent blindness. Although corneal endothelial keratoplasty is currently the treatment-of-choice to restore vision, it faces several difficulties, including worldwide shortage of donor corneas, progressive loss of endothelial cells after surgery, and extensive damage of endothelial cells during surgical manipulation. With further understanding of the corneal endothelial cell biology and advances in the field of pharmacological treatment, tissue engineering, cell or stem cell therapy, different strategies have been developed to treat corneal endothelial disorders.


Corneal endothelium Regeneration Corneal transplantation Tissue engineering Cell therapy Stem cell 


Conflict of Interest

Wei-Ting Ho, Hsin-Yu Liu, Fung-Rong Hu and I-Jong Wang declare that they have no conflict of interest.

Informed Consent

No human studies were carried out by the authors for this article.

Animal Studies

All institutional and national guidelines for the care and use of laboratory animals were followed.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Wei-Ting Ho
    • 1
  • Hsin-Yu Liu
    • 2
  • Fung-Rong Hu
    • 2
    • 3
  • I-Jong Wang
    • 2
    • 3
    Email author
  1. 1.Department of OphthalmologyFar Eastern Memorial HospitalNew Taipei CityTaiwan
  2. 2.Department of OphthalmologyNational Taiwan University HospitalTaipeiTaiwan
  3. 3.College of Medicine, National Taiwan UniversityTaipeiTaiwan

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