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Cell Therapy Using Ex Vivo Cultured Limbal Cells: CLET and Equivalent

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Corneal Regeneration

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

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Abstract

Cell therapy for treatment of corneal lesions, with associated corneal (limbal) stem cell deficiency due to ocular burns, has recently gained regulatory approval from the European Medicines Agency (EMA), and it is the first choice to restore corneal surface integrity when corneal epithelial stem cells have been lost. LSCD can be due to a number of genetic, inflammatory, or traumatic disorders and frequently results in mono- or binocular blindness. In this chapter, we will review different limbal stem cell therapies for LSCD. We will do so by considering the epidemiology of LSCD and different types of cultivated limbal stem cell treatments. Alternative treatments will also be briefly reviewed. Potential advantages, and pitfalls, of autologous versus allogenic limbal stem cell transplantation will be considered.

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Authors and Affiliations

  1. San Raffaele Hospital, Department of Ophthalmology—Cornea and Ocular Surface, Milan, Italy

    Paolo Rama & Giulio Ferrari

Authors
  1. Paolo Rama
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  2. Giulio Ferrari
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Corresponding author

Correspondence to Paolo Rama .

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Editors and Affiliations

  1. Miguel Hernández University , Alicante, Spain

    Jorge L. Alió

  2. Vissum-Instituto Oftalmologico de Alica, University Miguel Hernandez, Alicante, Alicante, Spain

    Jorge L. Alió del Barrio

  3. Vissum Corporation, Madrid, Spain

    Francisco Arnalich-Montiel

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Rama, P., Ferrari, G. (2019). Cell Therapy Using Ex Vivo Cultured Limbal Cells: CLET and Equivalent. In: Alió, J., Alió del Barrio, J., Arnalich-Montiel, F. (eds) Corneal Regeneration . Essentials in Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-030-01304-2_15

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  • DOI: https://doi.org/10.1007/978-3-030-01304-2_15

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-01303-5

  • Online ISBN: 978-3-030-01304-2

  • eBook Packages: MedicineMedicine (R0)

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