Rectal Cancer: Watch and Wait
The management of rectal cancer has become increasingly complex. In the 15–20% of patients who achieve a pathologic complete response to neoadjuvant chemoradiation therapy, long-term local and distant tumor control is excellent. Based on these excellent outcomes, interest has grown for an organ-preserving watch and wait approach with selective surgery for patients exhibiting clinical complete response. While there is encouraging emerging data, further validation through rigorous prospective trials is needed before a nonoperative strategy can be routinely offered.