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Biomolecular Targets of Oxyprenylated Phenylpropanoids and Polyketides

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Progress in the Chemistry of Organic Natural Products 108

Part of the book series: Progress in the Chemistry of Organic Natural Products ((POGRCHEM,volume 108))

Abstract

Oxyprenylated secondary metabolites (e.g. phenylpropanoids and polyketides) represent a rare class of natural compounds. Over the past two decades, this group of phytochemicals has become a topic of intense research activity by several teams worldwide due to their in vitro and in vivo pharmacological activities, and to their great therapeutic and nutraceutical potential for the chemoprevention of acute and chronic diseases affecting humans. Such investigations have provided evidence that oxyprenylated secondary metabolites are able to interact with several biological targets at different levels accounting for their observed anticarcinogenic, anti-inflammatory, neuroprotective, immunomodulatory, antihypertensive, and metabolic effects. The aim of the present contribution is to provide a detailed survey of the so far reported data on the capacities of selected oxyprenylated phenylpropanoids and polyketides to trigger receptors, enzymes, and other types of cellular factors for which they exhibit a high degree of affinity and therefore evoke specific responses. With respect to the rather small amounts of these compounds available from natural sources, their chemical synthesis is also highlighted.

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Authors and Affiliations

  1. Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, Chieti Scalo, Italy

    Serena Fiorito, Francesco Epifano, Francesca Preziuso, Vito Alessandro Taddeo & Salvatore Genovese

Authors
  1. Serena Fiorito
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  2. Francesco Epifano
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  3. Francesca Preziuso
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  4. Vito Alessandro Taddeo
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  5. Salvatore Genovese
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Corresponding author

Correspondence to Francesco Epifano .

Editor information

Editors and Affiliations

  1. College of Pharmacy, The Ohio State University, Columbus, OH, USA

    A. Douglas Kinghorn

  2. Institute of Organic Chemistry, Johannes Kepler University, Linz, Austria

    Heinz Falk

  3. UCL School of Pharmacy, University College London, Research, London, UK

    Simon Gibbons

  4. Grad. School of Pharmaceutical Science, Hokkaido University, Fukuoka, Japan

    Jun'ichi Kobayashi

  5. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan

    Yoshinori Asakawa

  6. School of Pharmaceutical Sciences, South-Central Univ. for Nationalities, Wuhan, China

    Ji-Kai Liu

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Fiorito, S., Epifano, F., Preziuso, F., Taddeo, V.A., Genovese, S. (2019). Biomolecular Targets of Oxyprenylated Phenylpropanoids and Polyketides. In: Kinghorn, A., Falk, H., Gibbons, S., Kobayashi, J., Asakawa, Y., Liu, JK. (eds) Progress in the Chemistry of Organic Natural Products 108. Progress in the Chemistry of Organic Natural Products, vol 108. Springer, Cham. https://doi.org/10.1007/978-3-030-01099-7_2

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