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Roles and Functions of the Unconventional Prefoldin URI

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Prefoldins: the new chaperones

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1106))

Abstract

Almost 15 years ago, the URI prefoldin-like complex was discovered by Krek and colleagues in immunoprecipitation experiments conducted in mammalian cells with the aim of identifying new binding partners of the E3 ubiquitin-protein ligase S-phase kinase-associated protein 2 (SKP2) (Gstaiger et al. Science 302(5648):1208–1212, 2003). The URI prefoldin-like complex is a heterohexameric chaperone complex comprising two α and four β subunits (α2β4). The α subunits are URI and STAP1, while the β subunits are PFDN2, PFDN6, and PFDN4r, one of which is probably present in duplicate. Elucidating the roles and functions of these components in vitro and in vivo will help to clarify the mechanistic behavior of what appears to be a remarkably important cellular machine.

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Acknowledgments

This work was supported by the Spanish Ministry of Economy and Competitiveness, and co-funded by ERDF-EU (FEDER, SAF2016-76598-R).

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  1. Cancer Cell Biology Programme, Growth factors, Nutrients and Cancer Group, Centro Nacional Investigaciones Oncológicas, CNIO, Madrid, Spain

    Almudena Chaves-Pérez, Sebastian Thompson & Nabil Djouder

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  1. Almudena Chaves-Pérez
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  2. Sebastian Thompson
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  3. Nabil Djouder
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Correspondence to Nabil Djouder .

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  1. Centro Nacional de Investigaciones Oncológicas, CNIO, Madrid, Spain

    Nabil Djouder

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Chaves-Pérez, A., Thompson, S., Djouder, N. (2018). Roles and Functions of the Unconventional Prefoldin URI. In: Djouder, N. (eds) Prefoldins: the new chaperones. Advances in Experimental Medicine and Biology, vol 1106. Springer, Cham. https://doi.org/10.1007/978-3-030-00737-9_7

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