Roles and Functions of the Unconventional Prefoldin URI
Almost 15 years ago, the URI prefoldin-like complex was discovered by Krek and colleagues in immunoprecipitation experiments conducted in mammalian cells with the aim of identifying new binding partners of the E3 ubiquitin-protein ligase S-phase kinase-associated protein 2 (SKP2) (Gstaiger et al. Science 302(5648):1208–1212, 2003). The URI prefoldin-like complex is a heterohexameric chaperone complex comprising two α and four β subunits (α2β4). The α subunits are URI and STAP1, while the β subunits are PFDN2, PFDN6, and PFDN4r, one of which is probably present in duplicate. Elucidating the roles and functions of these components in vitro and in vivo will help to clarify the mechanistic behavior of what appears to be a remarkably important cellular machine.
KeywordsGimC Prefoldin-like URI RNA polymerase II R2TP complex Chaperone proteostasis genetically engineered mouse models (GEMMs) cancer environmental factors stress signaling mTOR PP1 Erα OGT AhR parafibromin
This work was supported by the Spanish Ministry of Economy and Competitiveness, and co-funded by ERDF-EU (FEDER, SAF2016-76598-R).
- Brandt M, Grazioso TP, Fawal MA, Tummala KS, Torres-Ruiz R, Rodriguez-Perales S et al (2017) mTORC1 inactivation promotes colitis-induced colorectal cancer but protects from APC loss-dependent tumorigenesis. Cell Metab 19Google Scholar
- Taneja SS, Ha S, Swenson NK, Torra IP, Rome S, Walden PD et al (2004) ART-27, an androgen receptor coactivator regulated in prostate development and cancer. J Biol Chem 7Google Scholar
- Umemura A, Park EJ, Taniguchi K, Lee JH, Shalapour S, Valasek MA et al (2014) Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metab 4Google Scholar