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Role of the PAQosome in Regulating Arrangement of Protein Quaternary Structure in Health and Disease

  • Marie-Soleil Gauthier
  • Philippe Cloutier
  • Benoit CoulombeEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1106)

Abstract

The PAQosome, formerly known as the R2TP/PFDL complex, is an eleven-subunit cochaperone complex that assists HSP90 in the assembly of numerous large multisubunit protein complexes involved in essential cellular functions such as protein synthesis, ribosome biogenesis, transcription, splicing, and others. In this review, we discuss possible mechanisms of action and role of phosphorylation in the assembly of client complexes by the PAQosome as well as its potential role in cancer, ciliogenesis and ciliopathies.

Keywords

R2TP Prefoldin-like PAQosome Chaperone Protein complex assembly Protein network Cancer Cilium Ciliopathies Phosphorylation Interactome Quaternary structure arrangement UXT URI1 PDRG1 

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Authors and Affiliations

  • Marie-Soleil Gauthier
    • 1
  • Philippe Cloutier
    • 1
  • Benoit Coulombe
    • 1
    • 2
    Email author
  1. 1.Institut de Recherches Cliniques de MontréalQCCanada
  2. 2.Department of Biochemistry and Molecular MedicineUniversité de MontréalQCCanada

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