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Interaction of Particles and Pathogens with Biological Membranes

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Physics of Biological Membranes

Abstract

Biological membranes are both barriers and communication interfaces of cells. Transport across membranes is therefore essential for life. It encompasses both endocytotic and exocytotic processes important for cell function, but also the invasion of cells by parasites and viruses, and targeted drug delivery. Whereas interactions on the molecular scale are important for particles with sizes comparable with the thickness of the membrane, the mechanical properties of the entire membrane determine its interaction with larger particles. We focus here on large particles and parasites and discuss wrapping of single particles by homogeneous and complex membranes. Both solid particles with various shapes as well as soft particles are considered. Membrane-mediated interactions of many particles lead to aggregation and tubulation. Finally, active biological mechanisms are shown to support the invasion of parasites, such as the malaria parasite, and to drive phagocytosis.

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Acknowledgements

Our research on the interaction of particles with biological membranes has been supported by the EU FP7 NMP collaborative project PreNanoTox (309666).

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Authors and Affiliations

  1. Forschungzentrum Jülich, Theoretical Soft Matter and Biophysics, Institute of Complex Systems and Institute for Advanced Simulation, Jülich, Germany

    Thorsten Auth & Gerhard Gompper

  2. National University of Singapore, Mechanobiology Institute, Singapore, Singapore

    Sabyasachi Dasgupta

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  1. Thorsten Auth
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Correspondence to Thorsten Auth .

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  1. PhysicoChimie Curie (UMR CNRS 168), Institut Curie, Paris, France

    Patricia Bassereau

  2. PhysicoChimie Curie (UMR CNRS 168), Institut Curie, Paris, France

    Pierre Sens

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Auth, T., Dasgupta, S., Gompper, G. (2018). Interaction of Particles and Pathogens with Biological Membranes. In: Bassereau, P., Sens, P. (eds) Physics of Biological Membranes. Springer, Cham. https://doi.org/10.1007/978-3-030-00630-3_17

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