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Physics of Biological Membranes pp 421–469Cite as

Common Energetic and Mechanical Features of Membrane Fusion and Fission Machineries

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Abstract

Membrane fusion and fission reactions are two antagonistic processes involved in several important biological functions, including intracellular and intercellular communication, viral infection, and the maintenance of shape and function of the mitochondrial and endoplasmic reticulum networks. Both reactions imply transient membrane remodeling events requiring a high energy input to overcome the intrinsic stability of the membrane lipid bilayer structure. This energy is provided by specialized proteins that accompany membranes on their path to fusion/fission. In this chapter, we present the physical principles of membrane fusion and fission reactions, review the several mechanisms used by specific proteins to mediate membrane fusion and fission, and emphasize the common strategies employed by these proteins to manipulate lipid bilayers during fusion/fission events.

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Authors and Affiliations

  1. Institute of Psychiatry and Neuroscience, UMR S-894 INSERM-Paris Descartes University, Paris, France

    David Tareste

  2. Biochemistry Department, Geneva University, Geneva, Switzerland

    Aurélien Roux

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  1. PhysicoChimie Curie (UMR CNRS 168), Institut Curie, Paris, France

    Patricia Bassereau

  2. PhysicoChimie Curie (UMR CNRS 168), Institut Curie, Paris, France

    Pierre Sens

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Tareste, D., Roux, A. (2018). Common Energetic and Mechanical Features of Membrane Fusion and Fission Machineries. In: Bassereau, P., Sens, P. (eds) Physics of Biological Membranes. Springer, Cham. https://doi.org/10.1007/978-3-030-00630-3_16

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