Abstract
Flavonoids are naturally occurring polyphenolic compounds widely distributed in the plant kingdom. These compounds have long been recognized to possess a broad spectrum of biological activities, such as antioxidant, anti-inflammatory, hepatoprotector, antibacterial, antiviral, antidiabetic, antiproliferative and anticarcinogenic. Although they are not regarded as nutrients, they are important constituents of the human diet. Flavonoids are present in leafy vegetables, apples, onions, broccoli, berries, citrus fruits, grapes and soybeans, also in tea, chocolate and red wine. Many studies have demonstrated that a high intake of flavonoids is associated with a reduced risk of cardiovascular disease, cancer and neurodegenerative disorders. In recent years, there has been an increasing progress in the elucidation of the mechanisms through which flavonoids exert their biological activities. In addition to the already known free radical scavenging effect, flavonoids exert beneficial effects through the interaction with nuclear transcription factor kappa-B, activator protein 1, Janus kinases and phosphatidylinositol-3 kinase signaling pathways. This chapter focuses on recent findings on the role of flavonoids as modulators of inflammation and on cell signaling pathways.
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- 4′-HW:
-
4′-hydroxywogonin
- 5B:
-
(E)-3-(3,4-dimethoxyphenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl) prop-2-en-1-one
- 67LR:
-
67-kDa laminin receptor
- AA:
-
Arachidonic acid
- Afla:
-
Amentoflavone
- Akt:
-
Protein kinase B
- Alp:
-
Alpinetin
- Amp:
-
Ampelopsin
- AMPK:
-
Adenosine monophosphate-activated protein kinase
- AP-1:
-
Activator protein-1
- Api:
-
Apigenin
- Ast:
-
Astragalin
- BBB:
-
Blood-brain barrier
- BMDM:
-
Bone marrow-derived macrophages
- C3G:
-
Cyanidin-3-O-glucoside
- CAMs:
-
Cell surface adhesion molecules
- CAT:
-
Catalase
- Cat:
-
Catechin
- Chr:
-
Chrysin
- CNS:
-
Central nervous system
- COMT:
-
Catechol-O-methyltransferase
- COX:
-
Cyclooxygenase
- Dai:
-
Daidzein
- DMH:
-
1,2-dimethyl hydrazine
- DNA:
-
Deoxyribonucleic acid
- EGCG:
-
Epigallocatechin-3-gallate
- EGF:
-
Epidermal growth factor
- eNOS:
-
Endothelial nitric oxide synthase
- EpRE:
-
Electrophile-responsive element
- ERK:
-
Extracellular signal-regulated kinases
- Eup:
-
Eupatilin
- Fis:
-
Fisetin
- FlkA:
-
Flavokawain A
- Gen:
-
Genisteína
- GEN-27:
-
5-hydroxy-7-[2-hydroxy-3-(piperidin-1-yl) propoxy]-3-{4-[2-hydroxy-3-(piperidin-1-yl) propoxy] phenyl}-4H-chromen-4-one
- GPx:
-
Glutathione peroxidase
- HaCaT cells:
-
Human keratinocytes
- hAs:
-
Human astrocytes
- hBMEC:
-
Injured human brain microvascular endothelial cell
- HCT116:
-
Human colon tumour
- HGF:
-
Human gingival fibroblasts
- HIF-1α:
-
Hypoxia-inducible factor 1-α
- HMGB:
-
High-mobility group box
- HMGB1:
-
High-mobility group box 1 protein
- HO-1:
-
Heme oxygenase-1
- hPBMCs:
-
Human peripheral blood mononuclear cells
- HUVEC:
-
Human umbilical vein endothelial cell
- Ibc:
-
Isobavachalcone
- Ica:
-
Icariin
- ICAM:
-
Intercellular adhesion molecule
- ICT:
-
3,5,7-trihydroxy-4′-methoxy-8-(3-hydroxy-3-methylbutyl)-flavone
- IFN:
-
Interferon
- Ig:
-
Immunoglobulin
- IKK:
-
IκB kinase
- IL:
-
Interleukin
- iNOS:
-
Inducible nitric oxide synthase
- IRAK:
-
IL-1 receptor-associated kinase
- IκB:
-
Inhibitor of kappa-B
- JAK:
-
Janus kinase
- JNK:
-
c-Jun N-terminal kinases
- L2H17:
-
1-(3,4-Dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one
- LicoC:
-
Licochalcone C
- LOX:
-
Lypooxygenase
- LPH:
-
Lactase phlorizin hydrolase
- LPS:
-
Lipopolysaccharide
- LT:
-
Leukotriene
- Lut:
-
Luteolin
- Mal:
-
Malvidin
- Mal3OG:
-
Malvidin-3-O-glucoside
- MALP-2:
-
Macrophage-activating lipopeptide 2-kDa
- MAPK:
-
Mitogen-activated protein kinase
- MCAO:
-
Middle cerebral artery occlusion
- MCP:
-
Monocyte chemoattractant protein
- MIP:
-
Macrophage inflammatory protein
- mMEC:
-
Mouse mammary epithelial cell
- MMP:
-
Matrix metalloproteinase
- MPO:
-
Myeloperoxidase
- mRNA:
-
Messenger ribonucleic acid
- Nag:
-
Naringin
- Nar:
-
Naringenin
- NF-κB:
-
Nuclear factor kappa B
- nNOS:
-
Neuronal NOS
- NO:
-
Nitric oxide
- NOS:
-
Nitric oxide synthase
- Nrf2:
-
Nuclear factor-erythroid-related factor 2
- NSAIDs:
-
Non-steroidal anti-inflammatory drugs
- Ono:
-
Ononin
- OroA:
-
Oroxylin A
- OVA:
-
Ovalbumin
- PAI-1:
-
Plasminogen activator inhibitor 1
- PCB:
-
Polychlorinated biphenyl
- PDGF:
-
Platelet-derived growth factor
- Pel:
-
Pelargonidin
- Peo:
-
Peonidin
- PG:
-
Prostaglandin
- Phl:
-
Phloretin
- PI3K:
-
Phosphatidylinositol-3 kinase
- Pin:
-
Pinocembrin
- PKC:
-
Protein kinase C
- poly[I:C]:
-
Polyriboinosinic polyribocytidylic acid
- PPAR:
-
Peroxisome proliferator-activated receptor
- Pru:
-
Prunetin
- Pue:
-
Puerarin
- Quer:
-
Quercetin
- RAGE:
-
Receptor for advanced glycation end products
- RANTES:
-
Regulated upon activation normal T-cell expressed and secreted
- ROS:
-
Reactive oxygen species
- Rut:
-
Rutin
- SG:
-
Sophoraflavanone
- SIRT:
-
Sirtuin
- SOCS:
-
Suppressors of cytokine signaling
- SOD:
-
Superoxide dismutase
- STATs:
-
Signal transducer and activator of transcription
- SULTs:
-
Sulfotransferases
- TACR-1:
-
Tachykinin receptor 1
- Tax:
-
Taxifolin
- TBARS:
-
Thiobarbituric acid reactive substances
- TGF:
-
Tumour growth factor
- TLR:
-
Toll-like receptor
- TNF-α:
-
Tumour necrosis factor-α
- Tollip:
-
Toll-interacting protein
- Tri:
-
Tricin
- TX:
-
Thromboxane
- UgoM:
-
Ugonin M
- UGTs:
-
Uridine 5′-diphospho-glucuronosyltransferases
- UV:
-
Ultraviolet
- VCAM:
-
Vascular cell adhesion molecule
- VEGF:
-
Vascular endothelial growth factor
- Vel:
-
Velutin
- Vix:
-
Vitexin
- Won:
-
Wogonin
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Muschietti, L.V., Ulloa, J.L., Redko, F.D. (2018). The Role of Flavonoids as Modulators of Inflammation and on Cell Signaling Pathways. In: Cechinel Filho, V. (eds) Natural Products as Source of Molecules with Therapeutic Potential. Springer, Cham. https://doi.org/10.1007/978-3-030-00545-0_5
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