Extranodal Localization of Aggressive Lymphoma

  • Jeremy S. AbramsonEmail author
  • Armando López-Guillermo
Part of the Hematologic Malignancies book series (HEMATOLOGIC)


Aggressive lymphomas commonly involve both nodal and extranodal locations. DLBCL may primarily involve discrete extranodal locations and be characterized by distinct biology, clinical presentation, and treatment considerations. Though any extranodal site in the body may be involved by DLBCL, unique consideration is warranted for DLBCLs which primarily involve the GI tract, bone, mediastinum, testis, breast, and skin. These entities will be reviewed, including approach to staging, prognosis, and management, including the role of radiation therapy and CNS prophylaxis.


Diffuse large B-cell lymphoma Extranodal lymphoma Primary bone lymphoma Primary testicular lymphoma Primary mediastinal B-cell lymphoma 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Massachusetts General Hospital Cancer CenterBostonUSA
  2. 2.Hospital ClínicIDIBAPSBarcelonaSpain

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