Abstract
Germ cell tumors are relatively uncommon, accounting for only 1% of male malignancies in the United States. The highest worldwide incidence is in Scandinavian countries; by contrast, testicular cancer is rare in African Americans. The primary age group is 15–l35 for nonseminomatous tumors and a decade older for seminoma. Thus, the potential for loss of productive years of life has always made testis cancer important both medically and economically.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Einhorn LH (1981) Testicular cancer: A model for a curable neoplasm. Cancer Research 41:3275–3280
Einhorn LH (1990) Treatment of testicular cancer: A new and improved model. J Clin Oncol 8:1777–1781
Bosl GJ, Motzer RJ (1997) Testicular germ cell cancer. NEJM 337:242–253
Li MC, Whitmore WF, Golbey R et al (1960) Effects of combined drug therapy on metastatic cancer of the testis. JAMA 174:145–153
Samuels ML, Lanzotti VJ, Holoye PY et al (1976) Combination chemotherapy in germinal cell tumors. Cancer Treat Rev 3:185–204
Rosenberg B, VanCamp L, Krigas T (1965) Inhibition of cell division in e. coli by electrolysis products from a platinum electrode. Nature 205:678–699
Higby DJ, Wallace HJ, Albert DJ et al (1974) Diamminedichloroplatinum: A phase I study showing responses in testicular and other tumors. Cancer 33:1219–1225
Einhorn LH, Donohue JP (1977) Combination chemotherapy with cis-diam- minedichloroplatinum, vinblastine, and bleomycin in disseminated testicular cancer. Ann Int Med 87:293–298
Einhorn LH, Williams SD, Troner M, Greco FA, Birch R (1981) The rise of maintenance therapy in disseminated testicular cancer: A Southeastern Cancer Study Group Protocol. NEJM 305:717–731
Fitzharris BM, Kaye SB, Saverymuttu S et al (1980) VP-16 as single agent in advanced testicular tumors. Eur J Cancer 16:1193–1197
Schabel FM Jr, Trader MW, Laster WR Jr et al (1979) Cisplatin: combination chemotherapy and cross-resistance studies with tumors of mice. Cancer Treat Rep 63:1459–1473
Williams SD, Birch R, Irwin L, Greco A, Loehrer PJ, Einhorn LH (1987) Disseminated germ cell tumors: chemotherapy with cisplatin plus bleomycin plus either vinblastine or etoposide. NEJM 316:1435–1440
Birch R, Williams SD, Cone A, Einhorn LH et al (1986) Prognostic factors for favorable outcome in disseminated germ cell tumors. J Clin Oncol 4:400–407
Bosl GJ, Geller NL, Cirrincione C et al (1983) Multivariate analysis of prognostic variables in patients with metastatic testicular cancer. Cancer Res 43:3403–3407
Einhorn LH, Williams, SD, Loehrer PJ et al (1989) Evaluation of optimal duration of chemotherapy in favorable prognosis disseminated germ cell tumors: An SECSG Protocol. J Clin Oncol 7:387–391
Saxman S, Finch D, Gonin R, Einhorn LH (1998) Long-term follow-up of a phase III study of 3 versus 4 cycles of bleomycin, etoposide, and cisplatin in favorable prognosis germ cell tumors: The Indiana University experience. J Clin Oncol 16:702–706
Loehrer PJ, Einhorn LH, Elson P et al (1995) The importance of bleomycin in favorable prognosis disseminated germ cell tumors: An Eastern Cooperative Oncology Group Trial. J Clin Oncol 13:470–476
de Wit R, Stoter G, Kaye SB et al (1997) Importance of bleomycin in combination chemotherapy for good-prognosis testicular nonseminoma: A randomized study of the European Organization for Research and Treatment of Cancer Genitourinary Tract Cancer Cooperative Group. J Clin Oncol 15:1837–1843
Bosl GJ, Geller NL, Bajorin D, Leitner SP, Yagoda A et al (1988) A randomized trial of etoposide + cisplatin versus vinblastine + bleomycin + cisplatin + cyclophosphamide + dactinomycin in patients with good-prognosis germ cell tumors. J Clin Oncol 6:1231–1238
Bajorin DE, Geller NL, Weisen SE, Bosl GJ (1991) Two-drug therapy in patients with metastatic germ cell tumors. Cancer 67:28–32
Xiao H, Mazumdar M, Bajorin DE et al (1997) Long-term follow-up of patients with good-risk germ cell tumors treated with etoposide and cisplatin. Proc Amer Soc Clin Oncol 16:321
Horwich A, Sleijfer DT, Fossa SD, Kay SB, Oliver RTD et al (1997) Randomized trial of bleomycin, etoposide, and cisplatin compared with bleomycin, etoposide, and carboplatin in good-prognosis metastatic nonseminomatous germ cell cancer: A Multi-institutional Medical Research Council/European Organization for Research and Treatment of Cancer Trial. J Clin Oncol 15:1844–1852
Bajorin D, Sarosdy ME, Pfister DG et al (1993) Randomized trial of etoposide and cisplatin versus etoposide and carboplatin in patients with good-risk germ cell tumors. J Clin Oncol 11:598–608
International Germ Cell Collaborative Group (1997) International germ cell consensus classification: A prognostic factor-based staging system for metastatic germ cell cancers. J Clin Oncol 15:594–603
Nichols CR, Williams SD, Einhorn LH et al (1991) Randomized study of cisplatin dose intensity in advanced germ cell tumors: An SECSG and SWOG protocol. J Clin Oncol 9:1163–1172
Nichols CR, Loehrer PJ, Einhorn LH et al (1997) Phase III study of BEP versus VIP in advanced stage germ cell tumors: An intergroup trial. J Clin Oncol 16:1287–1293
Loehrer PJ, Gonin R, Nichols CR, Weathers T, Einhorn LH (1992) Vinblastine plus ifosfamide plus cisplatin as initial salvage therapy in recurrent germ cell tumor. J Clin Oncol 16:2500–2504
Broun ER, Nichols CR, Einhorn LH et al (1992) Long-term follow-up of salvage chemotherapy in relapsed and refractory germ cell tumors using high dose carboplatin and etoposide with autologous bone marrow support. Annals Intern Med 117:124–128
Bhatia S, Cometta K, Broun R, Nichols C, Abnour R, Einhorn LH (1998) High dose chemotherapy with peripheral stem cell or autologous transplant as initial salvage chemotherapy for testicular cancer. Proc Amer Soc Clin Oncol 17:321 (abstr)
Miller KD, Loehrer PJ, Gonin R, Einhorn LH (1997) Salvage chemotherapy with vinblastine, ifosfamide, and cisplatin in recurrent seminoma. J Clin Oncol 15:1427–1431
Saxman SB, Nichols CR, Einhorn LH et al (1996) The management of patients with clinical stage I nonseminomatous testicular tumors and persistently elevated serologic markers. J Urol 155:587–589
Davis BE, Herr HW, Fair WR, Bosl GJ (1994) The management of patients with nonseminomatous germ cell tumors of the testis with serologic disease only after orchiectomy. J Urol 152:111–114
Sheinfield J, Puc HS et al (1997) Surgery for a post-chemotherapy residual mass in seminoma. J Urol 157:860–862
Schultz SM, Einhorn, LH, Conces D et al (1989) Management of post-chemotherapy residual mass in patients with advanced seminoma: Indiana University Experience. J Clin Oncol 7:1497–1503
Horwich A, Paluchowska B, Norman A et al (1997) Residual mass following chemotherapy of seminoma. Ann Oncol 8:37–40
Toner GC, Panciek DM, Heelan RT et al (1990) Adjunctive surgery after chemotherapy for nonseminomatous germ cell tumors: recommendations for patient selection. J Clin Oncol 8:1683–1694
Debono DJ, Heilman DK, Einhorn LH, Donohue JP (1997) Decision analysis for avoiding post-chemotherapy surgery in patients with disseminated nonseminomatous germ cell tumors. J Clin Oncol 15:1455–1464
Baniel J, Foster RS, Gonin R, Messemer JE, Donohue JP, Einhorn LH (1995) Late relapse of testicular cancer. J Clin Oncol 13: 1170–1176
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer-Verlag France
About this paper
Cite this paper
Einhorn, L.H. (1999). Update in testicular cancer. In: Hortobagyi, G.N., Khayat, D. (eds) Progress in Anti-Cancer Chemotherapy. Progress in Anti-Cancer Chemotherapy, vol 3. Springer, Paris. https://doi.org/10.1007/978-2-8178-0918-2_9
Download citation
DOI: https://doi.org/10.1007/978-2-8178-0918-2_9
Publisher Name: Springer, Paris
Print ISBN: 978-2-287-59666-7
Online ISBN: 978-2-8178-0918-2
eBook Packages: Springer Book Archive