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Cancer Treatment An Update pp 219–224Cite as

Concomitant chemoradiotherapy in locally advanced head and neck cancers: a prospective study of 68 patients

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Abstract

For locally advanced, unresectable head and neck cancers, radiotherapy (RT) is the standard treatment but has poor results (25 % five year survival). Randomized trials showing improved survival in patients treated by concomitant chemoradiotherapy have been published for 5-FU, 5-FU-CDDP and Bleomycin [1, 2]. CDDP with 5-FU is a synergistic regimen against recurent and disseminated squamous cell carcinomas of the head and neck [3, 4]. To emphasize these results, we have attempted to increase the efficacy of RT with a concomitant and simultaneous Cisplatin (CDDP) and 5-Fluorouracil (5-FU) chemotherapy (protocol PURE).

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References

  1. Merlano M, Vitale V, Rooso R et al (1992) Treatment of advanced squamous cell carcinoma of the head and neck with alternating chemotherapy and radiotherapy. N Engl J Med 327, 16: 1115–1121

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  3. Kish JA, Weaver A, Jacobs J et al (1824) Cisplatine and 5-Fluorouracil in patients with recurrent and disseminated epidermoid cancer of the head and neck. Cancer 53: 1819–1824

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  4. Merlano M, Grimaldi A, Brunetti I et al (1987) Simultaneous Cisplatine and 5-Fluorouracile as second-line treatment of head and neck cancer. Cancer Treat Rep 71: 485–488

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Author information

Authors and Affiliations

  1. Service de Cancérologie-Radiothéraphie, Hôpital Saint-Louis, 1, avenue Claude-Velefaux, Paris, France

    S. Walter, C. Hennequin & C. Maylin

  2. Service de Chirurgie ORL et Maxillofaciale, Hôpital Saint-Louis, 1, avenue Claude-Velefaux, Paris, France

    M. D. Brette, P. Leblanc, P. Y. Cheriff-Cheikh & J. P. Monteil

  3. Service d’Oncologie Médicale, Hôpital Saint-Louis, 1, avenue Claude-Velefaux, Paris, France

    M. Espie & M. Marty

Authors
  1. S. Walter
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  2. C. Hennequin
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  3. M. D. Brette
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  4. P. Leblanc
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  5. P. Y. Cheriff-Cheikh
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  6. M. Espie
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  7. J. P. Monteil
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  8. M. Marty
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  9. C. Maylin
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Editor information

Editors and Affiliations

  1. Hôpital Saint-Louis, 1, avenue Vellefaux, 75475, Paris Cedex 10, France

    P. Banzet

  2. The Mount Sinai Medical Center, 1 G. Levy Place, New York, NY, 10029-6574, USA

    J. F. Holland

  3. Service d’Oncologie Médicale, Hôpital Pitié-Salpétrière Pavillon Jacquart, 47, boulevard de l’Hôpital, 75651, Paris Cedex 13, France

    D. Khayat

  4. Hôpital Pitié-Salpétrière Pavillon Jacquart, 47, boulevard de l’Hôpital, 75651, Paris Cedex 13, France

    M. Weil

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© 1994 Springer-Verlag France

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Walter, S. et al. (1994). Concomitant chemoradiotherapy in locally advanced head and neck cancers: a prospective study of 68 patients. In: Banzet, P., Holland, J.F., Khayat, D., Weil, M. (eds) Cancer Treatment An Update. Springer, Paris. https://doi.org/10.1007/978-2-8178-0765-2_42

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  • DOI: https://doi.org/10.1007/978-2-8178-0765-2_42

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0767-6

  • Online ISBN: 978-2-8178-0765-2

  • eBook Packages: Springer Book Archive

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