Abstract
A prospective randomized study of Cisplatin and 5-Fluorouracil (5-FU) proceeding loco regional treatment (LRT) as compared with LRT alone in squamous cell carcinoma (SCC) in head and neck cancer was conducted from September 1986 to October 1989. This study was designed to test the response rate of induction chemotherapy, the impact upon local regional control and survival.
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References
Carter SK (1977) The chemotherapy of head and neck cancer. Sem Oncol 4: 413–424
Decker DA, Drelichman A, Jacobs J, Hoschner J, Kinsie J, Loh JJK, Weaver A, Al-Sarraf M (1983) Adjuvant chemotherapy with CDDP and 120 hours infusion 5-FU in stage III and IV squamous cell carcinoma of the head and neck. Cancer J1: 1353–1355
Forestière A, Metch B, Schuller D, Ensley J et al (1992) Randomized comparison of Cisplatin plus Fluorouracil and Carboplatin plus Fluorouracil versus Methotrexate in advanced squamous cell carcinoma of the head and neck: a southwest oncology group study. J Clin Oncol 10: 1245–1251
Hass C, Anderson T, Byhard R, Cox J, Duncavage J, Grossman T, Hass J, Libnoch J, Malin T, Ritch P, Toohill R (1986) Randomized Neo-Adjuvant study of 5-FU and CDDP for patients with advanced resectable head and neck cancer. Proc Am Assoc Cancer Res 27: 185
Holoye PY, Byers RM, Gard DA, Goepfert H, Guillamondegui OM, Jesse RH (1978) Combination chemotherapy of head and neck. Cancer 42: 1661–1669
Hong WK, Bromer (1983) Current concepts, chemotherapy in head and neck cancer. N Engl J Med 308: 75–76
Kaplan E, Meier P (1958) Non parametric estimation from incomplete observation. J Am Stat Assoc 58: 475–481
Martin M, Mazeron JJ, Glaubiger D, Brun B, Langlois A, Feuillade F, Lelièvre G, Strunsky W, Vergnes L, Denarnaud J, Peynègre R, Pierquin B (1986) Neo-Adjuvant polychemotherapy of head and neck cancer. Preliminary results of a randomized study. Proc Am Soc Clin Oncol J 141
Martin M, Schuller DE, Wilson H, Hodgson S, Mattox D (1984) Pre-operative reductive chemotherapy for stage III or IV operable epidermoid carcinoma of the oral cavity and oropharynx, hypopharynx or larynx phase III, a southwest oncology group study. In: Vidockler HR (ed) Proceedings of international conference on head and neck cancer. Lancaster Press, Baltimore, p. 48
Martin M, Lelièvre G, Gehanno P, Depondt J, Guerrier B, Peytral C, Dubreuil P, Margotton A, Pellae Cosset B (1992) Induction Carboplatin and 5-FU treatment versus no chemotherapy before loco regional treatment for oro and pharyn-go laryngeal cancers: preliminary results of a randomized study. Proc 11 Assoc: 769
Taylor SG (1987) Integration of chemotherapy into the combined modality therapy of head and neck squamous cancer. Int J Radiat Oncol Biol Phys 13: 779–783
Vokes E, Schilsky R, Weichselbaum M, Kosloff M, Panje W (1990) Induction chemotherapy with Cisplatin, Fluorouracil, and high dose Leucovorin for locally advanced head and neck cancer: a clinical and pharmacologic analysis. J Clin Oncol 8: 241–247
Wittes R, Heller K, Randolph V, Shah J, Sairo R, Strong E (1979) CDDP based chemotherapy as initial treatment of advanced head and neck cancer. Cancer Treat Rep 63: 1533–1538
Wolf GT, Jacob C, Makuch RW, Vikram B (1984) CDDP and Bleomycine adjuvant chemotherapy in head and neck cancer: resultas of the head and neck contacts program. In: Vidockler HR, (ed.) Proceeding of the internationale conference on head and neck cancer. Lancaster Press, Baltimore, p. 43
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© 1994 Springer-Verlag France
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Martin, M. et al. (1994). A randomized study of CDDP and 5-FU as Neo-Adjuvant chemotherapy in head and neck cancer: an interim analysis. In: Banzet, P., Holland, J.F., Khayat, D., Weil, M. (eds) Cancer Treatment An Update. Springer, Paris. https://doi.org/10.1007/978-2-8178-0765-2_41
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DOI: https://doi.org/10.1007/978-2-8178-0765-2_41
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