Abstract
Recent advances in our understanding of cell cycle regulation suggest the possibility that successful chemotherapy may often depend on the presence of cell cycle control defects in the responding tumor cells. These control defects may arise, directly or indirectly, from functional abnormalities in proto-oncogenes or tumor suppressor genes that are common in clinical tumors. This paper will outline some aspects of cell cycle regulation — as currently understood in this rapidly advancing field — that may affect drug sensitivity and that might become the basis for a new approach to cancer chemotherapy.
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© 1994 Springer-Verlag France
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Kohn, K.W., O’Connor, P.M. (1994). Cell cycle regulation and the chemosensitivity of cancer cells. In: Banzet, P., Holland, J.F., Khayat, D., Weil, M. (eds) Cancer Treatment An Update. Springer, Paris. https://doi.org/10.1007/978-2-8178-0765-2_16
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DOI: https://doi.org/10.1007/978-2-8178-0765-2_16
Publisher Name: Springer, Paris
Print ISBN: 978-2-8178-0767-6
Online ISBN: 978-2-8178-0765-2
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