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Wnt/Frizzled Signaling in the Vasculature

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Molecular Mechanisms of Angiogenesis

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Abstract

Signaling, by the Wnt family of secreted glycolipoproteins, is one of the fundamental mechanisms that direct cell proliferation, polarity, and fate determination during embryonic development and tissue homeostasis. Recent advances in vascular biology highlight important roles for multiple components of the Wnt-signaling pathway in regulating differential behavior and/or cell functions during vascular development. The canonical Wnt pathway, which has been well characterized, functions by regulating the amount of the transcriptional coactivator ß-catenin, which in turn controls key developmental gene expression programs. Wnt also activates a number of noncanonical signaling pathways that are independent of ß-catenin. In this review, we report several novel findings regarding the molecular role of Wnt signaling during both vascular development and pathological angiogenesis.

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Authors and Affiliations

  1. Inserm, Adaptation cardiovasculaire à l’ischémie, U1034, Pessac, F-33600, France

    Thierry Couffinhal, Pascale Dufourcq & Cécile Duplàa

  2. Univ. Bordeaux, Adaptation cardiovasculaire à l’ischémie, U1034, Pessac, F-33600, France

    Thierry Couffinhal & Pascale Dufourcq

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  1. Thierry Couffinhal
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  2. Pascale Dufourcq
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  3. Cécile Duplàa
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Correspondence to Cécile Duplàa .

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  1. UMR 1036, Biologie du Cancer et de l’Infection, Institut de Recherches en Technologies et Sciences pour le Vivant, Université Grenoble-Alpes, Grenoble, France

    Jean-Jacques Feige

  2. Institute for Research on Cancer and aging of Nice (IRCAN), University of Nice Sophia Antipolis, Nice, France

    Gilles Pagès

  3. CNRS UMR8161, Institut Pasteur de Lille, Institut de Biologie de Lille, Lille, France

    Fabrice Soncin

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Couffinhal, T., Dufourcq, P., Duplàa, C. (2014). Wnt/Frizzled Signaling in the Vasculature. In: Feige, JJ., Pagès, G., Soncin, F. (eds) Molecular Mechanisms of Angiogenesis. Springer, Paris. https://doi.org/10.1007/978-2-8178-0466-8_4

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