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Tumor High Endothelial Venules and Lymphocyte Trafficking

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Molecular Mechanisms of Angiogenesis

Abstract

Blood vessels and tumor angiogenesis are generally associated with tumor growth and poor clinical outcome of cancer patients. However, it has been recently discovered that some blood vessels present within the tumor microenvironment can be associated with a good prognosis by contributing to tumor suppression rather than tumor growth. These specialized blood vessels, designated high endothelial venules (HEVs), are normally found in lymph nodes where they mediate high levels of lymphocyte extravasation from the blood. A high density of tumor HEVs in human breast carcinomas and melanomas was associated with high levels of cytotoxic lymphocyte infiltration, indicating that HEVs may participate in the eradication of tumors by facilitating the access of “killer” lymphocytes into tumor tissues. A better understanding of the mechanisms regulating tumor HEVs could thus have an important impact for cancer therapy. Dendritic cells and the lymphotoxin pathway have been shown to be critical for maintenance of HEV differentiation in lymph nodes and may also regulate tumor HEVs. In this chapter, we will first describe the unique properties of lymph node HEVs and their role in lymphocyte trafficking. We will then review the phenotypic characteristics of tumor HEVs and their association with lymphocyte infiltration and favorable clinical outcome of cancer patients. Finally, we will discuss the promising potential of tumor HEVs for cancer therapy.

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Authors and Affiliations

  1. CNRS, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France

    Krystle M. Veerman, Fanny Lafouresse & Jean-Philippe Girard

  2. Université de Toulouse, Université Paul Sabatier, IPBS, Toulouse, France

    Krystle M. Veerman, Fanny Lafouresse & Jean-Philippe Girard

Authors
  1. Krystle M. Veerman
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  2. Fanny Lafouresse
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  3. Jean-Philippe Girard
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Corresponding author

Correspondence to Jean-Philippe Girard .

Editor information

Editors and Affiliations

  1. UMR 1036, Biologie du Cancer et de l’Infection, Institut de Recherches en Technologies et Sciences pour le Vivant, Université Grenoble-Alpes, Grenoble, France

    Jean-Jacques Feige

  2. Institute for Research on Cancer and aging of Nice (IRCAN), University of Nice Sophia Antipolis, Nice, France

    Gilles Pagès

  3. CNRS UMR8161, Institut Pasteur de Lille, Institut de Biologie de Lille, Lille, France

    Fabrice Soncin

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Veerman, K.M., Lafouresse, F., Girard, JP. (2014). Tumor High Endothelial Venules and Lymphocyte Trafficking. In: Feige, JJ., Pagès, G., Soncin, F. (eds) Molecular Mechanisms of Angiogenesis. Springer, Paris. https://doi.org/10.1007/978-2-8178-0466-8_16

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