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Emergence of Endothelial Cells During Vascular Development

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Molecular Mechanisms of Angiogenesis

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Abstract

Arteries, capillaries, and veins form the vascular system that supplies oxygen and nutrients to all tissues and removes waste products. In the embryo the vascular system is the first system to emerge during vasculogenesis, and the factors that initiate the patterning of the endothelial network are, for the most part, involved in the adult angiogenesis. Dysfunctions of the vascular system cause numerous pathologies, including artherosclerosis, cancer, and ocular diseases. Understanding how endothelial cells differentiate and deciphering the cellular, molecular, and physical clues that drive blood vessel formation in the embryo may therefore provide means to develop therapies against vascular diseases in the adult. In this review, we present recent findings that identify new candidates controlling vascular system development.

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Authors and Affiliations

  1. Department of Cardiology, Yale University School of Medicine, 300 George Street, New Haven, CT, 06510-3221, USA

    Anne Eichmann

  2. Collège de France, Center for Interdisciplinary Research in Biology (CIRB), Paris, 75005, France

    Anne Eichmann & Luc Pardanaud

  3. INSERM U1050, Paris, 75005, France

    Anne Eichmann & Luc Pardanaud

  4. CNRS UMR 7241, Paris, 75005, France

    Anne Eichmann & Luc Pardanaud

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  1. Anne Eichmann
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  2. Luc Pardanaud
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Correspondence to Anne Eichmann .

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Editors and Affiliations

  1. UMR 1036, Biologie du Cancer et de l’Infection, Institut de Recherches en Technologies et Sciences pour le Vivant, Université Grenoble-Alpes, Grenoble, France

    Jean-Jacques Feige

  2. Institute for Research on Cancer and aging of Nice (IRCAN), University of Nice Sophia Antipolis, Nice, France

    Gilles Pagès

  3. CNRS UMR8161, Institut Pasteur de Lille, Institut de Biologie de Lille, Lille, France

    Fabrice Soncin

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Eichmann, A., Pardanaud, L. (2014). Emergence of Endothelial Cells During Vascular Development. In: Feige, JJ., Pagès, G., Soncin, F. (eds) Molecular Mechanisms of Angiogenesis. Springer, Paris. https://doi.org/10.1007/978-2-8178-0466-8_1

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