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Les biomarqueurs moléculaires en oncologie pp 115–127Cite as

Susceptibilité individuelle et toxicité de la radiothérapie

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Résumé

En 1901, six ans après la découverte des rayons X par Wilhelm Röntgen, Henri Becquerel et Pierre Curie publient une note officielle à l’Académie des sciences sur l’action physiologique des rayons du radium [1]. En reproduisant l’expérience de Friedrich Giesel, Pierre Curie décrit les diverses rougeurs, brûlures et plaies qu’a provoquées l’exposition, durant une dizaine d’heures, de chlorure de baryum radifère sur son avant-bras. Les symptômes décrits sont les mêmes que ceux de Marie Curie et d’Henri Becquerel, lorsque ces derniers transportent dans une poche de leur gilet un petit tube métallique scellé avec quelques centigrammes de cette même matière active. Ces diverses observations conduisent rapidement à la conclusion de l’existence d’un effet biologique des rayonnements ionisants sur les tissus.

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Authors and Affiliations

  1. Pôle de radiothérapie oncologique, Institut du cancer de Montpellier, Inserm U896, Institut de recherche en cancérologie de Montpellier, France

    J. Lacombe, O. Riou, J. Solassol, A. Mangé, M. Ozsahin & D. Azria

Authors
  1. J. Lacombe
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  2. O. Riou
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  3. J. Solassol
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  4. A. Mangé
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  5. M. Ozsahin
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  6. D. Azria
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Corresponding author

Correspondence to D. Azria .

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Editors and Affiliations

  1. Unité de biologie des tumeurs, Institut de Cancérologie de Lorraine & Université de Lorraine, 6, avenue de Bourgogne, Vandœuvre-lès-Nancy Cedex, 54519, France

    Jean-Louis Merlin

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Lacombe, J., Riou, O., Solassol, J., Mangé, A., Ozsahin, M., Azria, D. (2014). Susceptibilité individuelle et toxicité de la radiothérapie. In: Merlin, JL. (eds) Les biomarqueurs moléculaires en oncologie. Springer, Paris. https://doi.org/10.1007/978-2-8178-0445-3_9

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  • DOI: https://doi.org/10.1007/978-2-8178-0445-3_9

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0444-6

  • Online ISBN: 978-2-8178-0445-3

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