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Diagnostic de la maladie d’Alzheimer

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Traité sur la maladie d’Alzheimer

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Résumé

Le diagnostic des syndromes démentiels et de la maladie d’Alzheimer en particulier subit actuellement une mutation conceptuelle importante liée à l’avènement puis à la mise en pratique progressive de nouvelles techniques de diagnostic paraclinique. Ces techniques permettent d’identifier des « biomarqueurs » d’affections neurodégénératives lentement progressives dont le diagnostic était basé antérieurement sur des arguments essentiellement cliniques et neuropsychologiques; la paraclinique n’était alors utilisée que pour exclure d’autres causes, d’ailleurs plus rares, de démence. Ce changement de paradigme s’accompagne d’un effort de systématisation sous la forme de listes de critères orientant le diagnostic en termes de probabilité. Après une première version remontant à 1984 [1], ces critères viennent d’être révisés par l’influent groupe d’experts du National Institute on Aging (NIA)- Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease (ci-après NIA-AA workgroups) (cf. [7], p. 253 et seq.).

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Références

  1. McKhann G, Drachman D, Folstein M, et al. (1984) Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDAWork Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease. Neurology 34: 939–44

    Article  CAS  PubMed  Google Scholar 

  2. Braak H, Alafuzoff I, Arzberger T, et al. (2006) Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 112: 389–404

    Article  PubMed Central  PubMed  Google Scholar 

  3. Dubois B, Feldman HH, Jacova C, et al. (2007) Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 6: 734–46

    Article  PubMed  Google Scholar 

  4. Morris JC (1993) The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 43: 2412–4

    Article  CAS  PubMed  Google Scholar 

  5. Diagnostic and Statistical Manual of Mental Disorders (DSM) version DSM-IV-TR (2000) The American Psychiatric Association

    Google Scholar 

  6. McKhann GM, Knopman DS, Chertkow H, et al. (2011) The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 7: 263–9

    Article  PubMed Central  PubMed  Google Scholar 

  7. Jack CR Jr, Albert MS, Knopman DS, et al. (2011) Introduction to the recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7: 257–62

    Article  PubMed Central  PubMed  Google Scholar 

  8. Jellinger KA (2009) Recent advances in our understanding of neurodegeneration. J Neural Transm 116: 1111–62

    Article  CAS  PubMed  Google Scholar 

  9. Jellinger K, Attems J (2010) Prevalence of dementia disorders in the oldest-old: an autopsy study. Acta Neuropathol 119: 421–33

    Article  PubMed  Google Scholar 

  10. Albert MS, DeKosky ST, Dickson D, et al. (2011) The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7: 270–9

    Article  PubMed Central  PubMed  Google Scholar 

  11. Barberger-Gateau P, Commenges D, Gagnon M, et al. (1992) Instrumental activities of daily living as a screening tool for cognitive impairment and dementia in elderly community dwellers. J Am Geriatr Soc 40: 1129–34

    CAS  PubMed  Google Scholar 

  12. Calabria M, Manenti R, Rosini S, et al. (2011) Objective and subjective memory impairment in elderly adults: a revised version of the Everyday Memory Questionnaire. Aging Clin Exp Res 23: 67–73

    Article  PubMed  Google Scholar 

  13. Zarit SH, Reever KE, Bach-Peterson J (1980) Relatives of the impaired elderly: correlates of feelings of burden. Gerontologist 20: 649–55

    Article  CAS  PubMed  Google Scholar 

  14. Hugonot-Diener L, Clément J-P (2008) Échelle de dépression gériatrique. In: Hugonot-Diener L, Barbeau E, Michel B-F, Thomas-Anterion C, Robert P (eds) 2008) GREMOIRE: tests et échelles de la maladie d’Alzheimer et des syndromes apparentés. Solal, Marseille, p. 275–7

    Google Scholar 

  15. Panza F, Frisardi V, Capurso C, et al. (2010) Late-life depression, mild cognitive impairment, and dementia: possible continuum? Am J Geriatr Psychiatry 18:98–116

    Article  PubMed  Google Scholar 

  16. Byers AL, Yaffe K (2011) Depression and risk of developing dementia. Nat Rev Neurol 7: 323–31

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Hugonot-Diener L, Barbeau E, Michel B-F, et al. (eds) (2008) GREMOIRE: tests et échelles de la maladie d’Alzheimer et des syndromes apparentés. Solal, Marseille

    Google Scholar 

  18. Saint-Aubert L, Payoux P, Hannequin D, et al. (2012) MR, 18F-FDG and 18F-AV45 PET correlate with AD PSEN1 original phenotype. Alzheimer’s Disease and Associated Disorders (in press)

    Google Scholar 

  19. Thomas-Anterion C, Barbeau E (2011) Neuropsychologie en pratique(s). Solal, Marseille

    Google Scholar 

  20. Godefroy O, le GREFEX (2008) Fonctions exécutives et pathologies neurologiques et psychiatriques. Solal, Marseille

    Google Scholar 

  21. Hulstaert F, Blennow K, Ivanoiu A, et al. (1999) Improved discrimination of AD patients using beta-amyloid(l-42) and tau levels in CSF. Neurology 52: 1555–62

    Article  CAS  PubMed  Google Scholar 

  22. Mattsson N, Zetterberg H, Hansson O, et al. (2009) CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment. JAMA 302: 385–93

    Article  CAS  PubMed  Google Scholar 

  23. Scheltens P, Fox N, Barkhof F, De Carli C (2002) Structural magnetic resonance imaging in the practical assessment of dementia: beyond exclusion. Lancet Neurol 1: 13–21

    Article  PubMed  Google Scholar 

  24. Villain N, Fouquet M, Baron JC, et al. (2010) Sequential relationships between grey matter and white matter atrophy and brain metabolic abnormalities in early Alzheimer’s disease. Brain 133: 3301–14

    Article  PubMed Central  PubMed  Google Scholar 

  25. Jack CR Jr, Lowe VJ, Senjem ML, et al. (2008) 11C PiB and structural MRI provide complementary information in imaging of Alzheimer’s disease and amnestic mild cognitive impairment. Brain 131: 665–80

    Article  PubMed Central  PubMed  Google Scholar 

  26. Tosun D, Schuff N, Mathis CA, et al., Alzheimer’s Disease NeuroImaging Initiative (2011) Spatial patterns of brain amyloid-beta burden and atrophy rate associations in mild cognitive impairment. Brain 134: 1077–88

    Google Scholar 

  27. Braak H, Alafuzoff I, Arzberger T, et al. (2006) Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 112: 389–404

    Article  PubMed Central  PubMed  Google Scholar 

  28. Hyman BT (1997) The Neuropathological Diagnosis of Alzheimer’s Disease: Clinical-Pathological Studies. Neurobiology of Aging 18 Suppl: S27–S32

    Article  CAS  PubMed  Google Scholar 

  29. Montine TJ, Phelps CH, Beach TG, et al. (2012) National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach. Acta Neuropathol 123: 1–11

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  30. Ballard C, Gauthier S, Corbett A, et al. (2011) Alzheimer’s disease. Lancet 377: 1019–31

    Article  PubMed  Google Scholar 

  31. Murray ME, Graff-Radford NR, Ross OA, et al. (2011) Neuropathologically defined subtypes of Alzheimer’s disease with distinct clinical characteristics: a retrospective study. Lancet Neurol 10: 785–96

    Article  PubMed Central  PubMed  Google Scholar 

  32. Hachinski V, Iadecola C, Petersen RC, et al. (2006) National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke 37: 2220–41

    Article  PubMed  Google Scholar 

  33. McKeith IG, Dickson DW, Lowe J, et al., Consortium on DLB (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65: 1863–72

    Google Scholar 

  34. Johnson JK, Head E, Kim R, et al. (1999) Clinical and pathological evidence for a frontal variant of Alzheimer disease. Arch Neurol 56: 1233–9

    Article  CAS  PubMed  Google Scholar 

  35. Neary D, Snowden JS, Gustafson L, et al. (1998) Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 51: 1546–54

    Article  CAS  PubMed  Google Scholar 

  36. Cairns NJ, Bigio EH, Mackenzie IR, et al., Consortium for Frontotemporal Lobar Degeneration. (2007) Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol 114: 5–22

    Google Scholar 

  37. Rossor MN, Fox NC, Mummery CJ, et al. (2010) The diagnosis of young-onset dementia. Lancet Neurol 9: 793–806

    Article  PubMed Central  PubMed  Google Scholar 

  38. Ransmayr G, Seppi K, Donnemiller E, et al. (2001) Striatal dopamine transporter function in dementia with Lewy bodies and Parkinson’s disease. Eur J Nucl Med 28: 1523–8

    Article  CAS  PubMed  Google Scholar 

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  1. Département des neurosciences cliniques, Centre Leenaards de la Mémoire - CHUV, Rue du Bugnon 46, CH-1011, Lausanne, France

    J.-F. Démonet

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Démonet, JF. (2013). Diagnostic de la maladie d’Alzheimer. In: Traité sur la maladie d’Alzheimer. Springer, Paris. https://doi.org/10.1007/978-2-8178-0443-9_1

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  • DOI: https://doi.org/10.1007/978-2-8178-0443-9_1

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0442-2

  • Online ISBN: 978-2-8178-0443-9

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