Advertisement

La corticothérapie prénatale en 2012

  • G. Cambonie
  • J. Baleine
  • S. Durand
  • A. Rideau Batista-Novais

Résumé

Les bénéfices pour le nouveau-né prématuré d’une cure prénatale unique de corticoïdes sont établis depuis presque vingt ans. Cependant, ils sont limités à sept jours, posant question sur les modalités pour préserver l’acquis précieux quand persiste un risque de prématurité. Les cures hebdomadaires ou bimensuelles systématiques sont abandonnées, car le bénéfice néonatal immédiat est occulté par un défaut de croissance cérébrale du foetus, soulevant des craintes sur son développement neurologique futur. La cure unique de sauvetage se présente comme une alternative intéressante, avec un effet pulmonaire comparable pour un retentissement plus modéré sur la biométrie fœtale. Cette stratégie cependant ne fait pas encore l’objet de recommandation, faute de consensus sur sa réalisation pratique et de données complémentaires sur le suivi à long terme des enfants traités. Enfin, aucune donnée sérieuse ne cautionne la corticothérapie prénatale au-delà de 34 SA ou dans le contexte d’une césarienne élective à terme.

Mots clés

corticothérapie prénatale nouveau-né prématurité syndrome de détresse respiratoire 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Références

  1. 1.
    Liggins GC (1969) Premature delivery of foetal lambs infused with glucocorticoids. J Endocrinol 45: 515–523PubMedCrossRefGoogle Scholar
  2. 2.
    Liggins GC, Howie RN (1972) A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics 50: 515–525PubMedGoogle Scholar
  3. 3.
    Uno H, Lohmiller L, Thieme C, et al. (1990) Brain damage induced by prenatal exposure to dexamethazone in fetal rhesus macaques. I. Hippocampus. Brain Res Dev Brain Res 53: 157–167PubMedCrossRefGoogle Scholar
  4. 4.
    Ten Centre Study Group (1987) Ten centre trial of artificial surfactant (artificial lung expanding compound) in very premature babies. Br Med J 294: 991–996CrossRefGoogle Scholar
  5. 5.
    Corbet A, Bucciarelli R, Goldman S, et al. (1991) US Exosurf Pediatric Group 1. Decreased mortality rate among small premature infants treated at birth with a single dose of synthetic surfactant: a multicenter controlled trial. J Pediatr 118: 277–284PubMedCrossRefGoogle Scholar
  6. 6.
    Crowley PA (1995) Antenatal corticosteroid therapy: A meta-analysis of the randomized trials, 1972 to 1994. Am J Obstet Gynecol 173: 322–335PubMedCrossRefGoogle Scholar
  7. 7.
    Roberts D, Dalziel SR (2006) Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 3: CD004454PubMedGoogle Scholar
  8. 8.
    Baud O, Sola A (2007) Corticosteroids in perinatal medicine: How to improve outcomes without affecting the developing brain? Semin Fetal Neonatal Med 12: 273–279PubMedCrossRefGoogle Scholar
  9. 9.
    Arad I, Durkin MS, Hinton VJ, et al. (2002) Long-term cognitive benefits of antenatal corticosteroids for prematurely born children with cranial ultrasound abnormalities. Am J Obstet Gynecol 186: 818–825PubMedCrossRefGoogle Scholar
  10. 10.
    Dalziel SR, Walker NK, Parag V, et al. (2005) Cardiovascular risk factors after antenatal exposure to betamethasone: 30-year follow-up of a randomised controlled trial. Lancet 365: 1856–1862PubMedCrossRefGoogle Scholar
  11. 11.
    Schwab M, Roedel M, Anwar MA, et al. (2000) Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J Physiol 528: 619–632PubMedCrossRefGoogle Scholar
  12. 12.
    Cambonie G, Mesnage R, Milési C, et al. (2008) Betamethasone impairs cerebral blood flow velocities in very premature infants with severe chronic lung disease. J Pediatr 152: 270–275PubMedCrossRefGoogle Scholar
  13. 13.
    National Institutes of Health (1994) Effect of corticosteroids for fetal maturation on perinatal outcomes. NIH Consensus Statement. JAMA 273: 413–418Google Scholar
  14. 14.
    Baud O, Laudenbach V, Evrard P, et al. (2001) Neurotoxic effects of fluorinated glucocorticoids preparations on the developing mouse brain: role of preservatives. Pediatr Res 50: e706–e711CrossRefGoogle Scholar
  15. 15.
    Baud O, Foix-L’Helias L, Kaminski M, et al. (1999) Antenatal glucocorticoid treatment and cystic periventricular leukomalacia in very premature infants. N Engl J Med 341: 1190e6CrossRefGoogle Scholar
  16. 16.
    Jobe AH, Soll RF (2004) Choice and dose of corticosteroid for antenatal treatments. Am J Obstet Gynecol 190: e878–e881CrossRefGoogle Scholar
  17. 17.
    Lee BH, Stoll BJ, McDonald SA, et al. (2006) Adverse neonatal outcomes associated with antenatal dexamethasone versus antenatal betamethasone. Pediatrics 117: 1503–1510PubMedCrossRefGoogle Scholar
  18. 18.
    Lee BH, Stoll BJ, McDonald SA (2008) Neurodevelopmental outcomes of extremely low birth weight infants exposed prenatally to dexamethasone versus betamethasone. Pediatrics 121: 289–296PubMedCrossRefGoogle Scholar
  19. 19.
    Brownfoot FC, Crowther CA, Middleton P (2008) Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 4: CD006764PubMedGoogle Scholar
  20. 20.
    Newnham JP, Jobe AH (2009) Should we be prescribing repeated courses of antenatal corticosteroids? Semin Fetal Neonatal Med 14: 157–163PubMedCrossRefGoogle Scholar
  21. 21.
    Aghajafari F, Murphy K, Matthews S, et al. (2002) Repeated doses of antenatal corticosteroids in animals: a systematic review. Am J Obstet Gynecol 186: 843–849PubMedCrossRefGoogle Scholar
  22. 22.
    French NP, Hagan R, Evans SF, et al. (1999) Repeated antenatal corticosteroids: size at birth and subsequent development. Am J Obstet Gynecol 180: 114–121PubMedCrossRefGoogle Scholar
  23. 23.
    French NP, Hagan R, Evans SF, et al. (2004) Repeated antenatal corticosteroids: effects on cerebral palsy and childhood behaviour. Am J Obstet Gynecol 190: 588–595PubMedCrossRefGoogle Scholar
  24. 24.
    Mildenhall LF, Battin MR, Morton SMB, et al. (2006) Exposure to repeat doses of antenatal glucocorticoids is associated with altered cardiovascular status after birth. Arch Dis Child Fetal Neonatal Ed 91: F56–F60PubMedCrossRefGoogle Scholar
  25. 25.
    Spinillo A, Viazzo F, Colleoni R, et al. (2004) Two-year infant neurodevelopmental outcome after single or multiple antenatal courses of corticosteroids to prevent complications of prematurity. Am J Obstet Gynecol 191: 217–224PubMedCrossRefGoogle Scholar
  26. 26.
    Murphy K, Hannah M, Willan A, et al. (2008) Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial. Lancet 372: 2143–2151PubMedCrossRefGoogle Scholar
  27. 27.
    Crowther CA, Haslam RR, Hiller JE, et al. (2006) Neonatal respiratory distress syndrome after repeat exposure to antenatal corticosteroids: a randomised controlled trial. Lancet 367: 1913–1919PubMedCrossRefGoogle Scholar
  28. 28.
    Guinn DA, Atkinson MW, Sullivan L, et al. (2001) Single vs weekly courses of antenatal corticosteroids for women at risk of preterm delivery. JAMA 286: 1581–1587PubMedCrossRefGoogle Scholar
  29. 29.
    Wapner RJ, Sorokin Y, Thom EA, et al. (2006) Single versus weekly courses of antenatal corticosteroids: evaluation of safety and efficacy. Am J Obstet Gynecol 195: 633–642PubMedCrossRefGoogle Scholar
  30. 30.
    Garite T, Kurtzman J, Maurel K, et al. (2009) Impact of a’ rescue course’ of antenatal corticosteroids: a multicenter randomized placebo-controlled trial. Am J Obstet Gynecol 200: 248.e1–248.e9CrossRefGoogle Scholar
  31. 31.
    Peltoniemi OM, Kari MA, Tammela O, et al. (2007) Randomized trial of a single repeat dose of prenatal betamethasone treatment in imminent preterm birth. Pediatrics 119: 290–298PubMedCrossRefGoogle Scholar
  32. 32.
    Aghajafari F, Murphy K, Ohlsson A, et al. (2002) Multiple versus single courses of antenatal corticosteroids for preterm birth: a pilot study. J Obstet Gynaecol Can 24: 321–329PubMedGoogle Scholar
  33. 33.
    McEvoy C, Bowling S, Williamson R, et al. (2002) The effect of a single remote course versus weekly courses of antenatal corticosteroids on functional residual capacity in preterm infants: a randomized trial. Pediatrics 110: 280–284PubMedCrossRefGoogle Scholar
  34. 34.
    Mazumder P, Dutta S, Kaur J, et al. (2008) Single versus multiple courses of antenatal betamethasone and neonatal outcome: a randomized controlled trial. Indian Pediatrics 45: 650–652Google Scholar
  35. 35.
    McEvoy C, Schilling D, Peters D, et al. (2010) Respiratory compliance in preterm infants after a single rescue course of antenatal steroids: a randomized controlled trial. Am J Obstet Gynecol 202: 544.e1–544.e9CrossRefGoogle Scholar
  36. 36.
    Crowther CA, McKinlay CJ, Middleton P, et al. (2011) Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes. Cochrane Database Syst Rev 6: CD003935PubMedGoogle Scholar
  37. 37.
    Peltoniemi OM, Kari MA, Hallman M (2011) Repeated antenatal corticosteroid treatment: a systematic review and meta-analysis. Acta Obstet Gynecol Scand 90: 719–727PubMedCrossRefGoogle Scholar
  38. 38.
    Crowther CA, Doyle LW, Haslam RR, et al. (2007) Outcomes at 2 years of age after repeat doses of antenatal corticosteroids. N Engl J Med 357: 1179–1189PubMedCrossRefGoogle Scholar
  39. 39.
    Pesonen AK, Raikkonen K, Lano A, et al. (2009) Antenatal betamethasone and fetal growth in prematurely born children: implications for temperament traits at the age of 2 years. Pediatrics 123: e31–e37PubMedCrossRefGoogle Scholar
  40. 40.
    Wapner RJ, Sorokin Y, Mele L, et al. (2007) Long-term outcomes after repeat doses of antenatal corticosteroids. N Engl J Med 357: 1190–1198PubMedCrossRefGoogle Scholar
  41. 41.
    Tyson JE, Parikh NA, Langer J, et al. (2008) Intensive Care for Extreme Prematurity — Moving Beyond Gestational Age. N Engl J Med 358: 1672–1681PubMedCrossRefGoogle Scholar
  42. 42.
    Costeloe K, Hennessy E, Gibson AT, et al. (2000) The EPICure study: outcomes to discharge from hospital for infants born at the threshold of viability. Pediatrics 106: 659–671PubMedCrossRefGoogle Scholar
  43. 43.
    Amorim MM, Santos LC, Faundes A (1999) Corticosteroid therapy for prevention of respiratory distress syndrome in severe preeclampsia. Am J Obstet Gynecol 180: 1283–1288PubMedCrossRefGoogle Scholar
  44. 44.
    Porto AMF, Coutinho IC, Correia JB, et al. (2011) Effectiveness of antenatal corticosteroids in reducing respiratory disorders in late preterm infants: randomised clinical trial. BMJ 342: d1696PubMedCrossRefGoogle Scholar
  45. 45.
    Zanardo V, Simbi AK, Franzoi M, et al. (2004) Neonatal respiratory morbidity risk and mode of delivery at term: influence of timing of elective caesarean delivery. Acta Paediatrica 93: 643–647PubMedCrossRefGoogle Scholar
  46. 46.
    Stutchfield P, Whitaker R, Russell I (2005) Antenatal betamethasone and incidence of neonatal respiratory distress after elective caesarean section: pragmatic randomised trial. BMJ 331: 662PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag France 2013

Authors and Affiliations

  • G. Cambonie
    • 1
  • J. Baleine
    • 1
  • S. Durand
    • 1
  • A. Rideau Batista-Novais
    • 1
  1. 1.CHRUHôpital Arnaud de VilleneuveMontpellier Cedex 5France

Personalised recommendations