Abstract
White adipose tissue is composed of mature adipocytes, precursors (preadipocytes), endothelial cells, macrophages, and other immune cells. The phenotype, amount, and biology of each adipose tissue component are profoundly altered in human obesity. Low-grade inflammation both at the local and systemic levels characterizes obesity and appears to have a key role in mediating the consequence of increased adipose tissue mass on metabolic and vascular co-morbidities. Moreover, a new concept of accumulation of extracellular matrix (ECM) components in adipose tissue has been recently proposed. Integrity of the ECM is essential for the proper development of AT in a physiological context. In pathologic conditions, more knowledge is nevertheless necessary to understand the contribution of ECM modifications and the consequence of fibrous depots. Observations in morbidly obese subjects suggest that the amount of fibrosis might hamper fat mass loss induced by surgery.
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Tordjman, J. (2013). Histology of Adipose Tissue. In: Bastard, JP., Fève, B. (eds) Physiology and Physiopathology of Adipose Tissue. Springer, Paris. https://doi.org/10.1007/978-2-8178-0343-2_6
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DOI: https://doi.org/10.1007/978-2-8178-0343-2_6
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