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Prospects for Using Adipose Tissue in Regenerative Medicine

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Physiology and Physiopathology of Adipose Tissue

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Abstract

For long time, the presence of adipocyte precursors was demonstrated in the stroma vascular fraction of adipose tissue. These cells are now named adipose-derived stroma/stem cells (ASC) as it was demonstrated that they are multipotent, display a strong pro-angiogenic potential, and share numerous features with the bone marrow-derived mesenchymal stem cells. Furthermore, the frequency of ASC into the fat and the easiness to obtain large amount of this tissue opens numerous and promising perspectives in regenerative medicine.

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References

  • Ailhaud G, Grimaldi P, Negrel R (1992) Cellular and molecular aspects of adipose tissue development. Annu Rev Nutr 12:207–233

    Article  PubMed  CAS  Google Scholar 

  • Bel A, Planat-Bernard V, Saito A et al (2010) Composite cell sheets: a further step toward safe and effective myocardial regeneration by cardiac progenitors derived from embryonic stem cells. Circulation 122:S118–S123

    Article  PubMed  Google Scholar 

  • Charbord P (2010) Bone marrow mesenchymal stem cells: historical overview and concepts. Hum Gene Ther 21:1045–1056

    Article  PubMed  CAS  Google Scholar 

  • Charbord P, Casteilla L (2011) Human mesenchymal stem cell biology. Med Sci (Paris) 27:261–267

    Article  Google Scholar 

  • Constantin G, Marconi S, Rossi B et al (2009) Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis. Stem Cells 27:2624–2635

    Article  PubMed  CAS  Google Scholar 

  • Corre J, Barreau C, Cousin B et al (2006) Human subcutaneous adipose cells support hematopoietic differentiation in vitro. J Cell Physiol 206:282–288

    Article  Google Scholar 

  • Cousin B, Andre M, Arnaud E et al (2003) Reconstitution of lethally irradiated mice by cells isolated from adipose tissue. Biochem Biophys Res Commun 301:1016–1022

    Article  PubMed  CAS  Google Scholar 

  • Cousin B, Ravet E, Poglio S et al (2009) Adult stromal cells derived from human adipose tissue provoke pancreatic cancer cell death both in vitro and in vivo. PLoS One 4:6278

    Article  Google Scholar 

  • Crisan M, Yap S, Casteilla L et al (2008) A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3:301–313

    Article  PubMed  CAS  Google Scholar 

  • De Toni F, Poglio S, Youcef AB et al (2011) Human adipose-derived stromal cells efficiently support hematopoiesis in vitro and in vivo: a key step for therapeutic studies. Stem Cells Dev 20(12):2127–2138

    Article  PubMed  Google Scholar 

  • Ebrahimian TG, Pouzoulet F, Squiban C et al (2009) Cell therapy based on adipose tissue-derived stromal cells promotes physiological and pathological wound healing. Arterioscler Thromb Vasc Biol 29:503–510

    Article  PubMed  CAS  Google Scholar 

  • Garcia-Olmo D, Herreros D, Pascual I et al (2009) Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase ii clinical trial. Dis Colon Rectum 52:79–86

    Article  PubMed  Google Scholar 

  • Gimble JM, Katz AJ, Bunnell BA (2007) Adipose-derived stem cells for regenerative medicine. Circ Res 100:1249–1260

    Article  PubMed  CAS  Google Scholar 

  • Gonzalez MA, Gonzalez-Rey E, Rico L et al (2009) Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells. Arthr Rheum 60:1006–1019

    Article  CAS  Google Scholar 

  • Horwitz EM, Le Blanc K, Dominici M et al (2005) Clarification of the nomenclature for MSC: the international society for cellular therapy position statement. Cytotherapy 7:393–395

    Article  PubMed  CAS  Google Scholar 

  • Le Blanc K, Ringden O (2007) Immunomodulation by mesenchymal stem cells and clinical experience. J Intern Med 262:509–525

    Article  PubMed  Google Scholar 

  • Lendeckel S, Jodicke A, Christophis P et al (2004) Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report. J Craniomaxillofac Surg 32:370–373

    Article  PubMed  Google Scholar 

  • Leobon B, Roncalli J, Joffre C et al (2009) Adipose-derived cardiomyogenic cells: in vitro expansion and functional improvement in a mouse model of myocardial infarction. Cardiovasc Res 83:757–767

    Article  PubMed  CAS  Google Scholar 

  • Maumus M, Peyrafitte J, D’Angelo R et al (2010) Native human adipose stromal cells: Localization, morphology and phenotype. Int J Obes (in press)

    Google Scholar 

  • Mazo M, Planat-Benard V, Abizanda G et al (2008) Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction. Eur J Heart Fail 10:454–462

    Article  PubMed  Google Scholar 

  • Menasche P (2009) Cell-based therapy for heart disease: a clinically oriented perspective. Mol Ther 17:758–766

    Article  PubMed  CAS  Google Scholar 

  • Mesimaki K, Lindroos B, Tornwall J et al (2009) Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. Int J Oral Maxillofac Surg 38:201–209

    Article  PubMed  CAS  Google Scholar 

  • Miranville A, Heeschen C, Sengenes C et al (2004) Improvement of postnatal neovascularization by human adipose tissue-derived stem cells. Circulation 110:349–355

    Article  PubMed  CAS  Google Scholar 

  • Mojallal A, Foyatier JL (2004) Historical review of the use of adipose tissue transfer in plastic and reconstructive surgery. Ann Chir Plast Esthet 49:419–425

    Article  PubMed  CAS  Google Scholar 

  • Mojallal A, Lequeux C, Shipkov C et al (2009) Improvement of skin quality after fat grafting: clinical observation and an animal study. Plast Reconstr Surg 124:765–774

    Article  PubMed  CAS  Google Scholar 

  • Noel D, Caton D, Roche S et al (2008) Cell specific differences between human adipose-derived and mesenchymal-stromal cells despite similar differentiation potentials. Exp Cell Res 314:1575–1584

    Article  PubMed  CAS  Google Scholar 

  • Phinney DG, Prockop DJ (2007) Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair—current views. Stem Cells 25:2896–2902

    Article  PubMed  Google Scholar 

  • Pittenger MF, Mackay AM, Beck SC et al (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143–147

    Article  PubMed  CAS  Google Scholar 

  • Planat-Benard V, Silvestre JS, Cousin B et al (2004a) Plasticity of human adipose lineage cells toward endothelial cells: physiological and therapeutic perspectives. Circulation 109:656–663

    Article  PubMed  Google Scholar 

  • Planat-Benard V, Menard C, Andre M et al (2004b) Spontaneous cardiomyocyte differentiation from adipose tissue stroma cells. Circ Res 94:223–229

    Article  PubMed  CAS  Google Scholar 

  • Poglio S, De Toni-Costes F, Arnaud E et al (2010) Adipose tissue as a dedicated reservoir of functional mast cell progenitors. Stem Cells 28:2065–2072

    Article  PubMed  CAS  Google Scholar 

  • Prunet-Marcassus B, Cousin B, Caton D et al (2006) From heterogeneity to plasticity in adipose tissues: site-specific differences. Exp Cell Res 312:727–736

    Article  PubMed  CAS  Google Scholar 

  • Puissant B, Barreau C, Bourin P et al (2005) Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cells. Br J Haematol 129:118–129

    Article  PubMed  Google Scholar 

  • Roberts DL, Dive C, Renehan AG (2010) Biological mechanisms linking obesity and cancer risk: new perspectives. Annu Rev Med 61:301–316

    Article  PubMed  CAS  Google Scholar 

  • Rodeheffer MS, Birsoy K, Friedman JM (2008) Identification of white adipocyte progenitor cells in vivo. Cell 135:240–249

    Article  PubMed  CAS  Google Scholar 

  • Tang W, Zeve D, Suh JM et al (2008) White fat progenitor cells reside in the adipose vasculature. Science 322:583–586

    Article  PubMed  CAS  Google Scholar 

  • Traktuev DO, Merfeld-Clauss S, Li J et al (2008) A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks. Circ Res 102:77–85

    Article  PubMed  CAS  Google Scholar 

  • Yanez R, Lamana ML, Garcia-Castro J et al (2006) Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease. Stem Cells 24:2582–2591

    Article  PubMed  CAS  Google Scholar 

  • Yoshimura K, Sato K, Aoi N et al (2008) Cell-assisted lipotransfer for cosmetic breast augmentation: Supportive use of adipose-derived stem/stromal cells. Aesthet Plast Surg 32:48–55

    Article  Google Scholar 

  • Zimmerlin L, Donnenberg AD, Rubin JP et al (2011) Regenerative therapy and cancer: in vitro and in vivo studies of the interaction between adipose-derived stem cells and breast cancer cells from clinical isolates. Tissue Eng Part A 17:93–106

    Article  PubMed  CAS  Google Scholar 

  • Zuk PA, Zhu M, Ashjian P et al (2002) Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13:4279–4295

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

Our work receives financing from the following European projects: CASCADE and ADIPOA, the Etablissement Français du Sang Pyrénées-Mediterranée, the Fondation pour la Recherche Médicale (the “Normal and Pathological Cardiovascular Aging” Program) and the CTP project, Transpyreneen Stem Cells Group”. No conflicts of interest.

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Authors and Affiliations

  1. Equipe 1 “Plasticité des tissus adipeux”, UMR UPS/CNRS/EFS 5273, U1031 INSERM, BP 84 225, 31432, Toulouse, France

    Louis Casteilla, Valérie Planat-Benard, Patrick Laharrague, Béatrice Cousin & Anne Lorsignol

  2. Université de Toulouse, UPS; UMR 5241, BP 84 225, 31432, Toulouse, France

    Louis Casteilla, Valérie Planat-Benard, Patrick Laharrague, Béatrice Cousin & Anne Lorsignol

  3. Laboratoire d’Hématologie, CHU Toulouse, TSA 50032, 31 059, Toulouse, France

    Patrick Laharrague

Authors
  1. Louis Casteilla
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  2. Valérie Planat-Benard
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  3. Patrick Laharrague
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  4. Béatrice Cousin
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  5. Anne Lorsignol
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Correspondence to Louis Casteilla .

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  1. Rue de la Chine 4, Paris, 75020, France

    Jean-Philippe Bastard

  2. Hôpital Saint-Antoine, Paris, France

    Bruno Fève

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Casteilla, L., Planat-Benard, V., Laharrague, P., Cousin, B., Lorsignol, A. (2013). Prospects for Using Adipose Tissue in Regenerative Medicine. In: Bastard, JP., Fève, B. (eds) Physiology and Physiopathology of Adipose Tissue. Springer, Paris. https://doi.org/10.1007/978-2-8178-0343-2_4

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  • DOI: https://doi.org/10.1007/978-2-8178-0343-2_4

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  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0342-5

  • Online ISBN: 978-2-8178-0343-2

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