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Le transport du glucose dans l’adipocyte blanc

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Physiologie et physiopathologie du tissu adipeux

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Résumé

Le glucose est transporté à travers la membrane plasmique de l’adipocyte grâce à un transport facilité. Il est transporté en fonction des différences de concentration entre l’extérieur et l’intérieur de la cellule sans besoin d’énergie. Le transport de glucose est stimulé par l’insuline dans l’adipocyte in vivo, en culture primaire, et dans des lignées. On sait depuis 1980, bien avant le clonage des protéines responsables du transport de glucose, que l’effet de l’insuline est la conséquence de la redistribution de l’activité transport de glucose depuis l’intérieur de la cellule vers la membrane plasmique [1, 2]. Ce contrôle est perturbé lors d’un jeûne, de l’obésité et du diabète de type 2. Les adipocytes sont hypersensibles à l’insuline lors de la réalimentation après un jeûne, après une restriction calorique et dans la phase de développement de l’obésité. Le transport de glucose par l’adipocyte est donc contrôlé à court terme et à long terme.

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Authors and Affiliations

  1. Inserm U1065 Centre Méditerranéen de Médecine Moléculaire C3M, Équipe «Pathophysiologie cellulaire et moléculaire du diabète et de l’obésité», Université de Nice Sophia Antipolis, Bâtiment Archimed, 151, route de Saint-Antoine-de-Ginestière, BP2 3194, 06204, Nice Cedex 3, France

    M. Cormont

  2. Département de pathologie et d’immunologie, Université de Genève, France

    V. Kaddai

  3. Faculté de Médecine, Centre Médical Universitaire, 1, rue Michelet-Servet, 1211, Genève 4, France

    V. Kaddai

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  1. M. Cormont
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Correspondence to M. Cormont .

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Cormont, M., Kaddai, V. (2013). Le transport du glucose dans l’adipocyte blanc. In: Physiologie et physiopathologie du tissu adipeux. Springer, Paris. https://doi.org/10.1007/978-2-8178-0332-6_7

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  • DOI: https://doi.org/10.1007/978-2-8178-0332-6_7

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0331-9

  • Online ISBN: 978-2-8178-0332-6

  • eBook Packages: MedicineMedicine (R0)

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