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L’angiogenèse dans le tissu adipeux

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Book cover Physiologie et physiopathologie du tissu adipeux

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Résumé

Le rôle majeur du tissu adipeux (TA) est la mise en réserve de lipides. En plus de cette fonction clé dans le maintien de l’homéostasie énergétique de l’organisme, le TA est maintenant reconnu comme un organe endocrine. Ces deux fonctions métaboliques et sécrétoires nécessitent des interactions constantes entre le compartiment sanguin et les adipocytes et mettent ainsi en lumière l’importance du réseau vasculaire du TA. Dans l’espèce humaine, la masse adipeuse présente une capacité unique de développement et de croissance pendant toutes les phases de la vie. L’adipocyte change sa taille de façon dynamique en fonction des quantités de lipides à mettre en réserve ou à mobiliser. Lorsque l’hypertrophie adipocytaire a atteint son état maximal, des nouveaux adipocytes apparaissent provenant de la différenciation (ou adipogenèse) des cellules progénitrices des adipocytes [1]. Même si le nombre d’adipocytes est considéré comme constant chez l’adulte, l’adipogenèse est un processus essentiel pour le renouvellement adipocytaire et le maintien du TA [2]. Cette plasticité du TA nécessite un remodelage constant de son rèseau vasculaire.

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Authors and Affiliations

  1. INSERM 1048, Team 1, I2MC, Bâtiment L4, CHU Rangueil, 1, avenue Jean-Poulhès, BP 84225, 31432, Toulouse Cedex 4, France

    A. Bouloumié & J. Galitzky

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  1. A. Bouloumié
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  2. J. Galitzky
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Correspondence to A. Bouloumié .

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Bouloumié, A., Galitzky, J. (2013). L’angiogenèse dans le tissu adipeux. In: Physiologie et physiopathologie du tissu adipeux. Springer, Paris. https://doi.org/10.1007/978-2-8178-0332-6_3

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  • DOI: https://doi.org/10.1007/978-2-8178-0332-6_3

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0331-9

  • Online ISBN: 978-2-8178-0332-6

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