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Impact des cytokines pro-inflammatoires sur la signalisation insulinique de l’adipocyte

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Physiologie et physiopathologie du tissu adipeux

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Résumé

Au cours de l’obésité, l’inflammation métabolique qui se développe dans le tissu adipeux (TA) va conduire à la production de cytokines inflammatoires (Chapitre Inflammation du tissu adipeux au cours de l’obésité), qui vont activer différentes voies de signalisation qui interfèrent avec la signalisation et les effets métaboliques de l’insuline au sein des adipocytes. Cette résistance à l’action de l’insuline va contribuer aux dysfonctions du TA et au développement de l’insulinorésistance systémique observée lors de l’obésité et du diabète de type 2. Dans ce chapitre, nous décrirons les principaux mécanismes moléculaires utilisés par les cytokines inflammatoires pour diminuer la signalisation insulinique. Nous discuterons également comment le blocage de ces mécanismes peut améliorer la sensibilité à l’insuline.

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Authors and Affiliations

  1. Inserm U1065, Centre méditerranéen de médecine moléculaire, Université de Nice Sophia Antipolis, 151, route de Saint-Antoine-de-Ginestière, BP 23194, 06204, Nice Cedex 3, France

    J.-F. Tanti & Y. Le Marchand-Brustel

  2. School of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania, 735 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA, 19104, USA

    J. Jager

Authors
  1. J.-F. Tanti
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  2. J. Jager
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  3. Y. Le Marchand-Brustel
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Correspondence to J.-F. Tanti .

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Tanti, JF., Jager, J., Marchand-Brustel, Y.L. (2013). Impact des cytokines pro-inflammatoires sur la signalisation insulinique de l’adipocyte. In: Physiologie et physiopathologie du tissu adipeux. Springer, Paris. https://doi.org/10.1007/978-2-8178-0332-6_21

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  • DOI: https://doi.org/10.1007/978-2-8178-0332-6_21

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0331-9

  • Online ISBN: 978-2-8178-0332-6

  • eBook Packages: MedicineMedicine (R0)

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